Haptoglobin 2‐2 Phenotype Is Associated With Increased Acute Kidney Injury After Elective Cardiac Surgery in Patients With Diabetes Mellitus

Feng, Chenzhuo; Naik, Bhiken I.; Xin, Wenjun; Jennie, Z.; Scalzo, David C.; Thammishetti, Swapna; Thiele, Robert H.; Zuo, Zhiyi; Raphael, Jacob

doi:10.1161/jaha.117.006565

Cited by 11 publications

(14 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis of AKI is based on two functional markers, an increase of serum creatinine and a reduction of urinary excretion. Predictors of perioperative AKI in patients undergoing heart surgery include preoperative creatinine level, endstage renal disease, 2-2 phenotype of haptoglobin, advanced age, diabetes mellitus, congestive heart failure, generalized atherosclerosis, cardiovascular collapse, nitric oxide, cyanotic heart disease, duration of surgery and elevated postoperative lactate level [4][5][6][7][8][9]. In patients with severe AKI, oliguria and fluid accumulation, renal replacement therapy is the basic method of treatment [10].…”

Section: Introductionmentioning

confidence: 99%

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

et al. 2020

View full text Add to dashboard Cite

Background: Acute kidney injury (AKI) is one of the serious postoperative complications in patients undergoing heart valve surgery. The aim of the present study was to identify selected biomarkers to predict AKI requiring renal replacement. Methods: A prospective study was conducted on a group of 751 patients undergoing heart valve surgery. The data on risk factors, preoperative complete blood count, course of operations and postoperative period was assessed. The primary endpoint at the 30-day follow-up was postoperative AKI requiring renal replacement therapy. The secondary end-point was death from all causes in patients with postoperative AKI requiring renal replacement. Results: The primary endpoint occurred in 46 patients. At multivariate analysis: age, red cell distribution width (RDW) and C-reactive protein remained independent predictors of the primary endpoint. Hemoglobin and RDW were associated with an increased risk of death. Conclusions: Elevated RDW is associated with a higher risk of postoperative AKI and death in patients with AKI. (Cardiol J XXXX; XX, X: xx-xx)

show abstract

Section: Introductionmentioning

confidence: 99%

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hamdy et al, [41] reported that haptoglobin phenotype as a risk factor for coronary artery diseases and cardiovascular diseases in type 2 diabetes. Also, Feng et al, [42] reported that haptoglobin 2-2 phenotype is associated with increase acute kidney injury in patients with diabetes mellitus. This study is in accordance with the work of Olaniyan et al, [43] that reported higher level of haptoglobin in Nigeria type 2 diabetes due there was a high frequency of Hp 2-2 allele gene genotype which led to vascular complications.…”

Section: Discussionmentioning

confidence: 99%

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

C¹,

U²,

C³

2019

SJBR

View full text Add to dashboard Cite

Type 2 diabetes mellitus is a chronic metabolic disorder which has emerged as a health challenge globally due to its insidious on set, late recognition and complications. The present study was aimed at evaluation of acute phase inflammatory proteins in Owerri. Cross Sectional Studies was conducted at Federal Medical Center and Imo State specialist Hospital, Owerri. A total of three hundred subjects which include each one hundred and fifty type 2 diabetics and apparently control subjects between the ages forty and sixty nine years were recruited. Ten millimeters of venous blood was aseptically collected from the subjects. Spectrophotometric, nephlometric, enzyme immunoassay were used for determination of these parameters. The data was analyzed using statistical package for social science 20.0. Test with a probability value of P<0.05 was considered statistically significant. Result from acute phase inflammatory proteins showed that the mean value of c-reactive protein alpha 1-acid glycoprotein, alpha1-antitrypsin, haptoglobin and ceruloplasmin in type 2 diabetics (5.21± 0.91mg/l, 99.34±17.84mg/dl, 152.32 ± 26.69, 154.03±7.75mg/dl, 47.83 ± 6.20mg/dl) were higher which was statistically significant (P=0.001) when compared with the control subjects (3.14± 0.80mg/l,76.86 ± 12.41mg/dl, 114.94±16.11mg/dl, 132.80 ± 79mg/dl, 34.47 ± 3.75mg/dl). There was statistically significant progressive decrease (P=0.04) in c-reactive protein (5.50 ± 0.98, 5.08 ± 0.84, 5.0 4± 0.83mg/l );significant increase (P =0.001) in haptoglobin (149.40 ± 7.78, 155.96 ± 7.93, 157.84 ± 6.12mg/dl) and ceruloplasmin (45.54 ± 6.84, 46.92 ± 5.79, 51.44 ± 6.12mg/dl).The mean value alpha1-acid glycoprotein in female type 2 diabetics was statistically significantly higher (P=0.001) when compared to male (10.912± 17.29 v 89.55± 0.19mg/dl) .

show abstract

“…The main strength of the current work is its transethnic design with inclusion (33,34). Unfortunately, data on these two variables were not available in both cohorts.…”

Section: Discussionmentioning

confidence: 99%

Association of Urine Haptoglobin With Risk of All-Cause and Cause-Specific Mortality in Individuals With Type 2 Diabetes: A Transethnic Collaborative Work

Liu

Saulnier

et al. 2020

Diabetes Care

View full text Add to dashboard Cite

Haptoglobin is an acute-phase reactant with pleiotropic functions. We aimed to study whether urine haptoglobin may predict risk of mortality in people with type 2 diabetes. RESEARCH DESIGN AND METHODSWe employed a transethnic approach with a cohort of Asian origin (Singapore) (N 5 2,061) and a cohort of European origin (France) (N 5 1,438) included in the study. We used survival analyses to study the association of urine haptoglobin with risk of all-cause and cause-specific mortality. RESULTSA total of 365 and 525 deaths were registered in the Singapore cohort (median follow-up 7.5 years [interquartile range 3.5-12.8]) and French SURDIAGENE cohort (median follow-up 6.8 years [interquartile range 4.3-10.5], respectively. Singapore participants with urine haptoglobin in quartiles 2 to 4 had higher risk for all-cause mortality compared with quartile 1 (unadjusted hazard ratio [HR] 1.47 [95% CI 1.02-2.11], 2.28 [1.62-3.21], and 4.64 [3.39-6.35], respectively). The association remained significant in quartile 4 after multiple adjustments (1.68 [1.15-2.45]). Similarly, participants in the French cohort with haptoglobin in quartile 4 had significantly higher hazards for all-cause mortality compared with quartile 1 (unadjusted HR 2.67 [2.09-3.42] and adjusted HR 1. 49 [1.14-1.96]). In both cohorts, participants in quartile 4 had a higher risk of mortality attributable to cardiovascular disease and infection but not malignant tumor. CONCLUSIONSUrine haptoglobin predicts risk of mortality independent of traditional risk factors, suggesting that it may potentially be a novel biomarker for risk of mortality in patients with type 2 diabetes.Patients with type 2 diabetes have a higher standardized mortality ratio compared with people without diabetes (1,2). Although cardiovascular disease (CVD) is the leading cause of premature death in this population, the presence of type 2 diabetes is also associated with increased risk of mortality attributable to noncardiovascular causes such as infectious disease, cancer, and renal disease (3).

show abstract

Haptoglobin 2‐2 Phenotype Is Associated With Increased Acute Kidney Injury After Elective Cardiac Surgery in Patients With Diabetes Mellitus

Cited by 11 publications

References 63 publications

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

Association of Urine Haptoglobin With Risk of All-Cause and Cause-Specific Mortality in Individuals With Type 2 Diabetes: A Transethnic Collaborative Work

Contact Info

Product

Resources

About