Haplotype analysis of TGF-β1 gene in a preeclamptic population of northern Mexico

Aguilar-Durán, Marisela; Salvador-Moysén, Jaime; Galavíz-Hernández, Carlos; Vazquez-Alaniz, Fernando; Sandoval-Carrillo, Ada Agustina; Velázquez-Hernández, Nadia; Salas-Pacheco, José M.

doi:10.1016/j.preghy.2013.07.007

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…In a Northern Mexico population study, the association between PE risk and the TGFB1 SNPs: −800G/A (rs1800468), −509C/T (rs1800469), and +869T/C (rs1800470) and their haplotypes were evaluated. No association between PE development and the SNPs or haplotypes was observed, although the +869TT genotype was suggested as a protective factor against severe PE (Aguilar-Duran et al, 2014).…”

Section: Genetic Studies In Latin-american Populationsmentioning

confidence: 99%

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Michita

Kaminski

2018

Front. Physiol.

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Placental vascularization is a tightly regulated physiological process in which the maternal immune system plays a fundamental role. Vascularization of the maternal-placental interface involves a wide range of mechanisms primarily orchestrated by the fetal extravillous trophoblast and maternal immune cells. In a healthy pregnancy, an immune cross-talk between the mother and fetal cells results in the secretion of immunomodulatory mediators, apoptosis of specific cells, cellular differentiation/proliferation, angiogenesis, and vasculogenesis, altogether favoring a suitable microenvironment for the developing embryo. In the context of vasculopathy underlying common pregnancy disorders, it is believed that inefficient invasion of extravillous trophoblast cells in the endometrium leads to a poor placental blood supply, which, in turn, leads to decreased secretion of angiogenic factors, hypoxia, and inflammation commonly associated with preterm delivery, intrauterine growth restriction, and preeclampsia. In this review, we will focus on studies published by Latin American research groups, providing an extensive review of the role of genetic variants from candidate genes involved in a broad spectrum of biological processes underlying the pathophysiology of preeclampsia. In addition, we will discuss how these studies contribute to fill gaps in the current understanding of preeclampsia. Finally, we discuss some trending topics from important fields associated with pregnancy vascular disorders (e.g., epigenetics, transplantation biology, and non-coding RNAs) and underscore their possible implications in the pathophysiology of preeclampsia. As a result, these efforts are expected to give an overview of the extent of scientific research produced in Latin America and encourage multicentric collaborations by highlighted regional research groups involved in preeclampsia investigation.

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Section: Genetic Studies In Latin-american Populationsmentioning

confidence: 99%

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Michita

Kaminski

2018

Front. Physiol.

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“…It is a major cause of maternal death and is responsible for high rates of fetal morbidity and mortality [1]. PE is characterized by de novo hypertension (two blood pressure measurements ≥140/90 mm Hg) and proteinuria (>300 mg/24 h) that develops after 20 weeks of gestation in a formerly normotensive woman [2].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in DNA Repair Genes (APEX1, XPD, XRCC1 and XRCC3) and Risk of Preeclampsia in a Mexican Mestizo Population

