Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women

Hofmann, Jörg; Führer, A.; Bolz, Michael; Waldschläger-Terpe, Juliane; Meier, Markus; Lüdders, D.; Enders, Martin; Oltmann, Anke; Meisel, Helga; Krüger, Detlev H.

doi:10.1016/j.jcv.2012.07.011

Cited by 17 publications

(27 citation statements)

References 18 publications

(21 reference statements)

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“…They were previously healthy, without any recorded complications during their pregnancies prior to the HFRS diagnosis. Some reports were [8]. Cases of maternal infection are described in China and Korea.…”

Section: Discussionmentioning

confidence: 99%

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Hemorrhagic Fevers with Renal Syndrome Presenting with Pregnancy Interruption

Qyra¹,

Puca²,

Harxhi³

et al. 2017

Journal of Microbiology and Infectious Diseases

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Hemorrhagic fever with renal syndrome is presented with so many different clinical symptoms. It can present mild form of the disease or the severe symptoms. We reported two cases with HFRS, at pregnant women, ended with pregnancy interruption. Both of them had nearly the same age, both 16 weeks pregnant. They presented with fever, malaise, muscle pain and headache. They were febrile when presented at the hospital, hypotensive, hyperemia on the face. They complained about oligo-anuria too. One of them continued to be hypotension, despite the supportive therapy she had an abortion after 8 hours. The other patient had the abortion on the 4 th day of hospitalization. The diagnose was set based on the clinical, epidemiological findings and the serological positive confirmation for IgM Hantavirus by enzyme-linked immunosorbent assay and immunofluorescence assay IFA.The abortion is a rare complication of HFRS in pregnancy. The symptoms are not specific. Early diagnosis and appropriate management are necessary to improve the maternal and fetal outcome. J Microbiol Infect Dis 2017; 7(4):198-201

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Section: Discussionmentioning

confidence: 99%

“…Epidemiologically, they did farm work and this time they bought the food for their livestock in our neighbor country, Kosovo. This country is well known for infections from Hantavirus and reported cases with HFRS [8]. bundles were found pieces of animals (fur, bones).…”

Section: Casementioning

confidence: 99%

Hemorrhagic Fevers with Renal Syndrome Presenting with Pregnancy Interruption

Qyra¹,

Puca²,

Harxhi³

et al. 2017

Journal of Microbiology and Infectious Diseases

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“…Despite this, to date there are very few reports of cases where sensitive methods were used to monitor for infection of the child. The largest European study so far reported two pregnant women with acute Puumala virus infection and two others with acute Dobrava-Belgrade virus infection (28). Despite the fact that all four women became ill, in no case did the maternal infection lead to intrauterine damage or infection of the child (observation period up to 12 months after birth).…”

Section: Vertical Transmissionmentioning

confidence: 99%

Hantaviruses as Zoonotic Pathogens in Germany

Krüger¹,

Ulrich²,

Hofmann³

2013

Deutsches Ärzteblatt International

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“…For HPS, both maternal and fetal deaths may occur from 13 to 29 weeks gestation , but transmission to the surviving children has not been observed. For Puumala hantavirus-caused HFRS, there seems to be a risk of miscarriage when infection occurs during early pregnancy, but vertical hantavirus transmission has not been reported, at least between 14 and 38 weeks gestation (Pettersson et al 2008;Hofmann et al 2012). In studies of rodent reservoirs for hantaviruses, infected females do not vertically transmit virus but can transfer protective antibodies in utero and in milk (Dohmae and Nishimune 1998;Borucki et al 2000;Kallio et al 2006;Kallio et al 2013).…”

Section: Hemorrhagic Fever With Renal Syndrome and Hantavirus Pulmonamentioning

confidence: 99%

Sex and Gender Differences in Infection and Treatments for Infectious Diseases

Klein

Roberts

2015

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This book provides an overview of the underlying sex-based and hormone-based differences in immunity, wound healing and pharmacokinetics, while also exploring how pregnancy affects immunity. The second part of the book shows, for the first time in a single volume, the growing number of infectious diseases for which sex and gender differences are noted, identifies common as well as distinct mechanisms mediating these differences and illustrates how responses to treatments might differ between the sexes. The awareness that males and females differ in their response to specific pathogens as well as to treatments for infectious diseases may yield sex-specific personalized treatments. This book will be of interest to basic scientists and clinicians in the fields of microbiology, immunology and pharmacology. Individuals working in academia, government and industry will also benefit from the information presented

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Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women

Cited by 17 publications

References 18 publications

Hemorrhagic Fevers with Renal Syndrome Presenting with Pregnancy Interruption

Hemorrhagic Fevers with Renal Syndrome Presenting with Pregnancy Interruption

Hantaviruses as Zoonotic Pathogens in Germany

Sex and Gender Differences in Infection and Treatments for Infectious Diseases

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