Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1
Joyce Wolf van der Meer,
Axelle Larue,
Jan A. van der Knaap
et al.
Abstract:Pathogenic variants in the ubiquitin-specific protease 7 (USP7) gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, which of USP7’s pleiotropic functions are relevant for neurodevelopment remains unclear. Here, we present a combination of quantitative proteomics, transcriptomics and epigenomics to define the USP7 regulatory circuitry during neuronal differentiation. USP7 activity is required for the transcriptional programs that direct both differentiation of embryonic stem cells in… Show more
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