Haptoglobin 1F Allele Frequency Is High among Indigenous Populations in the State of Durango, Mexico

Delanghe, Joris; Langlois, Michel; Esquivel, Cosme Alvarado; Haene, H. De; Buyzere, M. De

doi:10.1159/000022927

Cited by 5 publications

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“…The frequency of the Hp *1F allele was highest in the Afro-descendant Kalunga (29.3%) and lowest in the indigenous population of Kayabi (2.6%). This finding agrees with reports in which a higher Hp *1 frequency has been linked to a higher Hp *1F frequency (Delanghe et al , 2000; Carter and Worwood, 2007). In addition, the Hp frequency distribution in the populations studied was not homogenous (p < 0.0001 in the heterogeneity test) and probably reflected selection or recent ethnic admixture.…”

Section: Discussionsupporting

confidence: 93%

“…This variation was attributable essentially to the Hp *1F allele since variation in the Hp *1S allele frequency was very low among these populations (no marked geographical differences). Similar variation in the Hp *1 allele has been reported for Central American populations (Delanghe et al , 2000), although the ratios were different from those seen here.…”

Section: Discussionsupporting

confidence: 68%

“…There is also a significant difference in the frequency distribution of Hp *1F and Hp *1S alleles among populations worldwide (Carter and Worwood, 2007). An extreme case of populational variation was reported for the Hp *1F allele in which a geographical cline of this allele increased in the same direction as the Hp *1 allele, whereas the Hp *1S frequency showed no variation (Delanghe et al , 2000). …”

Section: Introductionmentioning

confidence: 99%

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Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

et al. 2009

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Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp *2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequencies vary according to the ethnic origin of the population. The Hp*1 allele has two subtypes, Hp *1F and Hp *1S , that also vary in their frequencies among populations worldwide. In this work, we examined the distribution frequencies of haptoglobin subtypes in three Brazilian population groups of different ethnicities. The haptoglobin genotypes of Kayabi Amerindians (n = 56), Kalunga Afro-descendants (n = 70) and an urban population (n = 132) were determined by allele-specific PCR. The Hp*1F allele frequency was highest in Kalunga (29.3%) and lowest in Kayabi (2.6%). The Hp*1F/Hp*1S allele frequency ratios were 0.6, 1.0 and 0.26 for the Kayabi, Kalunga and urban populations, respectively. This variation was attributable largely to the Hp*1F allele. However, despite the large variation in Hp*1F frequencies, results of F ST (0.0291) indicated slight genetic differentiation among subpopulations of the general Brazilian population studied here. This is the first Brazilian report of variations in the Hp*1F and Hp*1S frequencies among non-Amerindian Brazilians.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

et al. 2009

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“…Frequency of the HP 2 allele in our study was higher (66.4%) as compared with frequency previously reported in indigenous populations from Durango State (37.9%) [23], findings that could be explained in part because our study was focused on Mexican mestizos, from urban area of Durango city.…”

Section: Discussioncontrasting

confidence: 71%

Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

et al. 2014

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Objective. To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects. Materials and Methods. A cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to the HP genotype into the HP 1/HP 1, HP 2/HP 1, and HP 2/HP 2 groups. Distribution of HP genotypes was 49, 87, and 140 for the HP 1/HP 1, HP 2/HP 1, and HP 2/HP 2, respectively. The HP genotype was determined using the polymerase chain reaction method. A multiple linear regression analysis adjusted by age, sex, waist circumference, and total body fat was used to determine the association between HP genotypes with TNF-α, IL-6, and high-sensitivity C-reactive protein (hsCRP) levels. Results. A multiple linear regression analysis adjusted by sex, waist circumference, and total body fat was performed showing a significant association between the HP 2/HP 2 genotype and TNF-α (β = 0.180; 95% CI 14.41–159.64, P = 0.01) and IL-6 (β = 0.188; 95% CI 1.53–12.72, P = 0.01) levels, but not with hsCRP (β = −0.008; 95% CI −1.64–1.47, P = 0.914) levels, whereas the HP 2/HP 1 genotype showed no association compared with the HP 1/HP 1 genotype (control group). Conclusion. Results of our study show that the HP 2/HP 2 genotype is associated with elevated TNF-α and IL-6, but not with hsCRP, levels in obese subjects.

