Handgrip Strength as a Reflection of General Muscle Strength in Chronic Obstructive Pulmonary Disease

Fonseca, Jéssica; Machado, Felipe; Santin, Lais; Andrello, Ana Carolina; Schneider, Lorena Paltanin; Belo, Letícia Fernandes; Rodrigues, Antenor; Rugila, Diery Fernandes; Furlanetto, Karina Couto; Hernandes, Nídia A.; Pitta, Fábio

doi:10.1080/15412555.2021.1919608

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…Several studies have shown that handgrip strength reflects general muscle strength and sarcopenia [ 15 , 16 ], but a large, well-powered GWAS of resistance exercise training does not exist. Thus, we hypothesized that genes that respond well to resistance training could overlap those associated with handgrip strength.…”

Section: Resultsmentioning

confidence: 99%

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Gautvik

Olstad

Raue

et al. 2022

Eur Rev Aging Phys Act

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Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays. Three age groups, similarly trained, were compared: younger adults (age 24 ± 4 years), older adults of average age 70 years (Oslo cohort) and above 80 years (old BSU cohort). To increase statistical strength, one of the older cohorts was used for validation. Ingenuity Pathway analysis (IPA) was used to identify predicted biological effects of a gene set that changed expression after exercise, and Principal Component Analysis (PCA) was used to visualize differences in muscle gene expressen between cohorts and individual participants as well as overall changes upon exercise. Results Younger adults, showed few transcriptome changes, but a marked, significant impact was observed in persons of average age 70 years and even more so in persons above 80 years. The 249 transcripts positively or negatively altered in both cohorts of older adults (q-value < 0.1) were submitted to gene set enrichment analysis using IPA. The transcripts predicted increase in several aspects of “vascularization and muscle contractions”, whereas functions associated with negative health effects were reduced, e.g., “Glucose metabolism disorder” and “Disorder of blood pressure”. Several genes that changed expression after intervention were confirmed at the genome level by containing single nucleotide variants associated with handgrip strength and muscle expression levels, e.g., CYP4B1 (p = 9.2E-20), NOTCH4 (p = 9.7E-8), and FZD4 (p = 5.3E-7). PCA of the 249 genes indicated a differential pattern of muscle gene expression in young and elderly. However, after exercise the expression patterns in both young and old BSU cohorts were changed in the same direction for the vast majority of participants. Conclusions The positive impact of heavy-load strength training on the transcriptome increased markedly with age. The identified molecular changes translate to improved vascularization and muscular strength, suggesting highly beneficial health effects for older adults.

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Section: Resultsmentioning

confidence: 99%

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Gautvik

Olstad

Raue

et al. 2022

Eur Rev Aging Phys Act

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“…Dessa forma, torna-se evidente que indivíduos com pontuações mais altas, indicativas de um maior risco de sarcopenia, apresentaram menor força muscular. Esses resultados fortalecem a posição da FPP como um indicador de força muscular 27 nesta amostra, ao mesmo tempo que sustentam a hipótese de que o SARC-F pode ser um reflexo da força e função muscular 28 .…”

Section: Discussionunclassified

Risco de Sarcopenia e Toxicidade Gastrointestinal de Pacientes Idosos em Quimioterapia

Silva,

Cavalcante,

Almeida

et al. 2024

Rev. Bras. Cancerol.

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Introdução: A sarcopenia é uma condição associada ao mau prognóstico, incluindo o risco para pior toxicidade gastrointestinal em pacientes com câncer submetidos a tratamento quimioterápico. Objetivo: avaliar a associação entre o risco de sarcopenia e a toxicidade gastrointestinal de pacientes idosos em quimioterapia. Método: Estudo observacional com coleta transversal, envolvendo 60 idosos diagnosticados com tumores sólidos, selecionados por conveniência, em regime de quimioterapia exclusiva ou combinada. O risco de sarcopenia foi avaliado por meio dos questionários SARC-F e SARC-CalF. O diagnóstico de desnutrição foi avaliado pela mini avaliação nutricional reduzida (MAN-r). Resultados: Entre os pacientes incluídos, o risco de sarcopenia (SARC-F) foi observado em 15%. Ao utilizar o SARC-CalF, esse número cresceu para 33,3%. Foi observado que uma maior pontuação do SARC-F esteve independentemente associada ao maior número de sintomas relativos à toxicidade gastrointestinal. Além disso, maiores escores do SARC-F (mais risco) se associaram à menor força de preensão palmar e aos menores escores da MAN-r. Elevados escores do SARC-CalF se associaram à menor força de preensão palmar e menores escores na MAN-r. Conclusão: Os achados sugerem que o SARC-F pode ser uma ferramenta guia para intervenções relacionadas à melhora do estado muscular, potencialmente prevenindo o elevado número de sintomas relacionados à quimiotoxicidade gastrointestinal.

