Hapten-specific T-Cell Unresponsiveness Induced by Benzylpenicilloyl Autologous Gamma Globulin Conjugates in Human Lymphocytes In Vitro

Oligonucleotide linked to human gammaglobulin specifically diminishes anti-DNA antibody formation in cultured lymphoid cells from patients with systemic lupus erythematosus.

“…In murine models other investigators have also shown that nucleoside linked to dGL or DNA fragments linked to poly-d-lysine together with cyclophosphamide can suppress anti-DNA antibodies resulting in clinical improvement of murine lupus (36,37). In this study, we have not examined the mechanism of tolerance in vitro, but in other human models involving haptens linked to HGG we have shown that not only B cells but also T cells are involved (38,39). Clearly the tolerogenicity of the conjugate is determined by the carrier molecule HGG.…”