Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study

Veni, T.; Boyas, Sébastien; Beaune, Bruno; Bourgeois, H.; Rahmani, Abderrahmane; Bochereau, A.; Durand, Sylvain; Morel, Baptiste

doi:10.1007/s00520-018-4320-0

Cited by 25 publications

(30 citation statements)

References 63 publications

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“…Theoretically, once this stable state is reached, it can be maintained indefinitely. The mean relative force asymptotes measured in the present study (FFs, 42.4% of MVC; PFs, 43.0% of MVC; not statistically different) are similar to those reported in previous studies for FFs (40.3% of MVC; Veni et al., 2018) and PFs (40.9% of MVC; Abdalla et al., 2018). Although these data are similar, it is important to note the high inter‐individual variability (range, ∼20–70% of MVC for both muscle groups).…”

Section: Discussionsupporting

confidence: 92%

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Chartogne

Rahmani

Nicolon

et al. 2020

Experimental Physiology

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Neuromuscular fatigability is commonly attributed to central and peripheral origins. However, there is strong evidence of interactions between these two mechanisms. According to the idea that peripheral fatigability might be centrally regulated, one can hypothesize that neuromuscular fatigability would be correlated between different muscle groups at the individual level. Thirty-two healthy participants (16 women and 16 men) completed two 5 min fatiguing exercises [60 isometric maximal voluntary contractions (MVCs)] with finger flexors (FFs) and ankle plantar flexors (PFs) in two randomized sessions. Neuromuscular testing was conducted before, during (every six MVCs) and directly after the fatigue procedure. The force asymptote (F A) was calculated as the asymptote of the forcetime relationship. Changes (post-vs. pre-fatigue) in the exercise-evoked force (ΔDb 100), voluntary activation (ΔVA) and central activation ratio (∆CAR) were also investigated.

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Section: Discussionsupporting

confidence: 92%

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Chartogne

Rahmani

Nicolon

et al. 2020

Experimental Physiology

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“…Although a recent pilot study suggested that CRF could be measured more objectively from mechanical parameters of hand muscles (Veni et al., 2018), it nevertheless remains a subjective symptom that is essentially assessed by the patients themselves. A number of studies and dedicated guidelines have highlighted measures for improving under‐recognition and under‐treatment of CRF with a double objective: first, to improve healthcare professionals’ knowledge of assessment techniques and potential interventions.…”

Section: Discussionmentioning

confidence: 99%

Patient perspectives on supportive care in cancer: Results of the Calista 2 study

Simon¹,

Ganem

Touboul³

et al. 2020

Eur J Cancer Care

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Over recent decades, the management of cancer patients has improved as a result of earlier diagnosis, better management of side effects, and more effective therapies. The question of patient quality of life-both during and following cancer treatment-consequently requires greater attention than has previously been the case, with supportive and palliative care playing a particularly important role. Dedicated clinical practice guidelines are regularly updated to improve of the management of a variety of issues, both during and after the active disease stage. Patient-reported outcome measures have emerged as an important aspect of improving quality of life in a period of patient-centred

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“…Likely due at least in part to the more rapid decline in neuromuscular capacity, the time-to-task-failure during the cycling task was 18% shorter in fatigued compared with non-fatigued participants. Using isometric exercise tasks, previous studies have similarly demonstrated that those with CRF reach task failure during sustained contractions more quickly than controls 18 47 48 and that fatigability during isometric tasks is associated with CRF severity 49 . However, the present study improves on previous designs by utilising a more ecologically valid exercise-mode to assess performance fatigability, as well as gold-standard assessments of neuromuscular function.…”

Section: Performance Fatigabilitymentioning

confidence: 93%

Physiological and psychosocial correlates of cancer related fatigue

Brownstein

Twomey

Temesi

et al. 2020

Preprint

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Cancer-related fatigue (CRF) is a common and distressing symptom of cancer and its treatments that may persist for years following treatment completion in approximately one-third of cancer survivors. Despite its high prevalence, little is known about the pathophysiology of CRF. Using a comprehensive group of physiological and psychosocial variables, the aim of the present study was to identify correlates of CRF in a heterogenous group of cancer survivors. Ninety-three cancer survivors (51 fatigued, 42 non-fatigued, with grouping based on validated cut-off scores derived from The Functional Assessment of Chronic Illness Therapy - Fatigue scale) completed assessments of performance fatigability (i.e. the change in maximal force-generating capacity, contractile function and capacity of the central nervous system to activate muscles caused by cycling exercise), cardiopulmonary exercise testing, venous blood samples for whole blood cell count and inflammatory markers and body composition. Participants also completed questionnaires measuring demographic, treatment-related, and psychosocial variables. The results showed that performance fatigability (decline in muscle strength during exercise), time-to-task-failure, peak oxygen uptake (V̇O2peak), tumor necrosis factor-α (TNF-α), body fat percentage and lean mass index were associated with CRF severity. Performance fatigability, V̇O2peak, TNF-α and age explained 35% of the variance in CRF severity. Furthermore, those with clinically-relevant CRF reported more pain, more depressive symptoms, less social support, and were less physically active than non-fatigued cancer survivors. Given the association between CRF and numerous physical activity related measures, including performance fatigability, cardiorespiratory fitness, and anthropometric measures, the present study identifies potential biomarkers by which the mechanisms underpinning the effect of physical activity interventions on CRF can be investigated.

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Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study

Abstract: The handgrip maximal force, critical force, and force variability may offer objective measures of the different dimensions of cancer-related fatigue and could provide a complementary approach to the patient reported outcomes.

Cited by 25 publications

References 63 publications

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Neuromuscular fatigability amplitude and aetiology are interrelated across muscles

Patient perspectives on supportive care in cancer: Results of the Calista 2 study

Physiological and psychosocial correlates of cancer related fatigue

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