Hantavirus infection in suspected dengue cases from State of Ceará, Brazil

Lima, Danielle Malta; Júnior, Gilberto Sabino dos Santos; Oliveira, Augusto César Aragão; Fontes, Raissa Matos; Colares, Jeová Keny Baima; Araújo, Fernanda Montenegro de Carvalho; Cavalcanti, Luciano Pamplona de Góes; Fonseca, Benedito Antônio Lopes da; Figueiredo, Luíz Tadeu Moraes; Pompeu, Margarida Maria de Lima

doi:10.1590/s0037-86822011000600031

Cited by 23 publications

(18 citation statements)

References 9 publications

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“…However, an IgG prevalence of 2% was reported in Uberlandia City in Minas Gerais State 12 , which is another hantavirus-endemic region; this is similar to the prevalence found in the present study. The IgG prevalence found in the present study is in keeping with prevalence rates in other regions where HCPS has not been described, such as in the southern parts of Santa Catarina State (2.3%) 13 , in Ceará State (2.8%) 14 , an in Ilhéus City in Bahia State (0.6%) 15 .…”

supporting

confidence: 90%

“…Our fi ndings provide new data regarding hantaviruses in the Northeastern region of Brazil because Alagoas State -as well as the neighboring states on the Northeastern coast (such as the Sergipe and Paraíba States) -is currently considered a silent area for hantavirus infection. Our results, together with those of other studies 14,15 , strongly suggest that at least one species or genotype of hantavirus is circulating in areas previously considered to be hantavirus free. Finally, our fi ndings suggest that routine testing for hantavirus infection should be included in public health systems in the Northeastern states of Brazil as HCPS is probably misdiagnosed in this region.…”

supporting

confidence: 86%

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First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Santos-Júnior

Santos

Barros

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction:Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil. Methods: Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing. Results: High avidity IgG was found in nine of 476 serum samples tested (from 102 patients with clinical manifestations compatible with HCPS, 124 patients with leptospirosis, and 250 healthy rural workers). Conclusions: Serologic evidence of past hantavirus infection in residents of Alagoas State indicates that hantaviruses are present in northeastern Brazil, even in areas silent for HCPS.

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supporting

confidence: 90%

supporting

confidence: 86%

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

Santos-Júnior

Santos

Barros

et al. 2017

Rev. Soc. Bras. Med. Trop.

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“…However, Behera, et al, considered a patient who was positive for the ELISA to be a case of co-infection, showing anti-dengue and antiLeptospira antibodies (27). Thirty-five patients remained without a specific laboratory diagnosis, suggesting that they had been infected by other (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

La evidencia serológica de leptospirosis en pacientes con sospecha clínica de dengue en el estado de Ceará, Brasil

et al. 2015

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“…It is possible that most of the infections in Sinop, especially those manifesting as mild forms of the disease, might remain undiagnosed. In dengueendemic areas, such as Sinop, fever due to other arboviruses or even hantaviruses can be misdiagnosed as dengue based only on clinical-epidemiological data (2) (8) . Taking this into account, it is important to screen for hantavirus in acute febrile illness patients using rapid and sensitive diagnostic methods.…”

mentioning

confidence: 99%

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

Vieira

Silva

Barreto

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:In Brazil, Mato Grosso (MT) has the highest number of hantavirus cardiopulmonary syndrome cases. Our study aimed to identify anti-hantavirus antibodies in the sera of patients from Sinop, MT, presenting with acute febrile illness. Methods: A retrospective analysis of data for 198 sera samples assessed using enzyme-linked immunosorbent assay (ELISA) was conducted. Results: Immunoglobulins G (IgGs) against the hantavirus nucleoprotein were found in 13.6% of the tested sera. No sample had immunoglobulin M (IgM) antibodies to hantavirus. Seropositivity occurred mainly in female residents in urban areas who worked around the household. Conclusions: Our findings suggest circulation of hantavirus in Sinop.Keywords: Zoonosis. Serosurvey study. Hantavirus.Hantaviruses (genus Hantavirus, family Bunyaviridae) are emerging zoonotic viruses of great importance for public health. In South America, the rodents of the Sigmodontinae subfamily are reservoirs of these viruses. Some hantaviruses infect humans, causing either hemorrhagic fever with renal syndrome (HFRS) and/or hantavirus cardiopulmonary syndrome (HCPS) (1) .The first cases of HCPS diagnosed in Brazil occurred in 1993. Since then, more than 1,920 cases of hantavirus have been notified in all Brazilian regions, with a case fatality rate of up to 39.5%. Mato Grosso (MT) is the leading state for HCPS cases and accounts for 16.1% of the total notified cases in Brazil. In a previous study conducted in the municipality of Sinop, Mato Grosso State, we carried out an epidemiological surveillance for arboviruses in 198 sera samples from patients presenting with acute febrile illness and clinical-epidemiological diagnoses of dengue. The results showed 46 samples positive for arboviruses. However, it was intriguing that more than 70% of the patients did not have dengue or other arbovirus infections that were tested for (2) . To address the possibility of hantavirus infection, we investigated the presence of antibodies against the hantavirus nucleoprotein in these febrile patients.Sinop is a municipality located 503km from the capital Cuiabá, in a geographical transition zone between a savannah and rainforest. The city was founded in 1974 and currently has an estimated population of approximately 130,000 inhabitants with 17.1% of them living in rural areas. The economic activities include an intensive agriculture based on the grain production, animal husbandry, logging, and human services. All of the sera analyzed in this study were part of the serum bank of the Laboratory of Immunology and Molecular Biology of Universidade Federal de Mato Grosso (UFMT), Campus of Sinop, which have been previously described in detail (2) . At the time of blood collection, the patients filled out a questionnaire that contained their epidemiological data, sex, age, occupation, address and region of birth, as well as information about any contact with rural or forested areas, and contact with rodents. These data were collected to analyze the risk factors associated with infect...

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Hantavirus infection in suspected dengue cases from State of Ceará, Brazil

Cited by 23 publications

References 9 publications

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil

La evidencia serológica de leptospirosis en pacientes con sospecha clínica de dengue en el estado de Ceará, Brasil

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

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