2007
DOI: 10.1373/clinchem.2006.078808
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Haptocorrin (Transcobalamin I) and Cobalamin Deficiencies

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Cited by 4 publications
(2 citation statements)
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“…TC I and cobalamin levels correlate strongly in normal plasma (Carmel et al , 2001; Morkbak et al , 2006) because the same holo‐TC I accounts for >70% of both those levels (Carmel, 2007). In severe TC I deficiency, however, plasma cobalamin is attached only to TC II (holo‐TC II) and some minor, unidentified binding proteins mentioned earlier.…”
Section: Discussionmentioning
confidence: 99%
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“…TC I and cobalamin levels correlate strongly in normal plasma (Carmel et al , 2001; Morkbak et al , 2006) because the same holo‐TC I accounts for >70% of both those levels (Carmel, 2007). In severe TC I deficiency, however, plasma cobalamin is attached only to TC II (holo‐TC II) and some minor, unidentified binding proteins mentioned earlier.…”
Section: Discussionmentioning
confidence: 99%
“…It has been associated with severely impaired granulopoiesis (Carmel et al , 1975; Carmel, 1981, 1983b). However, proposed acquired TC I deficiency in patients with acquired immunodeficiency syndrome (AIDS) and pregnant women with often low cobalamin levels appears to be limited to holo‐TC I reduction (Hansen et al , 1992; Koebnick et al , 2002), and a proposal that cobalamin deficiency itself reduces total TC I (Morkbak et al , 2006) has raised methodological concerns (Carmel, 2007).…”
Section: Discussionmentioning
confidence: 99%