Hantavirus infection in Brazilian patients from Recife with suspected leptospirosis

Hindrichsen, S.; Andrade, Aureo; Clément, Jan; Leirs, Herwig; Kenna, Paula Mc; Matthys, Patrick; Neild, Guy H.

doi:10.1016/0140-6736(93)92523-v

Cited by 41 publications

(41 citation statements)

References 3 publications

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“…The differential diagnosis of HPS can be challenging in scenarios where dengue and leptospirosis epidemics occur often, as seen in a great number of Brazilian cities [2,[31][32][33]. Other conditions can also cause difficulties in diagnosis like severe respiratory disease caused by influenza and atypical pneumonias as well as acute febrile illness, like malaria, yellow fever and spotted fever, which also require the physician's attention, especially in tropical areas [34].…”

Section: Hantavirus Pulmonary Syndrome In Brazilmentioning

confidence: 99%

“…The first serological evidence of this disease in humans in the Americas was reported during an outbreak of leptospirosis in 1990 in the Brazilian city of Recife, Pernambuco State, when serological diagnosis of two cases were done during a leptospirosis epidemic [2]. In South America the main affected countries are Brazil, Argentina, Chile and Paraguay, and Hantavirus pulmonary syndrome (HPS) is the predominant clinical manifestation [3].…”

Section: Introductionmentioning

confidence: 99%

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Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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Section: Hantavirus Pulmonary Syndrome In Brazilmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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“…A ampla distribuição desses vírus em roedores domésticos e peridomésticos sugeria a existência da hantavirose em regiões situadas fora dos seus limites geográficos até então conhecidos LEE et al, 1982). Ainda mais, outros estudos soroepidemiológicos para detecção da infecção por Hantavirus confirmaram a ocorrência da infecção no Brasil (HINDRICHSEN et al, 1993;IVERSSON et al, 1994;NUNES-ARAUJO et al, 1999;HOLMES et al;ROMANO-LIBER et al, 2001;MENDES et al, 2004. …”

Section: Spcvhunclassified

“…Ainda, outros estudos soroepidemiológicos para a detecção da infecção por Hantavirus foram realizados, confirmando a ocorrência dessas no Brasil (HINDRICHSEN et al, 1993;IVERSSON et al, 1994;NUNES-ARAUJO et al, 1999;HOLMES et al, 2000;ROMANO-LIBER et al, 2001;MENDES et al, 2004 …”

Section: Hantaviroses No Brasilunclassified

“…Coqueiros em época anterior à sua descrição nas Américas, corroborando outros estudos que apontavam para o mesmo achado em áreas diferentes do Brasil (HINDRICHSEN et al, 1993;IVERSSON et al, 1994;NUNES-ARAUJO et al, 1999;HOLMES et al, 2000;ROMANO-LIBER et al, 2001;MENDES et al, 2004). Muito provavelmente, os casos mais graves foram confundidos com outras doenças com as quais a hantavirose guarda semelhanças do ponto de vista clinico.…”

Section: Análise Das Informaçõesunclassified

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Estudo sorológico retrospectivo sobre a hantavirose no município de Cássia dos Coqueiros, no período de 1986 a 1991

Badra¹

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Serological survey of hantavirus in Jardinopolis county, Brazil

Sousa

Badra

Pane³

et al. 2003

Journal of Medical Virology

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Hantaviruses are the causative agents of severe human diseases such as Cardiopulmonary Syndrome (CPS), described for the first time in 1993. Approximately 200 cases of this emergent disease were reported in Brazil until August 2002, with a 40% fatality rate. In May 2001, a hantavirus serologic survey was carried out among 15-70-year-old inhabitants of Jardinopolis County, State of São Paulo, Brazil. Blood samples of 818 inhabitants from urban and rural areas were collected by digitopuncture and IgG antibodies, detected by an indirect enzyme-linked immunosorbent assay (ELISA) to the N recombinant protein of Andes hantavirus, were found in 14.3% of the samples, showing that this infection is common in Jardinopolis County, especially among adults irrespective of sex, profession, history of contact with rodents, or history of severe pneumonia. The results of the survey do not corroborate the idea that hantavirus infections are associated to rural activity and rodent contact, as observed with 20 Cardiopulmonary Syndrome cases occurred in the same region. Hantaviruses may be causing unrecognized infections, either asymptomatic or clinically nonspecific in addition to the syndrome. It may also be the case that more than one hantavirus type could be circulating in this region, causing mostly benign infections.

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Hantavirus infection in Brazilian patients from Recife with suspected leptospirosis

Cited by 41 publications

References 3 publications

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Estudo sorológico retrospectivo sobre a hantavirose no município de Cássia dos Coqueiros, no período de 1986 a 1991

Serological survey of hantavirus in Jardinopolis county, Brazil

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