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“…In particular, both Imperial College London and the University of Toronto started early and have obtained some high-quality scientific clinical outcomes, including breathlessness rehabilitation ( Man et al, 2016 ) and outcome measures combined ET ( Jones et al, 2019 ), and the effects of post-rehabilitation exercise based on community ( Butler et al, 2020 ). The researchers also explored the pulmonary protection mechanisms of COPD-related quadriceps muscle dysfunction, including sex differences ( Sharanya et al, 2019 ), utilization of non-invasive imaging tools ( Rozenberg et al, 2017 ), handgrip strength reflection ( Fonseca et al, 2021 ), the clustering physiological responses to arm activity ( Lima et al, 2016 ), and the physical activity during moderate (out-patient managed) ( Alahmari et al, 2016 ). Monash University and the University of Bern studied the effects of peripheral muscle training ( Bisca et al, 2017 ), the WBV intervention ( Furness et al, 2012 ), and physical activity significantly correlated with quadriceps strength ( Osthoff et al, 2013 ) on skeletal muscle dysfunction, exercise tolerance and functional performance.…”

Section: Discussionmentioning

confidence: 99%

Mapping the global research landscape and hotspot of exercise therapy and chronic obstructive pulmonary disease: A bibliometric study based on the web of science database from 2011 to 2020

Zhou

Liu

2022

Front. Physiol.

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Background: The application of exercise therapy (ET) in chronic obstructive pulmonary disease (COPD) is generating increasing clinical efficacy and social-economic value. In this study, research trends, evolutionary processes and hot topics in this field are detailed, as well as predictions of future development directions.Methods: Search for literature in the field of COPD and ET and analyze data to generate knowledge graphs using VOSiewer and CiteSpace software. The time frame for the search was from 2011 to January 2021. Then we extracted full-text key information (such as title, journal category, publication date, author, country and institution, abstract, and keyword) and obtained the co-citation analysis. Use hierarchal clustering analysis software developed by VOSviewer to map common citations, and use Citespace software to plot trend networks.Results: The United States topped the list with 27.91% of the number of articles posted, followed by the UK at 25.44%. Imperial College London was the highest number of article publications in institutions, followed by Maastricht University and the University of Toronto. The Royal Brompton Harefield NHS Foundation Trust was one of many research institutions and currently holds the highest average citations per item (ACI) value, followed by Imperial College London and the University of Leuven. Judging from the number of publications related to ET and COPD, it is mainly published in cell biology, respiratory pulmonary diseases, and rehabilitation experiments study medicine. The European Respiration Journal is the most widely published in this field, followed by the International Journal of Chronic Obstructive Pulmonary Disease and Respiratory Medicine.Conclusion: COPD combined with ET is widely used in clinical practice and is on the rise. A distinctive feature of the field is multidisciplinary integration. Rehabilitation research for COPD involves multidisciplinary collaboration, tissue engineering, and molecular biology mechanism studies to help patients remodel healthy breathing. Multidisciplinary rehabilitation measures provide a solid foundation for advancing clinical efficacy in the field of COPD.

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Handgrip Strength as a Reflection of General Muscle Strength in Chronic Obstructive Pulmonary Disease

Cited by 9 publications

References 31 publications

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Risco de Sarcopenia e Toxicidade Gastrointestinal de Pacientes Idosos em Quimioterapia

Mapping the global research landscape and hotspot of exercise therapy and chronic obstructive pulmonary disease: A bibliometric study based on the web of science database from 2011 to 2020

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