Hand-ground fullerene-nanodiamond composite for photosensitized water treatment and photodynamic cancer therapy

Lee, Hongshin; Lee, Jung Seok; Moor, Kyle J.; Kim, Wook; Kim, Sang-Ryoung; Gim, Geondu; Lee, Jaesang; Kim, Hak Hyeon; Fahmy, Tarek M.; Kim, Jae Hong; Lee, Chang Ha

doi:10.1016/j.jcis.2020.12.020

Cited by 14 publications

(6 citation statements)

References 49 publications

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“…These water-soluble complexes C 60 -C 70 have high photoinduced cytotoxicity to HeLa, HaCaT, and RAW 264.7 cells under 350–500 nm light and no cytotoxicity (light >600 nm). 133 Moreover, to improve the hydrophilicity of C 60 , Lee et al 134 prepared a composite of C 60 powder and nanodiamond by simple grinding, which is a stable aqueous colloidal suspension. A part of the diamond shell carbon is oxygenated for hydrophilic property so that the complex is scattered in water and physiological media.…”

Section: Three-dimensional (3d) Scp Smentioning

confidence: 99%

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Sun¹,

Xue²,

Zhang³

2022

IJN

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Photodynamic therapy (PDT) is a noninvasive therapy for cancer and bacterial infection. Metal-free semiconducting conjugated polymers (SCP S ) with good stability and optical and electrical properties are promising photosensitizers (PSs) for PDT compared with traditional small-molecule PSs. This review analyzes the latest progress of strategies to improve PDT effect of linear, planar, and three-dimensional SCP S , including improving solubility, adjusting conjugated structure, enhancing PS-doped SCPs, and combining therapies. Moreover, the current issues, such as hypoxia, low penetration, targeting and biosafety of SCP S, and corresponding strategies, are discussed. Furthermore, the challenges and potential opportunities on further improvement of PDT for SCPs are presented.

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Section: Three-dimensional (3d) Scp Smentioning

confidence: 99%

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Sun¹,

Xue²,

Zhang³

2022

IJN

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“…Some recent studies have shown that the rational modification of fullerene nanoparticles can definitely enhance the effect of photodynamic therapy. Fullerene-nanodiamond composite is internalized by cancer cells and induced cell apoptosis without noticeable toxicity [ 92 ]. NIR light-harvesting fullerene-based nanoparticles (DAF NPs) can effectively inhibit tumor growth through synergetic photodynamic and photothermal therapies, which provides a new sight of photosensitizer design for enhanced cancer phototheranostics [ 93 ].…”

Section: Fullerene Derivatives: Promising New Anti-tumor Nanoparticlesmentioning

confidence: 99%

Antitumor Activity and Potential Mechanism of Novel Fullerene Derivative Nanoparticles

Kollie

Liu

et al. 2021

Molecules

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The development of novel nanoparticles as a new generation therapeutic drug platform is an active field of chemistry and cancer research. In recent years, fullerene nanoparticles have received extensive attention due to their unique physical and chemical properties. Properly modified fullerene nanoparticles have excellent biocompatibility and significant anti-tumor activity, which makes them have broad application prospects in the field of cancer therapy. Therefore, understanding the anti-tumor mechanism of fullerene nanoparticles is of great significance for the design and development of anti-tumor drugs with low toxicity and high targeting. This review has focused on various anti-tumor mechanisms of fullerene derivatives and discusses their toxicity and their distribution in organisms. Finally, the review points out some urgent problems that need solution before fullerene derivatives as a new generation of anti-tumor nano-drug platform enter clinical research.

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“…Allotropes of carbon have great diversity in size and shape. Based on the morphology, carbon nanoallotropes are categorized into two classes, including nanostructures with inner cavities (carbon nanotubes (CNTs) [21] and fullerenes [22]) and not bearing inner voids (graphene [23], carbon dots (CDs) [24], and carbon nano onions (CNOs)). In addition to graphene nanoribbons [25], graphene oxides [26], and nanodiamonds [27], some macro and micro-structures are formed by carbon materials, for instance, 3-dimensional (D) microspheres, 2D films, and 1D nanowires.…”

Section: Carbon Allotropes-based Drug Delivery Carriers For Cancer Therapymentioning

confidence: 99%

“…Moreover, the photodynamic tumor therapy studies showed that ND-C60 without apparent toxicity could be internalized by tumor cells and made cell apoptosis. Besides, the treat- ment of ND-C60 with mice cells bearing tumors along with light irradiation extended survival time by reducing cancer [22].…”

Section: Nanodiamondsmentioning

confidence: 99%

“…The mechanisms of varied behaviors related to the many fullerene derivatives have still been unidentified in alive cells. The reactive oxygen species (ROS) generated along with the light-absorbing potential of fullerene (C60) was extensively investigated for cancer therapy and the water treatment of photosensitizer [22]. Fullerene displays superb capability to tumor therapy.…”

Section: Fullerenementioning

confidence: 99%

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Application of carbon allotropes composites for targeted cancer therapy drugs: A review

Niazvand¹,

Wagh

Khazraei

et al. 2021

jcc

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In recent years, various drug carrier nanomaterials have been investigated to improve drug delivery systems in cancer treatment. However, an ongoing requirement exists for more beneficial therapeutic materials, yielding rapid clearance, high capacity for reducing systemic toxicity via specific-tumor targeting, and superior drug solubility. Given that, carbon allotropes, including Active Carbon (AC), carbon nanotubes (CNTs), graphene and graphene oxides (GOs), nanodiamonds (NDs), fullerenes, carbon nanohorns, soporous carbons, and carbon dots, have been studied owing to their high thermal conductivity, rigid structure, flexibility for modification and functionalization, adequate surface-to-volume ratio, and high biocompatibility. This review aims to overview recent advances in applying different carbon allotrope composites in drug delivery-based cancer therapy systems.

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Hand-ground fullerene-nanodiamond composite for photosensitized water treatment and photodynamic cancer therapy

Cited by 14 publications

References 49 publications

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Antitumor Activity and Potential Mechanism of Novel Fullerene Derivative Nanoparticles

Application of carbon allotropes composites for targeted cancer therapy drugs: A review

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