Hand preference and hand skill in children with autism

Cornish, Kim; McManus, I. C.

doi:10.1007/bf02172349

Cited by 87 publications

(71 citation statements)

References 15 publications

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“…These factors limit the generalizability of the results (e.g. to females and individuals who are left handed or lack handedness, which may be more common in autism (Cornish & McManus, 1996)) and suggest that replication with a more diverse sample is required. Finally, given recent work demonstrating that neural activation is related to how individuals visually scan face stimuli (Dalton et al, 2005), it is possible that our results may in part reflect abnormal visual face scanning in the clinical groups.…”

Section: Discussionmentioning

confidence: 99%

Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders

Pinkham

Hopfinger

Pelphrey

et al. 2008

Schizophrenia Research

340

279

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Schizophrenia and autism both feature significant impairments in social cognition and social functioning, but the specificity and mechanisms of these deficits remain unknown. Recent research suggests that social cognitive deficits in both disorders may arise from dysfunctions in the neural systems that underlie social cognition. We explored the neural activation of discrete brain regions implicated in social cognitive and face processing in schizophrenia subgroups and autism spectrum disorders during complex social judgments of faces. Twelve individuals with autism spectrum disorders (ASD), 12 paranoid individuals with schizophrenia (P-SCZ), 12 non-paranoid individuals with schizophrenia (NP-SCZ), and 12 non-clinical healthy controls participated in this cross sectional study. Neural activation, as indexed by blood oxygenation level dependent (BOLD) contrast, was measured in a priori regions of interest while individuals rated faces for trustworthiness. All groups showed significant activation of a social cognitive network including the amygdala, fusiform face area (FFA), superior temporal sulcus (STS), and ventrolateral prefrontal cortex (VLPFC) while completing a task of complex social cognition (i.e. trustworthiness judgments). ASD and P-SCZ individuals showed significantly reduced neural activation in the right amygdala, FFA, and left VLPFC as compared to controls and in the left VLPFC as compared to NP-SCZ individuals during this task. These findings lend support to models hypothesizing well-defined neural substrates of social cognition and suggest a specific neural mechanism that may underlie social cognitive impairments in both autism and paranoid schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders

Pinkham

Hopfinger

Pelphrey

et al. 2008

Schizophrenia Research

340

279

View full text Add to dashboard Cite

show abstract

“…However, studies which have used laterality judgements in autism have not necessarily found group differences (David et al, 2010). Previous studies into handedness in ASD have shown that many people with ASD are ambidextrous and may show an ambiguous handedness profile switching arbitrarily between left and right (Cornish and McManus 1996;Soper et al 1986). This could make it more difficult for them to make judgements about laterality due to confusion between left and right.…”

Section: Egocentric Transformations Taskmentioning

confidence: 99%

Spatial Transformations of Bodies and Objects in Adults with Autism Spectrum Disorder

Pearson

Marsh

Hamilton

et al. 2014

J Autism Dev Disord

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Previous research into autism spectrum disorder (ASD) has shown people with autism to be impaired at visual perspective taking. However it is still unclear to what extent the spatial mechanisms underlying this ability contribute to these difficulties. In the current experiment we examine spatial transformations in adults with ASD and typical adults. Participants performed egocentric transformations and mental rotation of bodies and cars. Results indicated that participants with ASD had general perceptual differences impacting on response times across tasks. However, they also showed more specific differences in the egocentric task suggesting particular difficulty with using the self as a reference frame. These findings suggest that impaired perspective taking could be grounded in difficulty with the spatial transformation used to imagine the self in someone else's place. © 2014 Springer Science+Business Media New York

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“…Umansky et al (2003) found a left-hand preference of 33% in a group of 145 patients with Rett syndrome. Cornish and McManus (1996) assessed young (3-5 years) and older (11-13 years) children with autism (N=35), 26 children with learning disabilities, and 89 typically developing (TD) children. Hand preference was measured three times using a set of 10 symmetrically presented unimanual preference tasks (e.g.…”

Section: Introductionmentioning

confidence: 99%

Laterality in Persons with Intellectual Disability. I—Do Patients with Trisomy 21 and Williams–Beuren Syndrome Differ from Typically Developing Persons?

et al. 2006

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Persons with trisomy 21 (T21) and Williams-Beuren syndrome (WBS) have different brain abnormalities which may affect manual laterality. We assessed 45 persons with T21 and 34 with WBS (mean age 13) and 81 typically developing children (TD). Manual laterality was assessed with a fifteen-item task administered two times, and Bishop's card-reaching task. We found more left-handers in the T21 group compared to the other two groups. Inconsistent laterality was higher in the two groups with genetic diseases than in the TD group. For Bishop's test, both T21 and WBS participants were less right-oriented than the TD group. They displayed different response patterns in midline crossing when reaching for the cards, but did not display more midline crossing inhibition than the TD group. Is atypical handedness linked to specific genetic syndromes and, more specifically for persons with T21, to the trisomy of some of the genes?

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Hand preference and hand skill in children with autism

Abstract: Hand preference and hand skill was assessed in two broad

Cited by 87 publications

References 15 publications

Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders

Neural bases for impaired social cognition in schizophrenia and autism spectrum disorders

Spatial Transformations of Bodies and Objects in Adults with Autism Spectrum Disorder

Laterality in Persons with Intellectual Disability. I—Do Patients with Trisomy 21 and Williams–Beuren Syndrome Differ from Typically Developing Persons?

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