Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia

Yoshida, Masakuni; Shiroiwa, Kyoichi; Mouri, Kentaro; Ishiguro, Hiroki; Supriyanto, Irwan; Ratta‐apha, Woraphat; Eguchi, Noriomi; Okazaki, Kenji; Sasada, Toru; Fukutake, Masaaki; Hashimoto, Takeshi; Inada, Toshiya; Arinami, Tadao; Sato, Osamu; Hishimoto, Akitoyo

doi:10.1016/j.schres.2012.06.031

Cited by 29 publications

(23 citation statements)

References 45 publications

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“…In addition, IL-1β and IL-1RA gene polymorphisms appear tied to cognitive ability in Caucasians and African-Americans [84]. Likewise, susceptibility to schizophrenia is coupled to perturbations within IL-1 gene family components [85]. Serum IL-1β levels are correlated with anxiety and mood disorders in those with rheumatoid arthritis [86].…”

Section: Discussionmentioning

confidence: 99%

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

et al. 2017

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Background Inflammation within the central nervous system (CNS) is frequently comorbid with anxiety. Importantly, the pro-inflammatory cytokine most commonly associated with anxiety is IL-1β. The bioavailability and activity of IL-1β is regulated by caspase-1-dependent proteolysis vis-a-vis the inflammasome. Thus, interventions regulating the activation or activity of caspase-1 should reduce anxiety especially in states that foster IL-1β maturation. Methods Male C57BL/6j, C57BL/6j mice treated with the capase-1 inhibitor biotin-YVAD-cmk, caspase-1 knockout (KO) mice and IL-1R1 KO mice were fasted for 24 hours or allowed ad libitum access to food. Immediately after fasting, caspase-1 activity was measured in brain region homogenates while activated caspase-1 was localized in the brain by immunohistochemistry. Mouse anxiety-like behavior and cognition were tested using the elevated zero maze and novel object/object location tasks, respectively. Results A 24 h fast in mice reduced the activity of caspase-1 in whole brain and in the prefrontal cortex, amygdala, hippocampus, and hypothalamus by 35%, 25%, 40%, 40%, and 40% respectively. A 24 h fast also reduced anxiety-like behavior by 40% and increased novel object and object location recognition by 21% and 31%, respectively. IL-1β protein, however, was not reduced in the brain by fasting. ICV administration of YVAD decreased caspase-1 activity in the prefrontal cortex and amygdala by 55%, respectively leading to a 64% reduction in anxiety like behavior. Importantly, when caspase-1 KO or IL1-R1 KO mice are fasted, no fasting-dependent reduction in anxiety-like behavior was observed. Conclusions Results indicate that fasting decrease anxiety-like behavior and improves memory by a mechanism tied to reducing caspase-1 activity throughout the brain.

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Section: Discussionmentioning

confidence: 99%

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

et al. 2017

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“…As TaqMan probes for rs2853550 and rs3917356 were not available, these two SNVs were excluded from our analysis. To confirm the association of haplotypes with schizophrenia (Yoshida et al ., ), we also included four SNVs (rs1143623, rs4848306, rs4369864 and rs6745746) within the IL1B promoter region. In addition, we included a promoter SNV (rs1143627), which is known to affect transcription (Chen et al ., ).…”

Section: Methodsmentioning

confidence: 99%

“…Genetic variations in IL1B have previously been tested for association with schizophrenia, with conflicting results (Tatsumi et al ., ; Chowdari et al ., ; Meisenzahl et al ., ; Zanardini et al ., ; Papiol et al ., ; Rosa et al ., ; Shirts et al ., ; Hänninen et al ., ; Betcheva et al ., ; Sasayama et al ., ; Borkowska et al ., ; Fatjó‐Vilas et al ., ; Yoshida et al ., ). However, almost all of these earlier studies were performed using relatively small sample sizes and a limited number of markers.…”

Section: Introductionmentioning

confidence: 97%

“…() examined five tagging IL1B SNVs, and found an association between rs1143633 and schizophrenia in a Japanese population, particularly in women. Another Japanese study reported associations between schizophrenia and haplotypes comprising five tagging SNVs within the expression quantitative trait locus of the IL1B promoter region (Yoshida et al ., ). However, the overall inconsistencies in these studies require further investigation using both common and rare SNVs.…”

Section: Introductionmentioning

confidence: 97%

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Interleukin 1 beta gene and risk of schizophrenia: detailed case–control and family‐based studies and an updated meta‐analysis

Shibuya

Watanabe

Nunokawa

et al. 2013

Human Psychopharmacology

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“…The Kobe sample comprised 660 patients with schizophrenia (344 men and 316 women; mean age 52.6 714.9 years) and 734 control individuals (345 men and 389 women; mean age 54.37 18.6 years). Psychiatric assessment of each participant was conducted, as previously described (Watanabe et al, 2006;Yoshida et al, 2012).…”

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confidence: 99%

A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population

Watanabe

Hishimoto

Shibuya

et al. 2014

Psychiatry Research

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Haplotypes in the expression quantitative trait locus of interleukin-1β gene are associated with schizophrenia

Cited by 29 publications

References 45 publications

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition

Interleukin 1 beta gene and risk of schizophrenia: detailed case–control and family‐based studies and an updated meta‐analysis

A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population

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