Handbook of Aseptic Processing and Packaging

David, Jairus R. D.; Graves, Ralph H.; Szemplenski, Thomas

doi:10.1201/b13026

Cited by 9 publications

(11 citation statements)

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“…Various approaches are used to control postprocessing contamina tion in food processing plants, including stringent imple mentation of good manufacturing practices, sanitation standard operating procedures, sterile packaging technolo gies (36), in-package postlethality treatments, and reformu lation of products with antimicrobial agents. Use of molecular subtyping approaches to better understand L. monocytogenes ecology and transmission in various foodassociated environments will continue to improve control of L. monocytogenes and prevention of cross-contamination.…”

mentioning

confidence: 99%

Listeria monocytogenes Persistence in Food-Associated Environments: Epidemiology, Strain Characteristics, and Implications for Public Health

Ferreira

Wiedmann

Teixeira

et al. 2014

Journal of Food Protection

594

466

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Over the last 10 to 15 years, increasing evidence suggests that persistence of Listeria monocytogenes in food processing plants for years or even decades is an important factor in the transmission of this foodborne pathogen and the root cause of a number of human listeriosis outbreaks. L. monocytogenes persistence in other food-associated environments (e.g., farms and retail establishments) may also contribute to food contamination and transmission of the pathogen to humans. Although L. monocytogenes persistence is typically identified through isolation of a specific molecular subtype from samples collected in a given environment over time, formal (statistical) criteria for identification of persistence are undefined. Environmental factors (e.g., facilities and equipment that are difficult to clean) have been identified as key contributors to persistence; however, the mechanisms are less well understood. Although some researchers have reported that persistent strains possess specific characteristics that may facilitate persistence (e.g., biofilm formation and better adaptation to stress conditions), other researchers have not found significant differences between persistent and nonpersistent strains in the phenotypic characteristics that might facilitate persistence. This review includes a discussion of our current knowledge concerning some key issues associated with the persistence of L. monocytogenes, with special focus on (i) persistence in food processing plants and other food-associated environments, (ii) persistence in the general environment, (iii) phenotypic and genetic characteristics of persistent strains, (iv) niches, and (v) public health and economic implications of persistence. Although the available data clearly indicate that L. monocytogenes persistence at various stages of the food chain contributes to contamination of finished products, continued efforts to quantitatively integrate data on L. monocytogenes persistence (e.g., meta-analysis or quantitative microbial risk assessment) will be needed to advance our understanding of persistence of this pathogen and its economic and public health impacts.

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mentioning

confidence: 99%

Listeria monocytogenes Persistence in Food-Associated Environments: Epidemiology, Strain Characteristics, and Implications for Public Health

Ferreira

Wiedmann

Teixeira

et al. 2014

Journal of Food Protection

594

466

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“…Additionally, there seems to be a general lack of technical specifi cations for this technology. It is generally felt that much has been left to the expertise and skill of the individual operators (David et al ., 2013). A major challenge facing the form-fi ll-seal units is that they will need to operate at much higher speeds in the future.…”

Section: Current and Future Technical Challengesmentioning

confidence: 99%

“…In the 1940s the Dole aseptic process was developed by McKinley Martin. This process contained four separate operations, namely (1) heat sterilization of the product and subsequent cooling (2) steam sterilization of the containers and lids (3) aseptic fi lling of the cooled product into the sterilized containers, and (4) sealing of the lids in an atmosphere of superheated steam (David et al ., 2013). In the 1960s chlorine was used as the sterilizing agent for aseptic packaging material, but in 1981 the FDA approved the use of hydrogen peroxide as the sterilant.…”

Section: Brief History Of Aseptic Packagingmentioning

confidence: 99%

“…Today, there are well over 500 different aseptic systems for the manufacture of retail packages and bulk containers in the USA, and over two dozen manufacturers of aseptic fi lling equipment worldwide. There are a number of excellent research articles, reviews, book chapters and books covering the different aspects of aseptic packaging (Nelsom, 2010;David et al ., 2013). The focus of this chapter is on the role and potential applications of a sterilizing technology such as electron beam (eBeam) technology in aseptic food packaging, with special focus on the use of this technology for sterilizing packaging materials.…”

Section: Introductionmentioning

confidence: 99%

“…Aseptic food packaging is a specialized form of food packaging where the food and the package are independently processed and sterilized, and then brought together and the food is hermetically sealed within the package under aseptic conditions (David et al ., 2013). Aseptic packaging and fi lling is very common and growing in the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aseptic packaging of foods and its combination with electron beam processing

Pillai

Shayanfar

2015

Electron Beam Pasteurization and Complementary Food Processing Technologies

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Control of surge tanks for continuous manufacturing of monoclonal antibodies

Thakur

Nikita

Tiwari

et al. 2021

Biotech & Bioengineering

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Surge tanks are critical but often overlooked enablers of continuous bioprocessing. They provide multiple benefits including dampening of concentration gradients and allowing process resumption efforts in case of equipment failure or unexpected deviations, which can occur during a continuous campaign of weeks or months. They are also useful in enabling steady‐state operation across a continuous train by facilitating mass balance between unit operations such as chromatography which have periodic loading and elution cycles. In this paper, we propose a design of a system of surge tanks for a monoclonal antibody (mAb) production process consisting of cell culture, clarification, capture chromatography, viral inactivation, polishing chromatography, and single‐pass ultrafiltration and diafiltration. A Python controller has been developed for robust control of the continuous train. The controller has four layers, namely data acquisition, process scheduling, deviation handling, and real‐time execution. A set of general guidelines for surge tank placement and sizing have been proposed together with process control strategies based on the design space of the individual unit operations, failure modes analysis of the different equipment, and expected variability in the process feed streams for both fed‐batch and perfusion bioreactors. The control system has been successfully demonstrated for several continuous runs of up to 36 h in duration and is able to leverage surge tanks for robust control of the continuous train in the face of product variability as well as process errors while maintaining critical quality attributes. The proposed set of strategies for surge tank control are adaptable to most continuous processing setups for mAbs, and together form the first framework that can fully realize the benefits of surge tanks in continuous bioprocessing.

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Handbook of Aseptic Processing and Packaging

Cited by 9 publications

References 0 publications

Listeria monocytogenes Persistence in Food-Associated Environments: Epidemiology, Strain Characteristics, and Implications for Public Health

Listeria monocytogenes Persistence in Food-Associated Environments: Epidemiology, Strain Characteristics, and Implications for Public Health

Aseptic packaging of foods and its combination with electron beam processing

Control of surge tanks for continuous manufacturing of monoclonal antibodies

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