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“…From the migrations point of view, and the supposed oriental origin of the America's population, it is interesting to notice that meanwhile Asians exhibit high frequency of the CYP2E1*c2, ADH1B*2, and ALDH2*2 polymorphic alleles, CYP2E1*c2 frequency was high in HUI but ADH1B*2 and ALDH2*2 alleles were practically absent (Delanghe et al, 2000;Horai et al, 1993). However, to have a better understanding and to correctly interpret the meaning of these findings, migration and historical analysis should be conducted.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of Alcohol Metabolizing Enzymes in Indigenous Mexican Population: Unusual High Frequency of CYP2E1c2* Allele

Gordillo-Bastidas

Panduro

Gordillo-Bastidas

et al. 2009

Alcoholism Clin & Exp Res

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Background: Alcohol abuse represents the major identified etiological factor of cirrhosis in Me´xico. ADH1B, ALDH2, and CYP2E1 have been considered candidate genes in alcohol-related diseases. Controversial results probably due to ethnic differences, among other factors, have been reported. Mexican Mestizos (MES) derive from the combination of indigenous, Spaniard, and African genes. Huichols (HUI) constitute an indigenous group from western Mexico with no racial admixture. We determined ADH1B*2, ALDH2*2, and CYP2E1*c2 allele frequencies in healthy HUI and MES from western Mexico. Lipid and hepatic profile were also carried out.Methods: One hundred and one HUI and 331 MES subjects were studied. Genotype and allele frequency were assessed through polymerase chain reaction-restriction fragment length polymorphism after DNA isolation from peripheral leukocytes. Commercial kits for lipid and hepatic determinations were used.Results: Polymorphic allele distribution in HUI was: 0% ADH1B*2, 0.5% ALDH2*2, 51.5% CYP2E1*c2; in MES: 3.4% ADH1B*2, 0% ALDH2*2, 16.1% CYP2E1*c2. Frequency of ADH1B*2 was statistically (p < 0.001) lower in HUI than MES. CYP2E1*c2 polymorphic allele was significantly higher (p < 0.0001) in HUI than MES. Hepatic profile was normal in both groups. HUI showed a better lipid profile than MES independently of genotype.Conclusions: Huichols exhibited the highest CYP2E1*c2 allele frequency of the world documented up to this date; meanwhile, ADH1B*2 and ALDH2*2 were practically absent. This feature could be useful in the understanding of Mexican population gene composition, alcohol metabolism, and alcoholic liver disease development. However, further association studies are necessary. The heterogeneity of Mexican population was evidenced by the significantly different distribution of CYP2E1*c2 allele observed among different regions of the country. Lipid and hepatic values were not associated to genotype. This report constitutes the first study dealing with gene polymorphisms of alcohol metabolizing enzymes conducted in HUI.

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Haptoglobin 1F Allele Frequency Is High among Indigenous Populations in the State of Durango, Mexico

Cited by 5 publications

References 8 publications

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

Polymorphisms of Alcohol Metabolizing Enzymes in Indigenous Mexican Population: Unusual High Frequency of CYP2E1c2* Allele

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Haptoglobin 1F Allele Frequency Is High among Indigenous Populations in the State of Durango, Mexico

Cited by 5 publications

References 8 publications

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities

Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

Polymorphisms of Alcohol Metabolizing Enzymes in Indigenous Mexican Population: Unusual High Frequency of CYP2E1*c2 Allele

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Polymorphisms of Alcohol Metabolizing Enzymes in Indigenous Mexican Population: Unusual High Frequency of CYP2E1c2* Allele