Handheld Spectral Domain Optical Coherence Tomography Imaging Through the Undilated Pupil in Infants Born Preterm or With Hypoxic Injury or Hydrocephalus

Tran-Viet, Du; Wong, Brittany; Mangalesh, Shwetha; Maldonado, Ramiro S.; Cotten, C. Michael; Toth, Cynthia A.

doi:10.1097/iae.0000000000001735

Cited by 24 publications

(15 citation statements)

References 28 publications

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“…Our data demonstrated interindividual variability in retinal injury after exposure to HI. This is in line with previous reports that demonstrated exposure to HI conditions resulted in various levels of injuries (mild, moderate and severe) in different individuals including human, rat and mouse neonatal retinas 54 , 59 , 63 , 69 , 70 and brains 56 – 58 , 64 . The exact reasons for these interindividual variabilities in HI-induced injuries are not completely understood.…”

Section: Discussionsupporting

confidence: 93%

Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina

Zaitoun

Shahi

Suscha

et al. 2021

Sci Rep

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Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect the susceptibility of and outcome after ischemic stroke. Although we recently reported that exposure of neonatal mice to hypoxia–ischemia (HI) severely compromises the integrity of the retinal neurovasculature, it is not known whether juvenile mice are similarly impacted. Here we examined the effect of HI injury in juvenile mice on retinal structure and function, in particular the susceptibility of retinal neurons and blood vessels to HI damage. Our studies demonstrated that the retina suffered from functional and structural injuries, including reduced b-wave, thinning of the inner retinal layers, macroglial remodeling, and deterioration of the vasculature. The degeneration of the retinal vasculature associated with HI resulted in a significant decrease in the numbers of pericytes and endothelial cells as well as an increase in capillary loss. Taken together, these findings suggest a need for juveniles suffering from ischemic stroke to be monitored for changes in retinal functional and structural integrity. Thus, there is an emergent need for developing therapeutic approaches to prevent and reverse retinal neurovascular dysfunction with exposure to ischemic stroke.

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Section: Discussionsupporting

confidence: 93%

Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina

Zaitoun

Shahi

Suscha

et al. 2021

Sci Rep

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“…Tran-Viet et al 35 recently found good feasibility for undilated handheld OCT examination using the Envisu C2300 in preterm infants and children with neurologic abnormalities; however, their study did not feature any children with craniosynostosis. Dilation may make it easier to identify the optic nerve or fovea when acquiring handheld OCT images.…”

Section: Research In Contextmentioning

confidence: 93%

Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis

Rufai

Bowman

Bunce

et al. 2021

Trans. Vis. Sci. Tech.

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To determine whether handheld optical coherence tomography (OCT) is feasible and repeatable in children with craniosynostosis.Methods: This was a prospective cross-sectional study. Children with syndromic and non-syndromic craniosynostosis 0 to 18 years of age were recruited between February 13, 2020, and October 1, 2020. Main outcome measures included feasibility (patient recruitment and handheld OCT success rates) and repeatability, which were assessed using intraclass correlation coefficients (ICCs) where repeated images of the optic nerve head (ONH) within the same visit were available. ONH parameters used for repeatability analysis included cup depth, width, and area; disc width; rim height; retinal thickness; retinal nerve fiber layer thickness; and Bruch's membrane opening minimum rim width.Results: Fifty children were approached, and all 50 (100%) were successfully recruited. Median age was 51.1 months (range, 1.9-156.9; interquartile range, 37.0-74.2), and 33 of the children (66%) were male. At least one ONH image was obtained in 43 children (86%), and bilateral ONH imaging was successful in 38 children (76%). Factors boosting the likelihood of success included good understanding and cooperation of the child and parent/guardian and availability of an assistant. Repeatability analysis was performed in 20 children, demonstrating good repeatability (ICC range, 0.77-0.99; the majority exceeded 0.90). OCT correctly identified two cases of intracranial hypertension, one of which was undetected by prior fundoscopy. Conclusions:Handheld OCT is feasible and repeatable in children with syndromic and non-syndromic forms of craniosynostosis.Translational Relevance: Our handheld OCT approach could be used for the clinical surveillance of children with craniosynostosis.

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“…Seven studies 22 31 32 37 38 41 43 included children with other pathology associated with IH, including hydrocephalus 22 37 38 (n=16), papilloedema of unspecified aetiology 32 (n=5), acute lymphoblastic leukaemia 41 (n=1), aseptic meningitis 43 (n=1), growth hormone replacement therapy 31 (n=1), head injury 43 (n=1), recurrent nephrotic syndrome 31 (n=1), rickets 41 (n=1), sagittal sinus thrombosis 43 (n=3) and sigmoid sinus thrombosis 43 (n=1). Of note, Tran-Viet et al 38 used the Envisu handheld OCT system (C2200 and C2300, Bioptigen, Research Triangle Park, North Carolina, USA), with which they successfully scanned 25 out of 26 (96%) undilated eyes of conscious infants without sedation. Other OCT devices used were the Spectralis and DRI-OCT-1 Atlantis; Malem et al 43 did not specify which device was used.…”

Section: Resultsmentioning

confidence: 99%

Detection of intracranial hypertension in children using optical coherence tomography: a systematic review

et al. 2021

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ObjectivesTo evaluate the diagnostic capability of optical coherence tomography (OCT) in children aged under 18 years old with intracranial hypertension (IH).DesignSystematic review.MethodsWe conducted a systematic review using the following platforms to search the keywords ‘optical coherence tomography’ and ‘intracranial hypertension’ from inception to 2 April 2020: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed and Web of Science, without language restrictions. Our search returned 2729 records, screened by two independent screeners. Studies were graded according to the Oxford Centre for Evidence-Based Medicine and National Institutes of Health Quality Assessment Tool for observational studies.ResultsTwenty-one studies were included. Conditions included craniosynostosis (n=354 patients), idiopathic IH (IIH; n=102), space-occupying lesion (SOL; n=42) and other pathology (n=29). OCT measures included optic nerve parameters, rim parameters (notably retinal nerve fibre layer thickness) and retinal parameters. Levels of evidence included 2b (n=13 studies), 3b (n=4) and 4 (n=4). Quality of 10 studies was fair and 11 poor. There was inconsistency in OCT parameters and reference measures studied, although OCT did demonstrate good diagnostic capability for IH in craniosynostosis, IIH and SOL.ConclusionsThis systematic review identified various studies involving OCT to assist diagnosis and management of IH in children with craniosynostosis, IIH, SOL and other pathology, in conjunction with established clinical measures of intracranial pressure. However, no level 1 evidence was identified. Validating prospective studies are, therefore, required to determine optimal OCT parameters in this role and to develop formal clinical guidelines.PROSPERO registration numberCRD42019154254.

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Handheld Spectral Domain Optical Coherence Tomography Imaging Through the Undilated Pupil in Infants Born Preterm or With Hypoxic Injury or Hydrocephalus

Cited by 24 publications

References 28 publications

Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina

Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina

Feasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis

Detection of intracranial hypertension in children using optical coherence tomography: a systematic review

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