Hand eczema severity and quality of life: a cross‐sectional, multicentre study of hand eczema patients

Agner, Tove; Andersen, Klaus Ejner; Brandão, Francisco Menezes; Bruynzeel, Derk P.; Bruze, M.; Frosch, Peter J.; Gonçalo, Margarida; Goossens, An; Coz, Christophe J. Le; Rustemeyer, Thomas; White, Ian R.; Diepgen, Thomas L.

doi:10.1111/j.1600-0536.2008.01362.x

Cited by 196 publications

(234 citation statements)

References 17 publications

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“…1,12,20,21 Kavli et al asked to 14.667 person if they had an allergic hand eczema during the previous 12 months and found out 4.9% of men and 13.2% of women had had allergic eczema. Women under 35 years old were having 3 times more common hand eczema than men.…”

Section: Resultsmentioning

confidence: 99%

“…HD may have negative effects on both communication with other people and sexual contact so all of them make patient embarrassed in his social and business life with many restrictions. 1,2 While visible character and effects on functionality of HD are apparent, foot dermatoses (FD) which are covered by socks and shoes most of the time and can not be seen by others, are not considered to be as a real disease by some patients. Beside these, if a patient does not tell the physician about the problem of his feet, the physician may forget to examine the feet in routine dermatological examination.…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of Two Proximal Femoral Nail Devices For Fixation of Unstable Intertrochanteric Femur Fractures

Herman¹,

Landau²,

Tenenbaum³

et al. 2011

IJOS

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Aims: We aimed to sort out clinical types, localizations and frequencies of only hand dermatoses (HD), only foot dermatoses (FD) and both hand and foot dermatoses (HFD) and to evaluate the relationship with sociodemographic parameters. Methods and Material: Dermatological examination of 450 outpatients was done and the relationship between the frequencies of diseases, localizations of the lesions and sociodemographic features was assessed statistically. Results: The frequencies of dermatoses were 34% for tinea pedis, 29% for eczema, 9% for warts, 5% for corns, 3% for psoriasis and 21% for the others in the participiants. Tinea pedis was the most frequent dermatose of men while eczema of women. HD except warts were the most frequent in housewives while warts in students. The most frequent HFD were psoriasis, eczema and tinea.Statistical analysis used: Chi square test, one way ANOVA test and tukey's test were used for statistical assessments Results: The frequencies of dermatoses were 34% for tinea pedis, 29% for eczema, 9% for warts, 5% for corns, 3% for psoriasis and 21% for the others in the participants. Tinea pedis was the most frequent dermatose of men while eczema of women. HD except warts were the most frequent in housewives while warts in students. The most frequent HFD were psoriasis, eczema and tinea.Conclusions: We believe that elucidating the frequencies, clinical localizations and demographic features of these dermatoses will be helpful both for diagnosing and decreasing the incidence of these diseases in general population which seem to be a common health problem.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Comparison of Two Proximal Femoral Nail Devices For Fixation of Unstable Intertrochanteric Femur Fractures

Herman¹,

Landau²,

Tenenbaum³

et al. 2011

IJOS

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“…El eccema de manos es una enfermedad episódi-ca y crónica con un impacto negativo sobre la calidad de vida de los pacientes afectados 4,5 , comparable a los pacientes con dermatitis atópica y psoriasis 6 . Es una entidad frecuente que se presenta con síntomas clínicos variados, desde cuadros muy leves hasta tan severos que pueden llevar a la baja laboral, cambio de ocupación o discapacidad permanente.…”

Section: Aspectos Psicosociolaboralesunclassified

“…Asimismo, no se encontraron diferencias significativas en el impacto sobre la calidad de vida entre mujeres y hombres, a pesar de la mayor afectación clínica de estos últimos 5 .…”

Section: Aspectos Psicosociolaboralesunclassified

Tratamiento del eccema de manos

Hernando¹,

Baldrich²

2012

Más Dermatol.

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“…Severe CHE carries a debilitating social stigma which is associated with an impaired quality of life, comparable to that seen in patients with generalised eczema and psoriasis. 4 In addition, hand eczema has been shown to be a major cause of prolonged sick leave and has been reported to lead to job loss. 5 Patients with CHE have a poor prognosis; it is a self-perpetuating condition with a long-lasting and chronically relapsing course.…”

Section: Description Of the Underlying Health Problemmentioning

confidence: 99%

Alitretinoin for the treatment of severe chronic hand eczema

Paulden

Rodgers

Griffin

et al. 2010

Health Technol Assess

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This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of alitretinoin for the treatment of adults with severe chronic hand eczema refractory to topical steroid treatment in accordance with the licensed indication, based upon the evidence submission from Basilea Pharmaceuticals Ltd to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal process. The clinical evidence came from a single placebocontrolled randomised controlled trial of daily treatment with alitretinoin for 12-24 weeks, with follow-up for a further 24 weeks, in patients with severe chronic hand eczema (CHE) unresponsive to topical steroids. A statistically significantly greater proportion of patients using alitretinoin achieved the primary end point of clear or almost clear hands by week 24 than did those with placebo. Dose-dependent headache was the most commonly reported adverse event in patients treated with alitretinoin. Serious adverse events were rare, but alitretinoin was associated with increases in both total cholesterol and triglycerides, which has implications for risks of future cardiovascular events. The manufacturer submitted a de novo decision analytic model to estimate, over a time horizon of 3 years, the cost-effectiveness of alitretinoin versus the other relevant comparators identified by NICE. In response to the points of clarification put to it by the ERG regarding the initial submission, the manufacturer provided additional evidence and a revised decision analytic model with a 'placebo' arm. In the manufacturer's original DOI: 10.3310/hta14suppl1/06Alitretinoin for the treatment of severe chronic hand eczema 40 submission to NICE, the base-case incremental cost-effectiveness ratios (ICERs) reported for alitretinoin were £8614 per quality-adjusted lifeyear (QALY) versus ciclosporin, -£469 per QALY versus psoralen + UVA (with alitretinoin dominant) and £10,612 per QALY versus azathioprine. These ICERs decreased as the time horizon was extended in sensitivity analyses. In patients with hyperkeratotic CHE and in women of child-bearing potential, the ICER remained below £20,000. When the health-related quality of life (HRQoL) values used in the model were replaced with those derived from an alternative study, these ICERs increased significantly (to £22,312 per QALY for alitretinoin versus azathioprine). In the revised model, alitretinoin was reported to have an ICER of £12,931 per QALY gained versus supportive care (placebo). However, the model underestimates the costs of treatment associated with alitretinoin.

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Hand eczema severity and quality of life: a cross‐sectional, multicentre study of hand eczema patients

Abstract: Background and Objectives: Hand eczema is a chronic disease with negative impact on quality of life (QoL). In this study, QoL in hand eczema patients is assessed and related to age, sex, severity, and diagnostic subgroups.

Cited by 196 publications

References 17 publications

A Comparison of Two Proximal Femoral Nail Devices For Fixation of Unstable Intertrochanteric Femur Fractures

A Comparison of Two Proximal Femoral Nail Devices For Fixation of Unstable Intertrochanteric Femur Fractures

Tratamiento del eccema de manos

Alitretinoin for the treatment of severe chronic hand eczema

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