Hantaan Virus Reduces the von Willebrand Factor in Human Umbilical Vein Endothelial Cells

Cho, Michael; Hwang, Ji-Young; Park, Hosun

doi:10.4167/jbv.2007.37.4.225

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Immunofluorescence assay (IFA) was performed as previously described (Cho et al, 2007). Briefly, infected or non-infected cells were treated with human anti-HTNV (HFRS patient's serum) or rabbit anti-Ang-1 IgG (Abcam).…”

Section: Methodsmentioning

confidence: 99%

Reduced expression of angiopoietin-1 in Hantaan virus-infected human umbilical vein endothelial cell increases their permeability

Hwang¹,

Park²,

Hong³

et al. 2009

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Hemorrhagic fever with renal syndrome (HFrS) caused by Hantaan virus (HTnV) is characterized by vascular hemorrhage and acute renal failure. Angiopoietin-1 (Ang-1) is a glycoprotein that maintains vessel integrity and reduces endothelial permeability. we found that in HTnV-infected human umbilical vein endothelial cells (HUVECs) the levels of Ang-1 mrnA and protein were reduced on days 2 and 3 post-infection (p.i.), when endothelial permeability was increased. The HTnV-stimulated permeability was reduced by treatment of HUVECs with Ang-1. The plasma Ang-1 level was lower in HFrS patients than in healthy persons. Paired plasma samples of HFrS patients revealed markedly lower Ang-1 levels during the acute phase of HFrS as compared to the convalescent phase. These findings suggested that HTnV reduced the Ang-1 expression in endothelial cells that might play an important role in the increase of vascular permeability in HFrS.

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Section: Methodsmentioning

confidence: 99%

Reduced expression of angiopoietin-1 in Hantaan virus-infected human umbilical vein endothelial cell increases their permeability

Hwang¹,

Park²,

Hong³

et al. 2009

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“…Activation of coagulation : Decreased expression of von Willebrand (VW) factor in HNTV-infected endothelial cells was demonstrated by Cho et al [ 90 ]. Also, we demonstrated the inhibition of thrombospondin 1 in HNTV-infected endothelial cells in vitro [ 91 ].…”

Section: Pathogenesis Of Orthohantavirus Infectionsmentioning

confidence: 99%

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Sehgal

Mehta

Sahay

et al. 2023

Viruses

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Hemorrhagic Fever with Renal Syndrome (HFRS) is the most frequently diagnosed zoonosis in Asia. This zoonotic infection is the result of exposure to the virus-contaminated aerosols. Orthohantavirus infection may cause Hemorrhagic Fever with Renal Syndrome (HRFS), a disease that is characterized by acute kidney injury and increased vascular permeability. Several species of orthohantaviruses were identified as causing infection, where Hantaan, Puumala, and Seoul viruses are most common. Orthohantaviruses are endemic to several Asian countries, such as China, South Korea, and Japan. Along with those countries, HFRS tops the list of zoonotic infections in the Far Eastern Federal District of Russia. Recently, orthohantavirus circulation was demonstrated in small mammals in Thailand and India, where orthohantavirus was not believed to be endemic. In this review, we summarized the current data on orthohantaviruses in Asia. We gave the synopsis of the history and diversity of orthohantaviruses in Asia. We also described the clinical presentation and current understanding of the pathogenesis of orthohantavirus infection. Additionally, conventional and novel approaches for preventing and treating orthohantavirus infection are discussed.

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Direct and indirect effects of Puumala hantavirus on platelet function

Schrottmaier,

Schmuckenschlager,

Thunberg

et al. 2024

Thrombosis Research

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Hantaan Virus Reduces the von Willebrand Factor in Human Umbilical Vein Endothelial Cells

Cited by 3 publications

References 26 publications

Reduced expression of angiopoietin-1 in Hantaan virus-infected human umbilical vein endothelial cell increases their permeability

Reduced expression of angiopoietin-1 in Hantaan virus-infected human umbilical vein endothelial cell increases their permeability

Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention

Direct and indirect effects of Puumala hantavirus on platelet function

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