Happiness and Inflammatory Responses to Acute Stress in People With Type 2 Diabetes

Panagi, Laura; Poole, Lydia; Hackett, Ruth A.; Steptoe, Andrew

doi:10.1093/abm/kay039

Cited by 31 publications

(25 citation statements)

References 61 publications

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“…The results of this study showed that the happiness of patients with higher education level (“high school or secondary school,” “college,” and “undergraduate and above”) was better than those with lower education level, which was in accordance with the results of Pintaudi et al [ 24 ] and Panagi et al [ 25 ] The former is better than the latter in integrating various information channels and acquiring disease management related knowledge. It is easy to have a higher sense of responsibility in the process of disease management and is handier in dealing with the changes of diabetes and complications.…”

Section: Discussionsupporting

confidence: 91%

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

et al. 2020

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This study aimed to investigate diabetes distress, happiness, and its associated factors of patients with type 2 diabetes mellitus (T2DM) treated by different therapies, and to analyze the related impact factors. A total of 1512 patients with T2DM were randomly selected from 18 tertiary hospitals in Hunan province from January 2016 to April 2016 who has been treated with oral antidiabetics monotherapy, insulin monotherapy, and combination therapy. Use the general information questionnaire, WHO-5 (the World Health Organization 5 well-being index) and PAID (the problem areas in diabetes scale) to collect the data. There are 846 (55.95%) patients that have serious emotional disorders, and the diabetes related distress in insulin treatment group was higher than that in combination treatment group ( P < .05). Happiness of T2DM patients in combination therapy was higher than oral antidiabetic drug monotherapy and insulin monotherapy ( P < .05). There was a negative correlation between diabetic suffering and happiness in patients with different treatments ( R ranged from –0.335 to –0.436, P < .001). Age and happiness experience could explain 14.8% of the variance. Acute and chronic complications, controlled blood glucose level, lifestyle, therapies, and school education can explain 18.3% variance. Under different therapies, the suffering and happiness of T2DM patients differed from each other. The suffering and happiness of T2DM were related to different therapies, age, complications, glycaemic control, lifestyle, school education, and so on.

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Section: Discussionsupporting

confidence: 91%

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

et al. 2020

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“…Of these, 101 participants had complete information for all IL-6 and IL-1RA measurements, and 102 individuals had full MCP-1 data. The missing data were due to issues in blood sampling as previously reported (Panagi, Poole, Hackett, & Steptoe, 2018). Issues included difficulties maintaining a functioning cannula in obese participants and cannula failure part way through the session.…”

Section: Participant Characteristicsmentioning

confidence: 93%

Loneliness and biological responses to acute stress in people with Type 2 diabetes

et al. 2019

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Loneliness is linked with all‐cause mortality and coronary heart disease. Altered neuroendocrine and inflammatory responses to stress constitute potential pathways linking loneliness and ill‐health. Stress responsivity is modified in people with Type 2 diabetes, but it is unclear whether loneliness influences biological stress responses in this population. We assessed interleukin‐6 (IL‐6), interleukin‐1 receptor antagonist (IL‐1RA), monocyte chemoattractant protein‐1 (MCP‐1), and cortisol responses to acute stress in 135 people with Type 2 diabetes. Loneliness was measured used the Revised UCLA Loneliness Scale. Loneliness was inversely associated with cortisol output poststress ( B = −4.429, p = 0.019) independent of age, sex, education, marital status, body mass index, and smoking. Lonelier individuals had raised MCP‐1 concentrations 75 min poststress independent of covariates ( B = 0.713, p = 0.022). No associations between loneliness and IL‐6 or IL‐1RA concentrations were detected. These results suggest that loneliness is associated with disturbances in stress responsivity in people with diabetes, and the impact of loneliness on health in people with diabetes may be mediated in part through dysregulation of inflammatory and neuroendocrine systems. Future research is required to understand if such changes increase the risk of poorer outcomes in this population.

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“…As an example of the potential confluence of stress, food access, and racism affecting health behavior that influences chronic disease, non-Hispanic Black women with diabetes reported that experienced racism led to maladaptive coping strategies which included unhealthy food choices and that these choices affected diabetes self-management ( 91 , 110 ). Lastly, interventions should certainly incorporate the element of hope, as hope, optimism, and happiness are essential components to human health and have been shown to be accompanied by decreasing IL-6 levels ( 111 , 112 ). This might seem like a list of unbreakable, vicious cycles pre-dispositioning vulnerable populations to COVID-19.…”

Section: Behavioral Interventions Impacting Il-6 Levels and The Immunmentioning

confidence: 99%

Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide

Baumer

Farmer

Premeaux

et al. 2020

Front. Public Health

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It is evident that health disparities exist during the COVID-19 pandemic, a pandemic caused by the novel coronavirus SARS-CoV-2. Underlying reasons for COVID-19 health disparities are multi-factorial. However, social determinants, including those regarding socioeconomic status, social inequalities, health behaviors, and stress, may have implications on these disparities. Exposure to one or more of these social determinants is associated with heightened inflammatory responses, particularly increases in the cytokine interleukin-6 (IL-6), as well as immune system dysfunction. Thus, an amplified effect during COVID-19 could occur, potentially resulting in vulnerable patients experiencing an intensified cytokine storm due to a hyperactive and dysfunctional immune response. Further understanding how social determinants play a mechanistic role in COVID-19 disparities could potentially help reduce health disparities overall and in future pandemics.

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Happiness and Inflammatory Responses to Acute Stress in People With Type 2 Diabetes

Abstract: Happier individuals with T2D have lower inflammatory markers before and after acute stress, albeit independent of stress responsivity. Findings could provide a protective physiological pathway linking daily happiness with better health in people with T2D.

Cited by 31 publications

References 61 publications

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

Loneliness and biological responses to acute stress in people with Type 2 diabetes

Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide

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