Haplotype‐based association of Vascular Endothelial Growth Factor gene polymorphisms with urothelial bladder cancer risk in Tunisian population

Abstract

CIC haplotype of VEGF gene may be important risk factor for UBC development in Tunisia.

VEGF gene rs3025039C/T and rs833052C/A variants are associated with bladder cancer risk in Asian descendants

“…With no obvious correlation identified in hospital‐based studies for allelic contrast (OR = 0.96; 95% CI = 0.69‐1.34; P = 0.813), homozygote comparison (OR = 1.35; 95% CI = 0.94‐1.92; P = 0.101), dominant genetic model (OR = 0.93; 95% CI = 0.61‐1.41; P = 0.730), and recessive genetic model (OR = 1.37; 95% CI = 0.97‐1.95; P = 0.078). Furthermore, we removed two studies that were inconsistent with HWE and also identified similar results (Table b). Notable association between VEGF gene rs3025039C/T polymorphism and BCa risk were observed in Asian descendants under four genetic models (allelic contrast: raw OR = 1.19; 95% CI = 1.05‐1.34; P = 0.006; homozygote comparison: raw OR = 1.54; 95% CI = 1.12‐2.12; P = 0.008; dominant genetic model: raw OR = 1.18; 95% CI = 1.02‐1.36; P = 0.027; and recessive genetic model: raw OR = 1.47; 95% CI = 1.07‐2.01; P = 0.016).…”

“…37 Previous studies have been carried out to demonstrate the association between VEGF gene polymorphisms and BCa risk, but with inconsistent results. [24][25][26][27] Garcı´a-Closas et al 27 indicated that VEGF gene rs833052 variant was associated with increased risk for BCa (OR = 2.52; 95% CI = 1.06-5.97) based on Spanish population, with no positive correlation observed for rs3025039 polymorphism (OR = 1.63; 95% CI = 0.73-3.61). Fu et al 25 found that both of these two variants were significantly associated with BCa susceptibility in the Chinese population.…”

“…37 Previous studies have been carried out to demonstrate the association between VEGF gene polymorphisms and BCa risk, but with inconsistent results. [24][25][26][27] Garcı´a-Closas et al 27 24 In this study, we summarized all available data from previous case-control studies and conducted a meta analysis to explore the association of VEGF gene rs3025039C/T and rs833052C/A variants with susceptibility to BCa. Therefore, the statistical power was relatively enhanced and the disadvantages induced by deficient statistical genetic studies of multiple traits could be alleviated.…”

“…Expression of VEGF gene in bladder carcinoma has been indicated to be associated with tumor progression . Previous studies have been carried out to demonstrate the association between VEGF gene polymorphisms and BCa risk, but with inconsistent results . Garcı´a‐Closas et al indicated that VEGF gene rs833052 variant was associated with increased risk for BCa (OR = 2.52; 95% CI = 1.06‐5.97) based on Spanish population, with no positive correlation observed for rs3025039 polymorphism (OR = 1.63; 95% CI = 0.73‐3.61).…”

“…Therefore, we summarized all eligible data to enhance statistical power and to acquire conclusive results for VEGF rs3025039C/T and rs833052C/A variants. [24][25][26][27][28] In addition, we utilized in silico tools to demonstrate the relationship of VEGF expression correlated with BCa susceptibility and survival time.…”