Handedness patterns in autism suggest subtypes

Soper, Henry V.; Satz, Paul; Orsini, Donna L.; Henry, Rolando R.; Zvi, Jennifer C.; Schulman, Marion

doi:10.1007/bf01531727

Cited by 120 publications

(71 citation statements)

References 24 publications

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“…This prediction held true even after controlling for parental handedness and postnatal maternal anxiety (odds ratio = 1.23, p < 0.05). These results complement findings of more mixed handedness in AD (Soper et al, 1986).…”

Section: Prenatal Stress Can Cause Behaviors Similar To Key Symptoms supporting

confidence: 61%

Prenatal stress and risk for autism

Kinney

Münir

Crowley

et al. 2008

Neuroscience & Biobehavioral Reviews

368

251

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This paper reviews several converging lines of research that suggest that prenatal exposure to environmental stress may increase risk for Autistic Disorder (AD). We first discuss studies finding that prenatal exposure to stressful life events is associated with significantly increased risk of AD, as well as other disorders, such as schizophrenia and depression. We then review evidence from animal and human studies that prenatal stress can produce both (a) abnormal postnatal behaviors that resemble the defining symptoms of AD, and (b) other abnormalities that have elevated rates in AD, such as learning deficits, seizure disorders, perinatal complications, immunologic and neuroinflammatory anomalies, and low postnatal tolerance for stress. We explain why an etiologic role for prenatal stress is compatible with genetic factors in AD, and describe how stress can disrupt fetal brain development. Finally, we discuss implications for understanding underlying processes in AD, including potential gene-environment interactions, and developing new therapies and early prevention programs.

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Section: Prenatal Stress Can Cause Behaviors Similar To Key Symptoms supporting

confidence: 61%

Prenatal stress and risk for autism

Kinney

Münir

Crowley

et al. 2008

Neuroscience & Biobehavioral Reviews

368

251

View full text Add to dashboard Cite

show abstract

“…[27][28][29][30]. However, other studies involving children, suggests that stronger hand dominance (left or right) correlates with both earlier language acquisition [31] and the successful hemispheric specialization for language [1].…”

Section: Introductionmentioning

confidence: 95%

Handedness as a marker of cerebral lateralization in children with and without autism

Forrester

Pegler

Thomas

et al. 2014

Behavioural Brain Research

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h i g h l i g h t s• We report on a detailed set of hand actions from two populations of right-handed boys.• Typically developing boys demonstrated a right hand bias for actions to objects.• Typically developing boys also demonstrated a left hand bias for actions to the self.• Boys with autism revealed mixed-handedness for actions to objects and to the self.• Handedness reveals a dissociation for functional specialization of the hemispheres. a r t i c l e i n f o b s t r a c tWe employed a multiple case studies approach to investigate lateralization of hand actions in typically and atypically developing children between 4 and 5 years of age. We report on a detailed set of over 1200 hand actions made by four typically developing boys and four boys with autism. Participants were assessed for unimanual hand actions to both objects and the self (self-directed behaviors). Individual and group analyses suggest that typically developing children have a right hand dominance for hand actions to objects and a left hand dominance for hand actions for self-directed behaviors, revealing a possible dissociation for functional specialization of the left and right hemispheres respectively. Children with autism demonstrated mixed-handedness for both target conditions, consistent with the hypothesis that there is reduced cerebral specialization in these children. The findings are consistent with the view that observed lateralized motor action can serve as an indirect behavioral marker for evidence of cerebral lateralization.

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“…However, studies which have used laterality judgements in autism have not necessarily found group differences (David et al, 2010). Previous studies into handedness in ASD have shown that many people with ASD are ambidextrous and may show an ambiguous handedness profile switching arbitrarily between left and right (Cornish and McManus 1996;Soper et al 1986). This could make it more difficult for them to make judgements about laterality due to confusion between left and right.…”

Section: Egocentric Transformations Taskmentioning

confidence: 99%

Spatial Transformations of Bodies and Objects in Adults with Autism Spectrum Disorder

Pearson

Marsh

Hamilton

et al. 2014

J Autism Dev Disord

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Previous research into autism spectrum disorder (ASD) has shown people with autism to be impaired at visual perspective taking. However it is still unclear to what extent the spatial mechanisms underlying this ability contribute to these difficulties. In the current experiment we examine spatial transformations in adults with ASD and typical adults. Participants performed egocentric transformations and mental rotation of bodies and cars. Results indicated that participants with ASD had general perceptual differences impacting on response times across tasks. However, they also showed more specific differences in the egocentric task suggesting particular difficulty with using the self as a reference frame. These findings suggest that impaired perspective taking could be grounded in difficulty with the spatial transformation used to imagine the self in someone else's place. © 2014 Springer Science+Business Media New York

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Handedness patterns in autism suggest subtypes

Cited by 120 publications

References 24 publications

Prenatal stress and risk for autism

Prenatal stress and risk for autism

Handedness as a marker of cerebral lateralization in children with and without autism

Spatial Transformations of Bodies and Objects in Adults with Autism Spectrum Disorder

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