Abstract:The in vitro antibacterial activity of brand‐new fused pyrido[2,1‐a]isoquinoline compounds was investigated. The desired pyrido[2,1‐a]isoquinoline derivatives 5, 9, and 10 were obtained by heating 2‐(6,7‐dimethoxy‐3,4‐dihydroisoquinolin‐1‐yl)acetonitrile 1 with ethylacetate derivatives 2, 6, and 7 in refluxing acetonitrile, while piperidine was present as a catalytic quantity. Under the same conditions, compound 1 was refluxed with compounds 11a–f to give the corresponding compounds 12a–f.
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