Haplotype Analysis of Prostate Stem Cell Antigen and Association With Prostate Cancer Risk

Joung, Jae Young; Lee, Yeon-Su; Park, Sohee; Yoon, Hye-Kyoung; Lee, Sang Jin; Park, Weon Seo; Seo, Ho Kyung; Chung, Jinsoo; Kim, Soo-kyoung; Hong, Seung-Hyun; Kim, Jeong Seon; Lee, Kang Hyun

doi:10.1016/j.juro.2011.01.083

Cited by 18 publications

(26 citation statements)

References 20 publications

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“…Overall, there were 32 studies investigating the association between PSCA rs2294008 C>T polymorphism and cancer susceptibility, consisting of 30028 cases and 38765 controls [8, 9, 14-35, 39-43], and 14 studies performed on the relation between PSCA rs2976392 G>A polymorphism and overall cancer susceptibility, with 8190 cases and 7176 controls [8, 14-17, 19, 24, 29, 36-39, 43]. The main characteristics of the studies included in this meta-analysis were summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The studied cancer type included gastric cancer [8, 14-17, 20-22, 25, 26, 31, 32, 34, 39, 41-43], bladder cancer [9, 18, 23, 28, 35, 40], prostate cancer [19], esophageal cancer [20, 33], breast cancer [24], colorectal cancer [27], and gallbladder cancer [29, 30]. In term of ethnicity, 21 studies were performed among Asians, 10 studies among Caucasians, and one study among Africans.…”

Section: Resultsmentioning

confidence: 99%

“…For the PSCA rs2976392 G>A polymorphism, the number of cases ranged from 44 to 1525 while varying control sample sizes (from 60 to 1397) were also observed among selected studies. The studied cancer type included gastric cancer [8, 14-17, 36-39, 43], prostate cancer [19], breast cancer [24], and gallbladder cancer [29]. Of them, 13 studies were performed among Asians and one among Caucasians.…”

Section: Resultsmentioning

confidence: 99%

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PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Dai

Hua

et al. 2015

Genes Cancer

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PSCA gene plays an important role in cell adhesion, proliferation and survival.Increasing studies have focused on the association of PSCA gene rs2294008 C>T and rs2976392 G>A with cancer risk. However, the conclusions were inconsistent. Therefore, we performed a meta-analysis to elucidate whether there is a true association, or artifact. We systematically searched eligible studies from MEDLINE, EMBASE and CBM database. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association. The final analysis included 32 studies consisting of 30028 cases and 38765 controls for the rs2294008 C>T polymorphism, and 14 studies with 8190 cases and 7176 controls for the rs2976392 G>A polymorphism. Consequently, the PSCA rs2294008 C>T polymorphism was significantly associated with increased overall cancer risk. Further stratifications indicated the increased risk was more pronounced for gastric (diffused type and non-gastric cardia adenocarcinoma) and bladder cancer. A similar association was observed for the rs2976392 G>A polymorphism. This meta-analysis demonstrated that both of the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms are associated with increased cancer risk, especially for gastric cancer and bladder cancer. Further large-scale studies with different ethnicities and subtypes of gastric cancer are required to confirm the results from this meta-analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Dai

Hua

et al. 2015

Genes Cancer

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“…A total of 21 articles were used to evaluate the relationship between PSCA polymorphisms and cancer risk, 5 of which (16,19,20,33,34) were excluded because studies were on urinary tumors. Four reviews (35)(36)(37)(38) were also excluded.…”

Section: Results Of Literature Search and Selectionmentioning

confidence: 99%

“…PSCA was also found to express abnormally in other types of malignancies, such as cancers of the bladder, pancreas, esophagus, and stomach (15)(16)(17)(18). Many studies have explored the association between variant genotype of PSCA and risk for cancers of the prostate, bladder, and stomach (16,(19)(20)(21). Two loci in PSCA, rs2976392 and rs2294008, were first identified to be remarkably associated with risk of diffuse type GC based on a 2-stage GWAS study conducted by Sakamoto (21).…”

Section: Introductionmentioning

confidence: 99%

Prostate Stem Cell Antigen Polymorphisms and Susceptibility to Gastric Cancer: A Systematic Review and Meta-analysis

Zhang¹,

Li²,

Wang³

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Many studies have reported that prostate stem cell antigen (PSCA) polymorphisms (rs2294008 and/or 2976392) are significantly associated with gastric cancer (GC) risk, although the published results are inconsistent. We conducted a systematic review and meta-analysis for relevant literatures to quantitatively evaluate the relationship between PSCA polymorphisms and GC susceptibility.Methods: Extensive searches were conducted in three databases up to November 1, 2011. ORs and 95% CIs were used to assess the strength of the associations. The data were further stratified by ethnicity, histopathology, subsite, and study design. All of the associations were evaluated with dominant model and recessive model, respectively. Heterogeneity and publication bias were also assessed by Q test, I

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Evaluation of 17 genetic variants in association with leukemia in the north Indian population using MassARRAY Sequenom

Bhat

Verma

et al. 2021

J Biochem & Molecular Tox

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Leukemia is a heterogeneous disorder, characterized by elevated proliferation of white blood cells. In this study, we explored the association of 17 genetic variants with leukemia patients in the Jammu and Kashmir region of north India. The variants were genotyped by using a high-throughput Agena MassARRAY platform in 758 individuals (166 cases and 592 controls). Of the 17 single-nucleotide polymorphisms (SNPs) studied, five SNPs were showing significant association with the high risk of leukemia in the north Indian population, which includes rs10069690 of telomere reverse transcriptase (TERT) with OR = 0.34 (95% CI,

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Haplotype Analysis of Prostate Stem Cell Antigen and Association With Prostate Cancer Risk

Cited by 18 publications

References 20 publications

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

PSCA s2294008 C>T and rs2976392 G>A polymorphisms contribute to cancer susceptibility: evidence from published studies

Prostate Stem Cell Antigen Polymorphisms and Susceptibility to Gastric Cancer: A Systematic Review and Meta-analysis

Evaluation of 17 genetic variants in association with leukemia in the north Indian population using MassARRAY Sequenom

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