HAP nanoparticle and substrate surface electrical potential towards bone cells adhesion: Recent results review

Bystrov, Vladimir; Bystrova, Anna; Dekhtyar, Yuri

doi:10.1016/j.cis.2017.05.002

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…Presently, there are publications that demonstrate an influence of HAp electrical charge on cell attachment and proliferation [ 3 , 4 , 5 , 6 ], electrical charge engineering via electrical polarization [ 3 ], sample irradiation [ 4 , 7 , 8 ], modulation of surface roughness [ 6 ], doping [ 9 ], provision of single point defects (theoretical calculations) [ 10 ], and nanostructuring of the surface (Ti) [ 11 ]. There are also examples of the charge influence on wettability of even surfaces (PMMA, roughness 1–2 nm) [ 7 ] and HAp surface with microscale surface roughness [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Fundamentals of Biomaterials Surface Electrical Functionalization

et al. 2020

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This article is focusing on electrical functionalization of biomaterial’s surface to enhance its biocompatibility. It is an overview of previously unpublished results from a series of experiments concerning the effects surface electrical functionalization can have on biological systems. Saccharomyces cerevisiae cells were used for biological experiments. The hydroxyapatite (HAp) specimens were used to investigate influence of structural point defects on the surface electrical charge. Threshold photoelectron emission spectroscopy was used to measure the electron work function of HAp and biologic samples. The density functional theory and its different approximations were used for the calculation of HAp structures with defects. It was shown that the electrical charge deposition on the semiconductor or dielectric substrate can be delivered because of production of the point defects in HAp structure. The spatial arrangements of various atoms of the HAp lattice, i.e., PO4 and OH groups, oxygen vacancies, interstitial H atoms, etc., give the instruments to deposit the electrical charge on the substrate. Immobilization of the microorganisms can be achieved on the even surface of the substrate, characterized with a couple of nanometer roughness. This cells attachment can be controlled because of the surface electrical functionalization (deposition of the electrical charge). A protein layer as a shield for the accumulated surface charge was considered, and it was shown that the protein layer having a thickness below 1 µm is not crucial to shield the electrical charge deposited on the substrate surface. Moreover, the influence of surface charge on the attachment of microorganisms, when the surface roughness is excluded, and the influence of controlled surface roughness on the attachment of microorganisms, when surface charge is constant, were also considered.

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Section: Introductionmentioning

confidence: 99%

Physical Fundamentals of Biomaterials Surface Electrical Functionalization

et al. 2020

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“…Increased molecular weight of the protein may present a 3D conformational hindrance [59] to bind with nHAp. The surface charge may be another important factor [60]. HAp has positive and negative charges, which are beneficial for binding to oppositely charged proteins (including almost all charged proteins).…”

Section: Discussionmentioning

confidence: 99%

Bone Formation on Murine Cranial Bone by Injectable Cross-Linked Hyaluronic Acid Containing Nano-Hydroxyapatite and Bone Morphogenetic Protein

Hachinohe

Taira²,

Hoshi³

et al. 2022

Polymers

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New injection-type bone-forming materials are desired in dental implantology. In this study, we added nano-hydroxyapatite (nHAp) and bone morphogenetic protein (BMP) to cross-linkable thiol-modified hyaluronic acid (tHyA) and evaluated its usefulness as an osteoinductive injectable material using an animal model. The sol (ux-tHyA) was changed to a gel (x-tHyA) by mixing with a cross-linker. We prepared two sol–gel (SG) material series, that is, x-tHyA + BMP with and without nHAp (SG I) and x-tHyA + nHAp with and without BMP (SG II). SG I materials in the sol stage were injected into the cranial subcutaneous connective tissues of mice, followed by in vivo gelation, while SG II materials gelled in Teflon rings were surgically placed directly on the cranial bones of rats. The animals were sacrificed 8 weeks after implantation, followed by X-ray analysis and histological examination. The results revealed that bone formation occurred at a high rate (>70%), mainly as ectopic bone in the SG I tests in mouse cranial connective tissues, and largely as bone augmentation in rat cranial bones in the SG II experiments when x-tHyA contained both nHAp and BMP. The prepared x-tHyA + nHAp + BMP SG material can be used as an injection-type osteoinductive bone-forming material. Sub-periosteum injection was expected.

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“…[ 119 ] However, conventional bone implant materials fail to modulate osteogenesis through controlled electrical properties, which limits their clinical applications. [ 120 ] The intrinsic electronic structure of semiconductive biomaterials can modulate the electrical properties through energy bands, further mediating bone tissue regeneration and improving osseointegration. Therefore, electroactive implants with semiconductor electrical properties have become a hot topic of research.…”

Section: The Electrical Properties Of Semiconductive Biomaterials To ...mentioning

confidence: 99%

Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

Fan,

Ran,

Wang

et al. 2024

Adv Funct Materials

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Bone implant biomaterials are among the most used materials for clinical application. Despite significant advances in biocompatibility and osteoconductivity, conventional biomaterials lack the ability to cope with the pathological microenvironment (inflammation, infection, residual tumors, etc.) during bone repair. Semiconductor implant materials have unique electrical, optical, ultrasound, and thermal response properties, which facilitate non‐invasively and controllably dynamic repair of pathological bone defects. In this review, the design and synthesis of a new generation of semiconductor‐driven bone implant materials are summarized, the mechanism of action of semiconductive biomaterials' functional interfaces and the dynamic repair process of bone tissues are discussed, and new strategies for the problems encountered during clinical osseointegration is provided. Finally, the review outlooks the future of functional semiconductive implants for bone defect repair.

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HAP nanoparticle and substrate surface electrical potential towards bone cells adhesion: Recent results review

Cited by 8 publications

References 47 publications

Physical Fundamentals of Biomaterials Surface Electrical Functionalization

Physical Fundamentals of Biomaterials Surface Electrical Functionalization

Bone Formation on Murine Cranial Bone by Injectable Cross-Linked Hyaluronic Acid Containing Nano-Hydroxyapatite and Bone Morphogenetic Protein

Semiconductive Biomaterials for Pathological Bone Repair and Regeneration

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