Handheld Reflectance Confocal Microscopy for the Diagnosis of Conjunctival Tumors

Cinotti, Élisa; Perrot, Jean‐Luc; Labeille, B.; Campolmi, N; Espinasse, M; Grivet, D.; Thuret, Gilles; Gain, Philippe; Douchet, C.; Andrea, Caroline; Haouas, Maher; Cambazard, F.

doi:10.1016/j.ajo.2014.10.031

Cited by 28 publications

(22 citation statements)

References 24 publications

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“…While this indicates that IVCM cannot replace histology as the gold standard of diagnosis, it does suggest that the need for excisional biopsy can be guided by IVCM findings. Similar results have also been found using a handheld dermatologic confocal device in place of the floor-mounted ophthalmic devices, which allows for easier alignment with the region of interest, including more difficult to image locations such as the caruncle 48 .…”

Section: Conjunctival Melanomasupporting

confidence: 75%

“…The first demonstration, in 2008, of IVCM for CL showed small, hyper-reflective, tightly-packed cells in nests or cyst-like spaces 66 . Cellular atypia, to differentiate these cells from those seen in inflammatory conditions, however, cannot be identified 48 . IVCM may therefore be helpful in differentiating CL from other malignant tumors, but given its similarity in appearance to inflammatory lesions, cannot supplant histology for a definitive diagnosis.…”

Section: Conjunctival Lymphomamentioning

confidence: 99%

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Updates in Ocular Surface Tumor Diagnostics

Nanji¹,

Mercado²,

Dubovy³

et al. 2017

International Ophthalmology Clinics

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Purpose To evaluate technologies and techniques available for the diagnosis of ocular surface tumors. Methods A review of the literature from 1947 to 2017, through the PubMed Database, was conducted in order to evaluate current diagnostic methods for ocular surface tumors. Results Ocular surface squamous neoplasia, conjunctival melanoma, and conjunctival lymphoma are the three most common ocular surface malignancies. Technologies available to assist with diagnosis of these conditions, in addition to full thickness biopsy, include vital dyes, aspiration and impression cytology, in vivo confocal microscopy, ultrasound biomicroscopy, genetic testing, and anterior segment optical coherence tomography. Conclusions Histology remains the gold standard for diagnosis for all 3 of these malignancies. However, multiple diagnostic techniques are available to assist in making preliminary and early diagnoses, in differentiating between similar-appearing lesions, and in some cases, avoiding biopsy prior to initiating treatment. As imaging and technology continue to evolve, these adjunctive techniques will likely continue to play a greater role in clinical practice.

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Section: Conjunctival Melanomasupporting

confidence: 75%

Section: Conjunctival Lymphomamentioning

confidence: 99%

Updates in Ocular Surface Tumor Diagnostics

Nanji¹,

Mercado²,

Dubovy³

et al. 2017

International Ophthalmology Clinics

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“…There are two commercially available CLE systems used to detect neoplasia in patients with BE: endoscope‐based CLE (eCLE) (Pentax Medical Corporation, Tokyo, Japan) and probe‐based CLE (pCLE) (Mauna Kea Technologies, Paris, France) . Several studies have demonstrated the promising utility of CLE in the diagnosis of colorectal, skin, and oral cancer, and in conjunctival tumors and gastrointestinal dysplasia . The initial study of patients with BE showed that CLE had a sensitivity of 92.9% and specificity of 98.4% in predicting neoplasia compared with histological diagnosis .…”

Section: Introductionmentioning

confidence: 99%

“…14 Several studies have demonstrated the promising utility of CLE in the diagnosis of colorectal, skin, and oral cancer, and in conjunctival tumors and gastrointestinal dysplasia. 13,[15][16][17][18] The initial study of patients with BE showed that CLE had a sensitivity of 92.9% and specificity of 98.4% in predicting neoplasia compared with histological diagnosis. 19 However, this high level of accuracy was not borne out by several other reports.…”

Section: Introductionmentioning

confidence: 99%

A meta‐analysis of confocal laser endomicroscopy for the detection of neoplasia in patients with Barrett's esophagus

Xiong

Zhou

et al. 2016

J of Gastro and Hepatol

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“…melanoma). [3][4][5][6][7] In vivo reflectance confocal microscopy (IVCM) is a noninvasive examination tool, routinely used in dermatology. As the resolution is almost as high as in conventional microscopy, confocal microscopy is also referred to as 'virtual biopsy'; especially, melanocytes are remarkably well visualized as melanin is a strong source of contrast in image generation.…”

mentioning

confidence: 99%