Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study

Wang, Hongmei; Liu, Mingyue; Chi, Vu Thi Quynh; Wang, Jing; Zhang, Qing; Liu, Li; Meng, Guang; Yao, Zhanxin; Bao, Xue; Gu, Yeqing; Zhang, Shunming; Sun, Shaomei; Zhou, Ming; Jia, Qiyu; Song, Kun; Huang, Jinlong; Huo, Junsheng; Zhang, Bing; Ding, Gangqiang; Niu, Kaijun

doi:10.1016/j.metabol.2019.01.011

Cited by 46 publications

(53 citation statements)

References 40 publications

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“…Considering the confounding effect of body weight in regards to muscle strength, we calculated the relative HGS by dividing the HGS by body weight in order to normalise the indicator. [17][18][19][20] Anthropometric characteristics, including height, weight and waist circumference (WC), were measured using standardised protocols with the individuals wearing light clothing and no footwear. WC was measured at the midpoint between the last rib cage and iliac crest.…”

Section: Data Collectionmentioning

confidence: 99%

Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study

Shen

et al. 2020

BMJ Open

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ObjectivesA lower relative handgrip strength (HGS) may disrupt metabolic homeostasis and then lead to metabolic syndrome (MetS). There is a paucity of longitudinal studies to examine whether relative HGS at baseline is linked to incident MetS. Thus, the purpose of the present study was to explore the association between relative HGS and new-onset MetS.DesignThis is an observational and longitudinal research.A nationally representative sample of population in China.ParticipantsA total of 3350 subjects without MetS were selected for analysis in the present study. Data are from the China Health and Retirement Longitudinal Study (2011–2015).Outcome measuresWe calculated the relative HGS by dividing the HGS by body weight. Participants were divided into gender-specific quartiles. We estimated HRs for MetS and its components using Cox proportional hazard models according to the relative HGS categories.ResultsAfter multiple adjustment, the risk of MetS increased with the lower quartile of relative HGS in both sexes. Using the highest quartile (Q4) as a reference, the HR for quartile Q3–1 was 1.49 (0.95, 2.34), 1.67 (1.08, 2.59) and 1.76 (1.12, 2.78), respectively, in men, and 1.14 (0.82, 1.58), 1.30 (1.02, 1.57) and 1.28 (1.03, 1.55), respectively, in women. Additionally, we observed that relative HGS was negatively or inversely associated with the risk of abdominal obesity in both sexes.ConclusionsThe current study demonstrated that relative HGS was inversely and independently associated with an increased risk of MetS and abdominal obesity, suggesting a possible role of relative HGS as a useful and simple index for muscle strength in the prediction of occurrence of MetS.

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Section: Data Collectionmentioning

confidence: 99%

Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study

Shen

et al. 2020

BMJ Open

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“…In addition of being a proxy for muscular strength, HGS and RHGS has been proposed as a tool sensitive for use in patients with neuromuscular disorders [13], and for identifying cardiometabolic health [14], including the metabolic syndrome [15], and sarcopenia in the elderly [16][17][18]. Sarcopenia, the loss of muscle mass and function, and dynapenia, low muscle mass and power, have been most frequently associated with old age; however, recent research has shown that even children are at risk [19], due to the current epidemic of sedentary lifestyles [20,21].…”

Section: Introductionmentioning

confidence: 99%

Relative handgrip strength, nutritional status and abdominal obesity in Chilean adolescents

