Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population

Mukhi, Benudhar; Gupta, Himanshu; Wassmer, Samuel C.; Anvikar, Anupkumar R.; Ghosh, Susanta Kumar

doi:10.1007/s11033-020-05934-1

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Evidence indicates that host genetics can regulate Pf infection, specifically in severe, life-threatening manifestations of the disease ( Jallow et al., 2009 ; Gupta et al., 2013 ; Saadi et al., 2013 ; Fernandes et al., 2015 ; Gupta et al., 2015b ; Mukhi et al., 2020 ). During human evolution, there are classical examples of genetic variations that have occurred to provide resistance against malaria, including i) sickle-cell trait; ii) thalassemia; iii) glucose-6-phospahte dehydrogenase (G6PD) deficiency; and iv) Duffy antigen deficiency ( Hedrick, 2011 ).…”

Section: Biomarkersmentioning

confidence: 99%

Diagnosis of cerebral malaria: Tools to reduce Plasmodium falciparum associated mortality

Muppidi

Wright²,

Wassmer³

et al. 2023

Front. Cell. Infect. Microbiol.

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Cerebral malaria (CM) is a major cause of mortality in Plasmodium falciparum (Pf) infection and is associated with the sequestration of parasitised erythrocytes in the microvasculature of the host’s vital organs. Prompt diagnosis and treatment are key to a positive outcome in CM. However, current diagnostic tools remain inadequate to assess the degree of brain dysfunction associated with CM before the window for effective treatment closes. Several host and parasite factor-based biomarkers have been suggested as rapid diagnostic tools with potential for early CM diagnosis, however, no specific biomarker signature has been validated. Here, we provide an updated review on promising CM biomarker candidates and evaluate their applicability as point-of-care tools in malaria-endemic areas.

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