Hantavirus pulmonary syndrome: prognostic factors for death in reported cases in Brazil

Elkhoury, Mauro da Rosa; Mendes, Wellington da Silva; Waldman, Eliseu Alves; Dias, Juarez Pereira; Carmo, Eduardo Hage; Vasconcelos, Pedro Fernando da Costa

doi:10.1016/j.trstmh.2012.01.002

Cited by 17 publications

(12 citation statements)

References 16 publications

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“…Notably, the mean age of participants in all four study groups (30.9 years) was similar to the mean age of patients who have had HCPS in Brazil (33 years for men and 31 years for women 16 ). Therefore, our surveillance focused on the population with the highest chance of hantavirus infection.…”

supporting

confidence: 61%

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Santos-Júnior

Santos

Barros

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction:Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil. Methods: Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing. Results: High avidity IgG was found in nine of 476 serum samples tested (from 102 patients with clinical manifestations compatible with HCPS, 124 patients with leptospirosis, and 250 healthy rural workers). Conclusions: Serologic evidence of past hantavirus infection in residents of Alagoas State indicates that hantaviruses are present in northeastern Brazil, even in areas silent for HCPS.

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supporting

confidence: 61%

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Santos-Júnior

Santos

Barros

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…Epidemiologic data indicate that more than 70% of HPS-infected people was working or living in agricultural areas, and ~93% were men over the age of 20 [39; 40; 41]. Because the available data are relatively coarse with respect to age distribution, we used the number of rural men older than 14 years in each municipality as the population at risk for HPS.…”

Section: Methodsmentioning

confidence: 99%

Landscape, Environmental and Social Predictors of Hantavirus Risk in São Paulo, Brazil

et al. 2016

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Hantavirus Pulmonary Syndrome (HPS) is a disease caused by Hantavirus, which are negative-sense RNA viruses in the family Bunyaviridae that are highly virulent to humans. Numerous factors modify risk of Hantavirus transmission and consequent HPS risk. Human-driven landscape change can foster transmission risk by increasing numbers of habitat generalist rodent species that serve as the principal reservoir host. Climate can also affect rodent population dynamics and Hantavirus survival, and a number of social factors can influence probability of HPS transmission to humans. Evaluating contributions of these factors to HPS risk may enable predictions of future outbreaks, and is critical to development of effective public health strategies. Here we rely on a Bayesian model to quantify associations between annual HPS incidence across the state of São Paulo, Brazil (1993–2012) and climate variables (annual precipitation, annual mean temperature), landscape structure metrics (proportion of native habitat cover, number of forest fragments, proportion of area planted with sugarcane), and social factors (number of men older than 14 years and Human Development Index). We built separate models for the main two biomes of the state (cerrado and Atlantic forest). In both biomes Hantavirus risk increased with proportion of land cultivated for sugarcane and HDI, but proportion of forest cover, annual mean temperature, and population at risk also showed positive relationships in the Atlantic forest. Our analysis provides the first evidence that social, landscape, and climate factors are associated with HPS incidence in the Neotropics. Our risk map can be used to support the adoption of preventive measures and optimize the allocation of resources to avoid disease propagation, especially in municipalities that show medium to high HPS risk (> 5% of risk), and aimed at sugarcane workers, minimizing the risk of future HPS outbreaks.

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“…From this point forward, other Brazilian States also started to detect cases of HPS in their territories. According to a recent analysis of cases notified to the National System of Disease Notification (SINAN), 14 of the 27 Brazilian States have already notified cases of HPS encompassing all regions of the country [8].…”

Section: Types Of Hantavirus In Brazil and Their Epidemiological Detementioning

confidence: 99%

“…Until October 2001, 134 cases of the disease were confirmed in the country evolving to 1,252 cases in December 2009, an increase of more than 800 % in an eight-year period. The occurrence of cases is seen throughout the year, but the seasons with the highest frequency are winter and spring [8,9].…”

Section: Types Of Hantavirus In Brazil and Their Epidemiological Detementioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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Hantavirus pulmonary syndrome: prognostic factors for death in reported cases in Brazil

Cited by 17 publications

References 16 publications

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Landscape, Environmental and Social Predictors of Hantavirus Risk in São Paulo, Brazil

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

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