Hand Rejuvenation Using a Combination Approach

Butterwick, Kimberly J.; Sadick, Neil S.

doi:10.1097/dss.0000000000000687

Cited by 31 publications

(30 citation statements)

References 38 publications

(39 reference statements)

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“…Based on the result of neocollagenesis, DLMR01 might be more effective, compared to the pre‐existing fillers, when applied for additional indications, such as hand rejuvenation, striae distensae, scar remodeling, treating minor wrinkles in crow's feet and perioral area, and pore reduction, the pathogeneses of which consist mainly of collagen reduction and degeneration. Aged hands show loss of subcutaneous fat, collagen, and collagen elasticity, making the underlying structures of the bones and veins more visible 21 . Figueiredo enrolled subjects with severe to a very severe loss of fat tissue and markedly visible underlying structures and treated them with PCL dermal fillers 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Aged hands show loss of subcutaneous fat, collagen, and collagen elasticity, making the underlying structures of the bones and veins more visible. 21 Figueiredo enrolled subjects with severe to a very severe loss of fat tissue and markedly visible underlying structures and treated them with PCL dermal fillers. 16 The study showed that PCL fillers could effectively and safely improve the aged hand dorsum.…”

Section: Discussionmentioning

confidence: 99%

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In vivo evaluation of novel particle‐free polycaprolactone fillers for safety, degradation, and neocollagenesis in a rat model

Hong

Kim

Kwon

et al. 2021

Dermatologic Therapy

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Dermal fillers have become popular due to the increased demand for skin rejuvenation products. Polycaprolactone (PCL), a newly developed bioresorbable medical polymer, has emerged as a durable and safe dermal filler. However, available PCL fillers cause irritation; carrier gels can coagulate PCL particles, block the injection needle, and cause nonhomogeneity of particle suspensions that could be responsible for the observed side effects. To relieve pain, premixing PCL filler with lidocaine.However, this formulation changes the property of the CMC portion of the PCL filler, and possibly results in an uneven suspension of the PCL particles. Hence, a particlefree PCL homogeneously solubilized in water was developed to overcome these limitations. This study aimed to assess the in vivo safety, biodegradability, and neocollagenesis ability of a novel PCL filler, DLMR01 using a rat model. Fillers were characterized after injecting a vehicle control or DLMR01 using a digital camera, folliscope, and a three-dimensional profiling system. Biopsy was performed to evaluate biocompatibility and neocollagenesis. Skin elasticity was measured using a Cutometer. DLMR01 caused no needle occlusion by particle aggregation or laborious injectability. Filler nodules dispersed to surrounding tissues within 6 hours without further granuloma formation. Histological inspection revealed no tissue residual material or foreign body reaction during the 12-week test period. DLMR01 increased dermal thickness, collagen regeneration, and skin elasticity. In conclusion, this study demonstrates the potential of DLMR01 for dermal rejuvenation in a rat model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of novel particle‐free polycaprolactone fillers for safety, degradation, and neocollagenesis in a rat model

Hong

Kim

Kwon

et al. 2021

Dermatologic Therapy

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“…20 Initial studies using RF devices have been aimed at skin tightening, with the first monopolar RF device was approved by the FDA for periorbital rhytides in 2002, followed by full face wrinkle in 2004, as well as the temporary improvement in the appearance of cellulite when vibration was added to the delivery system. [8][9][10][11]23 More recently, RF has been used for fat reduction. 24 F I G U R E 1 Pretreatment (left) and 3-weeks post 1.5 ml of calcium hydroxylapatite treatment (right)…”

Section: Radiofrequencymentioning

confidence: 99%

Noninvasive body contouring by dermal fillers, radiofrequency, and focused ultrasound: A review

Alhaddad

Boen

Fabi

et al. 2020

Dermatological Reviews

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There has been a current trend in aesthetic medicine for patients to seek procedures with minimal downtime. To meet this demand, in the past few years, there have been several new energy-based devices in the market to treat unwanted fat noninvasively. Noninvasive body contouring involves almost no epidermal damage and minimal downtime. This review will focus on the use of dermal fillers to improve skin texture abnormalities, radiofrequency, and ultrasound devices for body contouring. Cryolipolysis, a popular body contouring technology, will be addressed in a separate paper by the authors due to a large amount of data on this topic.

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“…Hand rejuvenation has been described through the use of fat, 2–5 fillers, 2,6–8 skin excision, 2,9 resurfacing, 2,10 sclerotherapy, 2,11 and a combination approach. 2,12,13 Recently, the Food and Drug Administration has approved Restylane Lyft as the first hyaluronic filler for hand rejuvenation. Restylane Lyft restores volume to the dorsal hand improving the contour and fullness of the hand (Fig.…”

Section: Introductionmentioning

confidence: 99%