Haploid embryos and embryonic stem cells to produce offspring with predetermined parental genomes in cattle
Lawrence Charles Smith,
Luis Aguila Paredes,
Rafael Vilar Sampaio
et al.
Abstract:Selection strategies are performed post-fertilization when the random combination of paternal and maternal genomes has already occurred. It would be greatly advantageous to eliminate meiotic uncertainty by selecting genetically superior gametes before fertilization. To achieve this goal, haploid embryonic cells and embryonic stem cell lineages could be derived, genotyped, and used to substitute gametes. On the paternal side, androgenetic development can be achieved by removing the maternal chromosomes from the… Show more
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