Hantaviruses: genome structure, expression and evolution

Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil)

“…Similar to other members of the family, hantaviruses are enveloped viruses with an RNA genome comprised of three negative-sense, single-stranded segments. The large (L) RNA segment encodes an RNA-dependent RNA polymerase, the medium (M) segment encodes two envelope glycoproteins -Gn and Gc -processed from one precursor, and the small (S) segment encodes the nucleocapsid protein (N) (Plyusnin et al, 1996).…”

“…Similar to other members of the family, hantaviruses are enveloped viruses with an RNA genome comprised of three negative-sense, single-stranded segments. The large (L) RNA segment encodes an RNA-dependent RNA polymerase, the medium (M) segment encodes two envelope glycoproteins -Gn and Gc -processed from one precursor, and the small (S) segment encodes the nucleocapsid protein (N) (Plyusnin et al, 1996).Hantaviruses use small mammals as vectors, and in the wild, most of the different hantaviruses have been found to associate predominantly with a specific rodent species that acts as the host in a given geographical region (Plyusnin & Morzunov, 2001). Although sporadic spillover between rodents species has been suggested (Childs et al, 1994;Delfraro et al, 2008;Sousa et al,.…”

Development of an Efficient Method for Recovery of Puumala and Puumala-Related Viruses by Inoculation of Mongolian Gerbils

“…65(11): 1189-1194, 2003 Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia, and hantavirus pulmonary syndrome (HPS) in the Americas [6,16,22,25,26]. It is believed that there is a close relationship between hantaviruses and the specific rodent species in which they establish inapparent and persistant infections [23]. Hantaan (HTN), Seoul (SEO), and Dobrava (DOB) viruses cause a severe form of HFRS and are carried by Murinae rodents [1,2,17,18].…”

“…The segments have been designated, based on their sizes, as large (L), medium (M), and small (S). The L segment encodes a viral RNA polymerase, while M and S encode two surface glycoproteins G1 and G2, and a nucleocapsid protein (NP), respectively [9].PUU virus is the causative agent of a mild form of hemorrhagic fever with renal syndrome, nephropathia epidemica [23]. PUU virus was first discovered in bank voles (C. glareolus) in Puumala, Finland in 1980 [4].…”

“…PUU virus is the causative agent of a mild form of hemorrhagic fever with renal syndrome, nephropathia epidemica [23]. PUU virus was first discovered in bank voles (C. glareolus) in Puumala, Finland in 1980 [4].…”