Hantavirus in African Wood Mouse, Guinea

Klempa, Boris; Fichet‐Calvet, Elisabeth; Lecompte, Émilie; Auste, Brita; Анискин, В. М.; Meisel, Helga; Denys, Christiane; Koivogui, Lamine; Meulen, Jan ter; Krüger, Detlev H.

doi:10.3201/eid1205.051487

Cited by 278 publications

(258 citation statements)

References 15 publications

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“…Ten (1.4%), 17 (2.4%), and four (0.6%) voles were seropositive to hantaviruses, LCMV, and LV, respectively (results are summarized in Table 1). RTPCRs specific for respective viruses were conducted on lung samples from individuals seropositive to hantavirus and LCMV (also some samples from seronegative voles within the same sites) (Klempa et al 2006, Vieth et al 2007, and on liver samples from individuals seropositive to LV (Donoso Mantke et al 2007). All results were negative (data not shown).…”

Section: Resultsmentioning

confidence: 99%

Serological Survey of Rodent-Borne Viruses in Finnish Field Voles

Forbes

Voutilainen

Jääskeläinen

et al. 2014

Vector-Borne and Zoonotic Diseases

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In northern Europe, rodent populations display cyclic density fluctuations that can be correlated with the human incidence of zoonotic diseases they spread. During density peaks, field voles (Microtus agrestis) become one of the most abundant rodent species in northern Europe, yet little is known of the viruses they host. We screened 709 field voles, trapped from 14 sites over 3 years, for antibodies against four rodent-borne, potentially zoonotic viruses or virus groups-hantaviruses, lymphocytic choriomeningitis virus (LCMV), Ljungan virus (LV), and orthopoxviruses (OPV). Antibodies against all four viruses were detected. However, seroprevalence of hantaviruses, LV, and LCMV was low. OPV antibodies (most likely cowpox) were more common but restricted geographically to southeastern Finland. Within these sites, antibody prevalence showed delayed density dependence in spring and direct density dependence in fall. Higher seroprevalence was found in spring than fall. These results substantially increase knowledge of the presence and distribution of viruses of field voles in Finland, as well as CPXV infection dynamics.

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Section: Resultsmentioning

confidence: 99%

Serological Survey of Rodent-Borne Viruses in Finnish Field Voles

Forbes

Voutilainen

Jääskeläinen

et al. 2014

Vector-Borne and Zoonotic Diseases

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“…Laboratory tests indicated haematuria, elevated transaminases and thrombocytopenia and serologically confirmed HFRS. In addition, SEOV RNA was detected in her blood by nested RT-PCR [26] with 100% sequence identity (partial L segment) to Cherwell SEOV.…”

Section: Cheltenham Householdmentioning

confidence: 99%

High prevalence of Seoul hantavirus in a breeding colony of pet rats

et al. 2017

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SUMMARYAs part of further investigations into three linked haemorrhagic fever with renal syndrome (HFRS) cases in Wales and England, 21 rats from a breeding colony in Cherwell, and three rats from a household in Cheltenham were screened for hantavirus. Hantavirus RNA was detected in either the lungs and/or kidney of 17/21 (81%) of the Cherwell rats tested, higher than previously detected by blood testing alone (7/21, 33%), and in the kidneys of all three Cheltenham rats. The partial L gene sequences obtained from 10 of the Cherwell rats and the three Cheltenham rats were identical to each other and the previously reported UK Cherwell strain. Seoul hantavirus (SEOV) RNA was detected in the heart, kidney, lung, salivary gland and spleen (but not in the liver) of an individual rat from the Cherwell colony suspected of being the source of SEOV. Serum from 20/20 of the Cherwell rats and two associated HFRS cases had high levels of SEOV-specific antibodies (by virus neutralisation). The high prevalence of SEOV in both sites and the moderately severe disease in the pet rat owners suggest that SEOV in pet rats poses a greater public health risk than previously considered.

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“…2a, b), following the methodology described above. This analysis showed that MAYOV clusters within the Thailand hantavirus clade closer to the isolates circulating in the Indian Ocean, South-East Asia (Hugot et al, 2006;Plyusnina et al, 2009;Johansson et al, 2010) and Madagascar (Reynes et al, 2014), rather than the Murinae-associated hantaviruses circulating in continental Africa (Klempa et al, 2006(Klempa et al, , 2012Witkowski et al, 2014). The data suggested that both MAYOV and Anjozorobe virus, the closest variant within the Thailand hantavirus clade, may have resulted from a westward expansion of an ancestral South-East Asian hantavirus introduced with R. rattus (Cheke & Hume, 2008;Tollenaere et al, 2010).…”

mentioning

confidence: 91%

“…The following reverse transcription (RT)-PCRs were performed for hantavirus screening: (i) consensus RT-PCR using degenerate primers targeting the L gene (Klempa et al, 2006) for all samples; and (ii) specific RT-PCRs for insectivore hantaviruses targeting both the L and S segments (Kang et al, 2009) for insectivore samples. Sera from positive pooled RNA were subsequently screened independently by RT-PCR.…”

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confidence: 99%

Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

Filippone

Castel

Murri

et al. 2016

Journal of General Virology

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Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Ré union and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Ré union island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases. Received 5 November 2015 Accepted 27 February 2016Viruses belonging to the genus Hantavirus, family Bunyaviridae, are negative-sense tri-segmented RNA viruses, with L, M and S segments encoding the RNA-dependent RNA polymerase, glycoproteins Gc and Gn, and nucleoprotein, respectively. Hantaviruses are known to circulate in small mammals (rodents, shrews, moles and bats) in Europe, Asia, America and, more recently discovered, Africa. Infection of humans occurs through inhalation of rodents' aerosolized excreta and can cause two severe pathologies: Haemorrhagic Fever with Renal Syndrome (HFRS) in Asia and Europe, and Hantavirus Cardiopulmonary Syndrome (HCPS), in the Americas (Kruger et al., 2015).An extensive capture of almost 4000 wild and domestic mammals was conducted in La Réunion, Maurice and Mayotte islands between 2006 and 2007, during Chikungunya virus (CHIKV) outbreaks. Although a low seroprevalence against CHIKV was detected in several non-human primates and rats (Vourc'h et al., 2014), the sample collection was used for virus hunting. Here, we report on an investigation of hantaviruses in 642 small wild mammals captured in La Réunion (193 Rattus rattus, 44 Rattus norvegicus, 67 Mus musculus, 133 Suncus murinus, 45 Tenrec ecaudatus) and Mayotte (160 Rattus rattus) islands. The GenBank/EMBL/DDBJ accession numbers for the sequences determined in this study are KT719320-KT719370 (N gene coding sequence), KT779091-KT779093 and KU587796 (S, M and L complete coding sequence).One supplementary figure is available with the online Supplementary Material.

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Hantavirus in African Wood Mouse, Guinea

Cited by 278 publications

References 15 publications

Serological Survey of Rodent-Borne Viruses in Finnish Field Voles

Serological Survey of Rodent-Borne Viruses in Finnish Field Voles

High prevalence of Seoul hantavirus in a breeding colony of pet rats

Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

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