2020

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Handgrip strength (HGS) is a well-established indicator of muscle strength and can help to identify risk of sarcopenic obesity in children. This study explores the relationship between adiposity and muscular strength in healthy Chilean adolescents. Adolescents (n = 491) aged 10-17 were selected from five schools in Santiago, Chile. HGS was determined by dynamometry. Anthropometry (weight, height, waist and mid arm circumference), physical activity and socioeconomic status were also measured. Relative HGS (RHGS) was calculated by dividing maximum HGS of the dominant hand by body-mass index (BMI) and low RHGS was categorized as <25 th percentile by sex. Logistic regression was used to determine the relationship between two markers of adiposity (abdominal obesity category by waist circumference and nutritional status measured by BMI category) and low RHGS, adjusting for possible confounding variables. Participants were on average 13.6y (2.4), 32.8% were overweight or obese and 37.5% were at risk of or had abdominal obesity. RHGS was 1.25 kg/kg/m 2 overall, with a significant difference by sex (1.51 for boys versus 1.14 for girls). In adjusted analyses, boys and girls with risk of abdominal obesity, had 3.3 (1.6-6.6) and 4.1 (1.8-9.3) increased odds of low RHGS, respectively, compared to boys and girls with normal waist circumference. Those with abdominal obesity compared to normal WC, had 8.5 (3.4-21.4) and 6.5 (2.0-21.3) increased odds of low RHGS for boys and girls, respectively. We observed similar associations for BMI category. In our sample of healthy adolescents, higher adiposity related to greater odds of low muscle strength measured by dynamometry. Considering the demographic shift from a young to an aging population in many countries, along with the increasing prevalence of obesity beginning in childhood, understanding how adiposity relates to low muscle strength is of growing importance.

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“…Our finding is consistent with a recent large-scale study that surveyed 17,703 people older than 40 years. 10 Wu et al revealed an inverse association between hand grip strength and MetS as well as its separated components. 10 The association remained significant after adjustment for sociodemographic variables, lifestyle factors, total energy intake, and family history of disease.…”

Section: Discussionmentioning

confidence: 99%

“…10 Wu et al revealed an inverse association between hand grip strength and MetS as well as its separated components. 10 The association remained significant after adjustment for sociodemographic variables, lifestyle factors, total energy intake, and family history of disease. A proposed mechanism is that neuroendocrine dysfunction affects skeletal muscles in patients with MetS, which leads to a decrease in strength and insulin metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…4 Furthermore, several recent studies demonstrated an inverse association between handgrip strength and prevalence of MetS. [10][11][12] The negative association between handgrip strength and MetS may be mediated by insulin resistance, which leads to impairment of skeletal muscle glycogen synthesis. 13 In addition, patients with MetS tend to have an elevated level of inflammatory markers, such as interleukin-6 and tumor necrosis factor-α, which also cause muscle dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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<p>Association between metabolic syndrome and limb muscle quantity and quality in older adults: a pilot ultrasound study</p>

Chang¹,

Yang²,

Wu³

et al. 2019

DMSO

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Purpose: Limited imaging studies have investigated whether limb muscle quantity and quality change after metabolic syndrome (MetS) development. This pilot study examined MetS influence on limb muscle characteristics in older adults. Methods: Participants were recruited from annual health examinations; their right biceps brachii, triceps brachii, rectus femoris, and gastrocnemius muscles were measured by ultrasound. Anthropometric parameters, blood biochemistry, and physical performance (handgrip strength and gait speed) were also examined. Results: Overall, 129 participants were enrolled, including 26 with MetS. Although handgrip strength was lower in MetS patients, there were no significant between-group differences considering thickness and mean echogenicity of the four muscles. Handgrip strength was positively correlated with the thickness of biceps brachii, triceps brachii, and rectus femoris but was negatively associated with their echogenicity. On multivariate analysis, triceps muscle echogenicity was trivially associated (odds ratio, 0.93; 95% confidence interval, 0.86-0.99) with MetS, possibly due to multicollinearity with grip strength. Conclusion: No significant difference was recognized in limb muscle thickness and echogenicity in the geriatric population with MetS compared with healthy controls by ultrasound imaging. However, the finding might be caused by the small sample size of our participants. Future largescale studies should explore the influence of separated risk factors of MetS on limb muscle echotexture and examine whether manifestation differs in different age populations.

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Handgrip strength is inversely associated with metabolic syndrome and its separate components in middle aged and older adults: a large-scale population-based study

Cited by 46 publications

References 40 publications

Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study

Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study

Relative handgrip strength, nutritional status and abdominal obesity in Chilean adolescents

<p>Association between metabolic syndrome and limb muscle quantity and quality in older adults: a pilot ultrasound study</p>

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