Haplotype restricted differences in in vitro production of tumor necrosis factor alpha and lymphotoxin alpha in patients with inflammatory bowel disease and healthy controls

Bouma, Gerd; Crusius, J.B.A.; Pool, M. Oudkerk; Kolkman, J. J.; Blomberg, Bme von; Meuwissen, S. G. M.; Peña, A. S.

doi:10.1016/0016-5085(95)27456-1

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A second method of investigating the functionality of the TNF promoter region variants is to compare differences in TNF production between the different alleles/genotypes ex vivo or in vivo . These studies have focused on both healthy populations and populations with specific illnesses, for example diabetes , multiple sclerosis , and sepsis .…”

Section: The Single‐nucleotide Variants (Snvs) In the Promoter Regionmentioning

confidence: 99%

Immunology and genetics of tumour necrosis factor in allergic contact dermatitis

Dittmar

Schuttelaar

2017

Contact Dermatitis

View full text Add to dashboard Cite

SummaryDuring the sensitization phase of allergic contact dermatitis, the proinflammatory cytokine tumour necrosis factor (TNF) plays an important role by promoting epidermal Langerhans cell migration to draining lymph nodes. It also plays a role during the elicitation phase. The TNF gene (TNF) is located within the major histocompatibility complex region. Many single-nucleotide variants exist in the promoter region of TNF, and these may either increase or decrease mRNA transcription and therefore lead to higher or lower levels of TNF. The most extensively studied single-nucleotide variant of TNF is a base pair substitution in the promoter region at location -308 relative to the transcription start site (rs1800629, TNF -308G>A), which is believed to increase transcription and lead to higher TNF levels. The role of TNF in allergic contact dermatitis and the functionality of TNF -308G>A are reviewed in this article. The association between genetic variants and disease can be studied in a case-control design. Only a few case-control studies investigating the association between TNF -308G>A and allergic contact dermatitis have been published, with contradictory results. These are reviewed critically, and suggestions for future case-control studies on this topic are made.Key words: allergic contact dermatitis; genetics; immunology; TNF -308G>A; tumour necrosis factor. Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity reaction caused by exposure of the skin to allergens (1). It starts with a sensitization phase, in which a person gains the potential to develop a cutaneous allergic reaction to a certain allergen, i.e., acquires contact allergy. Repeated exposure to this allergen (or a cross-reacting allergen) in a sensitized person causes inflammation of the skin. This is called the elicitation phase. The level of exposure, determined by dose and time of exposure, is the most important exogenous factor determining whether an individual becomes sensitized. However, a certain amount of interindividual variability

show abstract

Section: The Single‐nucleotide Variants (Snvs) In the Promoter Regionmentioning

confidence: 99%

Immunology and genetics of tumour necrosis factor in allergic contact dermatitis

Dittmar

Schuttelaar

2017

Contact Dermatitis

View full text Add to dashboard Cite

show abstract

Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD)

Bouma

Xia

Crusius

et al. 1996

Clinical and Experimental Immunology

132

View full text Add to dashboard Cite

SUMMARYIn 153 patients with IBD, 64 with Crohn's disease (CD), and 89 with ulcerative colitis (UC), as well as in 54 healthy controls (HC), the frequencies of four known di-allelic polymorphisms in the genes for TNF-a and lymphotoxin alpha (LTa) were investigated. In the Dutch population, the alleles of these four polymorphisms are present in only five combinations, called TNF haplotypes: TNF-C, -E, -H, -I, -P. Furthermore, the relation with the presence of perinuclear anti-neutrophil cytoplasmic autoantibodies (P-ANCA) was studied. A small, but statistically significant, association between the polymorphism at position -308 in the promoter region of the TNF-a gene and UC was found. The frequency of the uncommon TNF-tr -308 allele 2 was found to be decreased in patients with UC compared with HC (allele frequency of allele 2 in UC patients 0.15 versus 0.25 in HC, P = 0.044). No significant differences in distribution of the TNF haplotypes were found between IBD patients and HC, although there was a tendency towards a higher frequency of the TNF-C haplotype in UC patients compared with controls (haplotype frequency 22% versus 13%; P = 0.19). No statistically significant differences in distribution of the TNF haplotypes were observed between P-ANCA-positive and P-ANCA-negative UC patients. The strength of the associations indicates that TNF genes are not markers for the predisposition to suffer from IBD. They may, however, be markers of subsets of patients with UC and CD.

show abstract

Haplotype restricted differences in in vitro production of tumor necrosis factor alpha and lymphotoxin alpha in patients with inflammatory bowel disease and healthy controls

Cited by 2 publications

References 0 publications

Immunology and genetics of tumour necrosis factor in allergic contact dermatitis

Immunology and genetics of tumour necrosis factor in allergic contact dermatitis

Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD)

Contact Info

Product

Resources

About