Hantavirus infections in humans and commensal rodents in Singapore

Wong, Tze Wai; Chan, Yee Cheun; Joo, Yong Gyu; Lee, Ho Wang; Lee, Pyung Woo; Yanagihara, Richard

doi:10.1016/0035-9203(89)90666-4

Cited by 20 publications

(13 citation statements)

References 15 publications

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“…Sin Nombre [SNV],Andes) are associated with pulmonary syndrome (hantavirus pulmonary syndrome [HPS]) [1]. In Southeast Asia, evidence of hantavirus infections have been reported from Korea, the Philippines, Singapore and Thailand [2][3][4][5]. In Indonesia, a serological study indicated the presence of a Seoul-like virus in wild rats [6].…”

Section: Serological Evidence Of Human Hantavirus Infections In Indonmentioning

confidence: 99%

Serological Evidence of Human Hantavirus Infections in Indonesia

Groen¹,

Suharti²,

Koraka³

et al. 2002

Infection

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Section: Serological Evidence Of Human Hantavirus Infections In Indonmentioning

confidence: 99%

Serological Evidence of Human Hantavirus Infections in Indonesia

Groen¹,

Suharti²,

Koraka³

et al. 2002

Infection

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“…In the late 80's in Singapore, Wong and co-workers found evidence of hantavirus infections in both rodents and humans and one hantavirus strain (R36) was isolated from R. norvegicus [21]. They also analyzed the seroprevalence in patients and found that 8.3% of Dengue Hemorrhagic Fever (DHF) suspects were seropositive to hantaviruses.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of two hantavirus strains from different rattus species in Singapore

Johansson

Yap²,

Low

et al. 2010

Virol J

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BackgroundHantaviruses cause human disease in endemic regions around the world. Outbreaks of hantaviral diseases have been associated with changes in rodent population density and adaptation to human settlements leading to their proliferation in close proximity to human dwellings. In a parallel study initiated to determine the prevalence of pathogens in Singapore's wild rodent population, 1206 rodents were trapped and screened. The findings established a hantavirus seroprevalence of 34%. This paper describes the molecular characterization of hantaviruses from Rattus norvegicus and Rattus tanezumi, the predominant rodents caught in urban Singapore.MethodologyPan-hanta RT-PCR performed on samples of Rattus norvegicus and Rattus tanezumi indicated that 27 (2.24%) of the animals were positive. sequence analysis of the S and M segments established that two different hantavirus strains circulate in the rodent population of Singapore. Notably, the hantavirus strains found in Rattus norvegicus clusters with other Asian Seoul virus sequences, while the virus strains found in Rattus tanezumi had the highest sequence similarity to the Serang virus from Rattus tanezumi in Indonesia, followed by Cambodian hantavirus isolates and the Thailand virus isolated from Bandicota indica.ConclusionsSequence analysis of the S and M segments of hantavirus strains found in Rattus norvegicus (Seoul virus strain Singapore) and Rattus tanezumi (Serang virus strain Jurong TJK/06) revealed that two genetically different hantavirus strains were found in rodents of Singapore. Evidently, together with Serang, Cambodian and Thailand virus the Jurong virus forms a distinct phylogroup. Interestingly, these highly similar virus strains have been identified in different rodent hosts. Further studies are underway to analyze the public health significance of finding hantavirus strains in Singapore rodents.

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“…The 2 earliest documented hantavirus infections in Peru were 2 SEOV HFRS case-patients confirmed by reverse transcription PCR, but both case-patients had fatal HFRS with HCPS ( 9 ), thus further blurring the boundaries between the 2 syndromes. In Southeast Asia, where the wild rat was and is the major reservoir for pathogenic hantaviruses, HFRS with liver involvement, imitating virus hepatitis, was moreover proposed as a new clinical entity ( 10 ). …”

mentioning

confidence: 99%