Hantavirus Infection in Istanbul, Turkey

Öncül, Oral; Atalay, Yunus Oktay; Önem, Yalçın; Turhan, Vedat; Acar, Ali; Uyar, Yavuz; Çağlayık, Dilek Yağcı; Özkan, Sezai; Görenek, Levent

doi:10.3201/eid1702.100663

Cited by 27 publications

(20 citation statements)

References 5 publications

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“…The current study of rodents in Turkey identified DOBV genotype Dobrava (DOBV-Af) as a potential causative agent of the hantavirus outbreak on the Black Sea coast of Turkey. This conclusion is in agreement with previous findings in patients from this region ( 6 , 8 , 10 ). …”

Section: Discussionsupporting

confidence: 94%

Dobrava-Belgrade Virus inApodemus flavicollisandA. uralensisMice, Turkey

Öktem¹,

Uyar²,

Dinçer³

et al. 2014

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 94%

Dobrava-Belgrade Virus inApodemus flavicollisandA. uralensisMice, Turkey

Öktem¹,

Uyar²,

Dinçer³

et al. 2014

Emerg. Infect. Dis.

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“…The causative agent was DOBV in most of the published cases. (Kaya et al, ; Oncul et al, ; Sarıgüzel et al, ) . In the current outbreak, apart from the index case (who died 48 hr after hospital admission) and the second case (he was transferred to another hospital, and follow‐up serum samples could not be obtained) the causative agent was indicated as PUUV by detecting IgM antibodies against PUUV at the early stage of disease and the presence of elevated levels of IgG antibodies against PUUV in paired serum samples of 22 cases.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Çelebi

Öztoprak

Öktem

et al. 2019

Zoonoses and Public Health

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Background Some of the hantavirus species in Euro‐Asia cause haemorrhagic fever with renal syndrome (HFRS) in humans. The first documented human hantavirus infection in Turkey was diagnosed in 2009. This report describes the dynamics of the first hantavirus outbreak that emerged in humans in the Western Black Sea Region of Turkey. Methods All the suspected cases of hantavirus infection were admitted to the Infectious Diseases and Clinical Microbiology Department at the Zonguldak Bülent Ecevit University Hospital in Zonguldak, Turkey. The patients were carefully interviewed, examined and evaluated using routine laboratory tests and hantavirus diagnostic tools. Hantavirus‐reactive antibodies (IgM and IgG) in serum samples were detected via enzyme immune assay (EIA) and immunofluorescence assay (IFA) in the acute and convalescence stages of the disease. The presence of hantavirus ribonucleic acid (RNA) was analysed via reverse transcription polymerase chain reaction (RT‐PCR) in serum and urine samples. A focus reduction neutralization test (FRNT) was performed to confirm specific hantavirus serotypes. In addition, a case–control study was conducted to identify possible risk factors for hantavirus transmission in the outbreak area. A control group was composed of asymptomatic individuals who were seronegative for hantavirus IgM and IgG and living in the outbreak area. Results A total of 55 suspected cases of hantavirus infection were admitted to the inpatient clinic between February and June of 2009. Twenty‐four patients were diagnosed with acute HFRS via EIA or IFA. In 22 of the 24 infected patients, Puumala virus (PUUV) was identified as the causative hantavirus type by detecting IgM in the acute stage and an increase in the IgG level in follow‐up serum samples. PUUV was also verified as the infecting agent by FRNT in two of the 24 cases. Among the 24 laboratory‐confirmed HFRS cases, 21 (87.5%) were males and 3 (12.5%) were females, and the mean age was 45.92 years (standard deviation ± 16.90 years). Almost all these individuals were living in villages or rural areas. The 24 HFRS cases were matched with 26 healthy controls for statistical analyses and according to binary logistic regression analysis, and dealing with rodent control activities in gardens or in annexes of their homes (p = 0.021 and Odds ratio [OR] = 17.11) and being male (p = 0.019 and OR = 22.37) were detected as statistically significant risk factors for hantavirus infection. The most commonly observed clinical complaints were fatigue (95.8%), shivering (91.7%), fever (87.1%), headache (70.8%) and nausea (70.8%). Haemodialysis was required for four patients (16.7%). Except for the first case diagnosed with acute hantavirus infection, no patient died. The mean delay time to hospital admission from initiation of symptoms was 5.3 days, the mean duration of febrile days was 2.6 days, and the mean duration of hospital stay was 8.5 days. Conclusion Hantaviruses are circulating in Turkey and causing sporadic or epidemic infection in humans. Addit...

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“…Intriguingly, mice of this species are present across Europe but seem to be DOBV-free in Western and Northern Europe. Besides SE Europe, DOBV-Af has been found in several countries in Central Europe such as the Czech Republic [52, 81], Slovakia [73, 83], Hungary [40, 61] and recently also in Turkey [46, 64]. In Central and Eastern Europe (Germany, Slovakia, European Russia, Hungary, Estonia, and other countries), the striped field mouse is the dominant DOBV reservoir.…”

Section: Dobv Hosts and Evolutionmentioning

confidence: 99%

Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics

et al. 2012

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Dobrava-Belgrade virus (DOBV) is a human pathogen that has evolved in, and is hosted by, mice of several species of the genus Apodemus. We propose a subdivision of the species Dobrava-Belgrade virus into four related genotypes – Dobrava, Kurkino, Saaremaa, and Sochi – that show characteristic differences in their phylogeny, specific host reservoirs, geographical distribution, and pathogenicity for humans.

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Hantavirus Infection in Istanbul, Turkey

Cited by 27 publications

References 5 publications

Dobrava-Belgrade Virus inApodemus flavicollisandA. uralensisMice, Turkey

Dobrava-Belgrade Virus inApodemus flavicollisandA. uralensisMice, Turkey

Dynamics of Puumala hantavirus outbreak in Black Sea Region, Turkey

Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics

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