Sandoval-Carrillo

Méndez-Hernández²,

Vazquez-Alaniz³

et al. 2014

IJMS

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Variations in genes involved in DNA repair systems have been proposed as risk factors for the development of preeclampsia (PE). We conducted a case-control study to investigate the association of Human apurinic/apyrimidinic (AP) endonuclease (APEX1) Asp148Glu (rs1130409), Xeroderma Pigmentosum group D (XPD) Lys751Gln (rs13181), X-ray repair cross-complementing group 1 (XRCC) Arg399Gln (rs25487) and X-ray repair cross-complementing group 3 (XRCC3) Thr241Met (rs861539) polymorphisms with PE in a Mexican population. Samples of 202 cases and 350 controls were genotyped using RTPCR. Association analyses based on a χ2 test and binary logistic regression were performed to determine the odds ratio (OR) and a 95% confidence interval (95% CI) for each polymorphism. The allelic frequencies of APEX1 Asp148Glu polymorphism showed statistical significant differences between preeclamptic and normal women (p = 0.036). Although neither of the polymorphisms proved to be a risk factor for the disease, the APEX1 Asp148Glu polymorphism showed a tendency of association (OR: 1.74, 95% CI = 0.96–3.14) and a significant trend (p for trend = 0.048). A subgroup analyses revealed differences in the allelic frequencies of APEX1 Asp148Glu polymorphism between women with mild preeclampsia and severe preeclampsia (p = 0.035). In conclusion, our results reveal no association between XPD Lys751Gln, XRCC Arg399Gln and XRCC3 Thr241Met polymorphisms and the risk of PE in a Mexican mestizo population; however, the results in the APEX1 Asp148Glu polymorphism suggest the need for future studies using a larger sample size.

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“…After the study of Kim et al . (2009) [9] or Aguilar-Duran et al (2013) [12] was omitted, the association between 869 T>C and PE became insignificant, suggesting that those two studies largely affected the combined results (results not shown).…”

Section: Resultsmentioning

confidence: 96%

“…Our literature search identified five eligible studies for the association between TGF-β 1 polymorphisms and PE risk, with a total of 608 cases and 758 controls concerning four genetic variants of TGF-β 1. Kim et al (2009) [9] investigated two variants (869 T>C and 915 G>C); Aguilar-Duran et al (2013) [12] investigated three variants (869 T>C, 800 G>A, and 509 C>T); Stanczuk et al (2007) [13] investigated two variants (869 T>C and 915 G>C); Lima et al . (2009) [15] investigated two variants (869 T>C and 915 G>C); and Feizollahzadeh et al (2012) [10] investigated two variants (800 G>A and 509 C>T).…”

Section: Resultsmentioning

confidence: 99%

Polymorphisms and Plasma Level of Transforming Growth Factor-Beta 1 and Risk for Preeclampsia: A Systematic Review

Shen

Tan

2014

PLoS ONE

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BackgroundTransforming growth factor-beta 1 (TGF-β1) is thought to be involved in the pathogenesis of preeclampsia (PE), but the results are inconsistent among studies. This article aims to compile an overview of the studies about the associations of TGF-β 1 polymorphism and plasma level with PE risk and to provide recommendations for future research.Methods and ResultsThe databases PubMed, Embase and Web of Science were searched up to December 2013. Five studies investigating the associations of four polymorphisms with the risks of PE were involved. A meta-analysis was conducted for the 869T>C polymorphism and PE risk. The results show that genotype TT of 869T>C polymorphism is a protective factor of PE (pooled odds ratio = 0.73, 95% CI: 0.56, 0.95). Eight case-control studies reported the plasma level of TGF-β 1. The substantial heterogeneity among studies may be attributed to the differences in the blood sample processing and the TGF-β 1 analysis kits. The results suggest that plasma TGF-β 1 level in the second trimester was significantly lower in the PE group than in the normal pregnancy group, but was significantly higher in the PE group during the third trimester.ConclusionsThe current results support that the TGF-β 1 869 T>C polymorphism was associated with the risk of PE. However, the number of eligible studies is small and more studies are needed to clarify whether this association can be detected on larger sample sizes and different populations. Owing to the heterogeneity between studies, no conclusion on the association between plasma TGF-β 1 level and PE risk can be drawn from this review. Further studies about the TGF-β 1 levels at different stages of pregnancy and the development of TGF-β 1 assay methodology are required to reveal the role of TGF-β 1 in the pathological development of PE.

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Haplotype analysis of TGF-β1 gene in a preeclamptic population of northern Mexico

Cited by 13 publications

References 29 publications

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Polymorphisms in DNA Repair Genes (APEX1, XPD, XRCC1 and XRCC3) and Risk of Preeclampsia in a Mexican Mestizo Population

Polymorphisms and Plasma Level of Transforming Growth Factor-Beta 1 and Risk for Preeclampsia: A Systematic Review

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