Handy Hints About Raynaud's Phenomenon in Children: A Critical Review

Rigante, Donato; Fastiggi, Michele; Ricci, Francesco; D’Errico, Francesca; Bracci, Benedetta; Guerriero, Cristina

doi:10.1111/pde.13129

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…She also reported suffering from Raynaud's syndrome since childhood, for which she does not receive any specific therapy [ 9 ]. The patient denied any previous history of trauma or other abdominal surgery.…”

Section: Case Reportmentioning

confidence: 99%

Incidental finding of intrathoracic caudate lobe of the liver associated with an arterovenous malformation

D’Errico

Laudazi

Volpe

et al. 2023

Radiology Case Reports

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Section: Case Reportmentioning

confidence: 99%

Incidental finding of intrathoracic caudate lobe of the liver associated with an arterovenous malformation

D’Errico

Laudazi

Volpe

et al. 2023

Radiology Case Reports

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“…Finally, the arteries dilate, causing the return of blood flow and post-ischemic hyperemia (redness). The hands, feet, ears, nose and nipples can be affected (1). RP prevalence increases with age in children, especially among the girls (2).…”

Section: Introductionmentioning

confidence: 99%

“…Risk factors for RP in children are living in cold climates, female sex, and positive family history. Some conditions associated with RP may be listed as rheumatological disorders (scleroderma, systemic lupus erythematosus, juvenile idiopathic arthritis, dermatomyositis, mixed connective tissue disease, Sjogren's syndrome, Takayasu arteritis), mechanical injury, arterial diseases, hematological diseases, infection, medication, and exposure to chemical agents (1,8). The clinical symptoms of the underlying pathology are usually present at the time of examination.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Primary and Secondary Raynaud’s Phenomenon in Childhood

Sezer¹,

Çelikel²,

Aydın³

et al. 2022

Turkish Journal of Pediatric Disease

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Objective: To evaluate the clinical, laboratory and capillaroscopic findings of pediatric patients with Raynaud's phenomenon.Material and Methods: Ninety-five pediatric patients who were diagnosed with Raynaud's phenomenon between January 2014 and January 2021, were retrospectively examined. The demographic data, laboratory parameters and capillaroscopic findings of the patients were recorded. The capillaroscopic findings of the patients were classified as normal, nonspecific abnormalities and scleroderma pattern.Results: Primary Raynaud's phenomenon was present in 84 (88.5%) patients, and secondary Raynaud's phenomenon was present in 11 (11.5%). Arthralgia, arthritis, rash and recurrent fever were significantly more common in secondary Raynaud's phenomenon (p=0.001, p=<0.001, p=0.01, p=0.035, respectively). Antinuclear antibody positivity >1/320 was significantly higher in the patients with secondary Raynaud's phenomenon (p=0.01). Of the 40 patients who had capillaroscopy performed, 2 had a scleroderma pattern, 19 had nonspecific changes, and 19 had normal nailfold capillaroscopic findings. Capillary irregularity, tortuous capillaries and increased branching were significantly higher in the secondary Raynaud's phenomenon cases (p=0.015, p=0.015, p=0.003, respectively). Conclusion:Having antinuclear antibody titer >1/320 and detection of capillary irregularity, tortuous capillaries and increased branching may be useful in distinguishing primary and secondary Raynaud's phenomenon.

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“…Primary RP has an earlier onset (median age at onset is around 14 years) and is characterized by milder symptoms. 17 Secondary RP often has a later onset (usually after the age of 40, rare in children) with more severe symptoms, which leads to complications such as digital ulcers, finger necrosis, and amputation or associated infection and osteomyelitis. 17 Early detection of SSc or any other cause of secondary RP could allow early treatment and better patient outcomes.…”

mentioning

confidence: 99%

Recent advances in the workup and management of Raynaud’s phenomenon

Lis‐Święty

2019

Polish Archives of Internal Medicine

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oxide synthase 1 gene as significantly correlated with RP in the general population. 4 Major risk factors for primary RP include, in addition to the female sex and family history, a previous sensation of cold hands, migraine, cardiovascular diseases, decreased body mass index, manual occupation (not including vibration tool use), and estrogen replacement therapy. 3-6 Cigarette smoking and alcohol consumption are still of unclear significance when concerning the prevalence of primary RP. 7 Secondary RP associated with a known disease, mainly with systemic sclerosis (SSc) (>80% of patients) or other connective tissue diseases (CTDs), is rare and accounts for 10% to 20% of all RP cases. 8 Other common causes of secondary RP include diseases of arteries in the upper limbs (60% of RP occurring in individuals older than 60 years), malignancies, endocrine diseases, occupational syndromes, hematologic disorders, and infections (TABLE 1). 8,9 In addition, several Introduction Raynaud phenomenon (RP) is defined as recurrent, reversible episodes of vasospasm involving peripheral small vessels of the fingers and toes, at times also of the other acral sites (nose, ears, oral mucosa, lips, or nipples), when exposed to a cold environment or stressful situation. 1 This is characterized by a series of color changes in the affected area: first white (lack of blood flow), then bluish (deoxygenation of remaining blood), and red (reperfusion). Attacks can cause distal pain, burning, numbness, and paresthesia. 2 Regarding its etiology, RP is classified as primary (idiopathic) or secondary. Primary RP, which is an isolated finding without an underlying pathology, is common, occurring in about 5% of the general population living in areas with cold climates. 3 The prevalence of RP is higher in women (female-to-male ratio of 9 to 1). There is an associated genetic predisposition: one polymorphic variant was identified within the nitric

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Handy Hints About Raynaud's Phenomenon in Children: A Critical Review

Cited by 8 publications

References 36 publications

Incidental finding of intrathoracic caudate lobe of the liver associated with an arterovenous malformation

Incidental finding of intrathoracic caudate lobe of the liver associated with an arterovenous malformation

Evaluation of Primary and Secondary Raynaud’s Phenomenon in Childhood

Recent advances in the workup and management of Raynaud’s phenomenon

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