Hans-Lukas Teuber and ‘The Riddle of Frontal Lobe Function in Man’ as Published in The Frontal Granular Cortex and Behavior (1964)

Bigler, Erin D.

doi:10.1007/s11065-009-9086-1

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…The hippocampus is critically involved in relational memory abilities [Cohen and Eichenbaum, 1993; Eichenbaum and Cohen, 2001] and we have previously shown that MRE derived measures of HC viscoelasticity are sensitive to relational memory success among healthy young adults [Schwarb et al, 2016; Schwarb et al, 2017]. Derived primarily from behavioral and lesion studies, the gold standard for identifying dissociable and selective structure-function relationships is the double-dissociation [Bigler, 2009; Fama and Sullivan, 2014; Freedman et al, 1984; Teuber, 1955]. Generally, a double dissociation necessitates that brain region A relates to or impacts cognitive process X, but not (or to a significantly lesser extent) cognitive process Y; while brain region B relates to or impacts cognitive process Y, but not (or to a significantly lesser extent) cognitive process X.…”

Section: Introductionmentioning

confidence: 99%

Double dissociation of structure-function relationships in memory and fluid intelligence observed with magnetic resonance elastography

et al. 2018

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Brain tissue mechanical properties, measured in vivo with magnetic resonance elastography (MRE), have proven to be sensitive metrics of neural tissue integrity. Recently, our group has reported on the positive relationship between viscoelasticity of the hippocampus and performance on a relational memory task in healthy young adults, which highlighted the potential of sensitive MRE measures for studying brain health and its relation to cognitive function; however, structure-function relationships outside of the hippocampus have not yet been explored. In this study, we examined the relationships between viscoelasticity of both the hippocampus and the orbitofrontal cortex and performance on behavioral assessments of relational memory and fluid intelligence. In a sample of healthy, young adults (N = 53), there was a significant, positive relationship between orbitofrontal cortex viscoelasticity and fluid intelligence performance (r = 0.42; p = .002). This finding is consistent with the previously reported relationship between hippocampal viscoelasticity and relational memory performance (r = 0.41; p = .002). Further, a significant double dissociation between the orbitofrontal-fluid intelligence relationship and the hippocampal-relational memory relationship was observed. These data support the specificity of regional brain MRE measures in support of separable cognitive functions. This report of a structure-function relationship observed with MRE beyond the hippocampus suggests a future role for MRE as a sensitive neuroimaging technique for brain mapping.

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Section: Introductionmentioning

confidence: 99%

Double dissociation of structure-function relationships in memory and fluid intelligence observed with magnetic resonance elastography

et al. 2018

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“…Before contemporary neuroimaging, invasive procedures like cerebral arteriography and pneumoencephalography could show a two-dimensional view of where certain vascular pathologies may be seen or an outline of the ventricular system or even a tumor, but no direct view of the brain was possible (Bigler, 2017). Neuropsychologists like Hans-Lukas Teuber (see Bigler, 2009), who studied World War II and Korean War traumatic brain injury (TBI) victims, used standard skull X-ray films of soldiers with through-and-through penetrating wounds that could be visualized in the X-ray to differentiate anterior versus posterior lesion effects on certain neuropsychological functions, but again the technique provided no direct view of the brain or its pathways. In the classic studies by Brenda Milner, lobular pathology was outlined postsurgically based on neurosurgical reports (see Walusinski et al, 2019), such that lobe-by-lobe and hemisphere-by-hemisphere analyses could be undertaken.…”

Section: Historical Perspective: White Matter Neural Connectivity And...mentioning

confidence: 99%

Diffusion imaging and fiber mapping.

Bigler¹,

Goodrich-Hunsaker²

2023

APA Handbook of Neuropsychology, Volume 2: Neuroscience and Neuromethods (Vol. 2).

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“…To achieve the initial goals of characterizing the neurocognitive and neurobehavioral correlates of the brain when damaged, neuropsychology emerged mid-20th century in an era where non-invasive neuroimaging did not exist. Out of necessity, the founders of this field had to be creative in terms of natural observation and capitalized on coarse measures of brain damage, like aphasia, hemiplegia or hemisensory deficits from TBI and other disorders (i.e., stroke, neoplasm) to standardize certain neuropsychological measures (see Bigler, 2009 ). Using a normative approach with test scores established in age-typical healthy controls, neuropsychological assessment techniques were developed where the influence of brain damage/dysfunction was viewed in terms of discrepant performance from the norm for a particular measure like memory or perceptual processing (Lezak et al, 2012 ).…”

Section: The Limits Of Traditional Neuropsychological Assessmentmentioning

confidence: 99%

Systems Biology, Neuroimaging, Neuropsychology, Neuroconnectivity and Traumatic Brain Injury

Bigler

2016

Front. Syst. Neurosci.

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The patient who sustains a traumatic brain injury (TBI) typically undergoes neuroimaging studies, usually in the form of computed tomography (CT) and magnetic resonance imaging (MRI). In most cases the neuroimaging findings are clinically assessed with descriptive statements that provide qualitative information about the presence/absence of visually identifiable abnormalities; though little if any of the potential information in a scan is analyzed in any quantitative manner, except in research settings. Fortunately, major advances have been made, especially during the last decade, in regards to image quantification techniques, especially those that involve automated image analysis methods. This review argues that a systems biology approach to understanding quantitative neuroimaging findings in TBI provides an appropriate framework for better utilizing the information derived from quantitative neuroimaging and its relation with neuropsychological outcome. Different image analysis methods are reviewed in an attempt to integrate quantitative neuroimaging methods with neuropsychological outcome measures and to illustrate how different neuroimaging techniques tap different aspects of TBI-related neuropathology. Likewise, how different neuropathologies may relate to neuropsychological outcome is explored by examining how damage influences brain connectivity and neural networks. Emphasis is placed on the dynamic changes that occur following TBI and how best to capture those pathologies via different neuroimaging methods. However, traditional clinical neuropsychological techniques are not well suited for interpretation based on contemporary and advanced neuroimaging methods and network analyses. Significant improvements need to be made in the cognitive and behavioral assessment of the brain injured individual to better interface with advances in neuroimaging-based network analyses. By viewing both neuroimaging and neuropsychological processes within a systems biology perspective could represent a significant advancement for the field.

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Hans-Lukas Teuber and ‘The Riddle of Frontal Lobe Function in Man’ as Published in The Frontal Granular Cortex and Behavior (1964)

Cited by 7 publications

References 33 publications

Double dissociation of structure-function relationships in memory and fluid intelligence observed with magnetic resonance elastography

Double dissociation of structure-function relationships in memory and fluid intelligence observed with magnetic resonance elastography

Diffusion imaging and fiber mapping.

Systems Biology, Neuroimaging, Neuropsychology, Neuroconnectivity and Traumatic Brain Injury

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