Hancornia speciosa serum latex fraction: a non-allergenic biomaterial

Costa, Amanda Fernandes; Gonçalves, Kerolayne; Bailão, Elisa Flávia Luiz Cardoso; Caramori, Samantha Salomão; Valadares, Marize Campos; Gonçalves, Pablo José; Almeida, Luciane Madureira

doi:10.1590/1519-6984.251075

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Besides the use in traditional medicine, the literature shows the high angiogenic (Almeida et al 2014;D'Abadia et al 2020;Bonete et al 2020), osteogenic (Floriano et al 2016;dos Santos Neves et al 2016), antioxidant (D'Abadia et al 2020), and anti-inflammatory (Marinho et al 2011) potential of the H. speciosa latex. Regarding the toxic potential, the H. speciosa latex does not show cytogenotoxic effects against human cells (Costa et al 2023), animals (Almeida et al 2014), and plants (Ribeiro et al 2016).…”

Section: The Role Of Enzymes In the Angiogenic Activity Ofmentioning

confidence: 96%

The role of enzymes in the angiogenic activity of Hancornia speciosa latex

et al. 2022

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The Hancornia speciosa latex has shown angiogenic activity. Angiogenesis plays a major role in wound healing, and materials that stimulate this process could be used to develop drugs. This study aimed to explain the role of proteins in the H. speciosa serum fraction latex in angiogenesis. Hence, this material was treated with proteinase K and the proteins were inactivated. After protein inactivation, angiogenic activity was assessed with the chick chorioallantoic membrane assay. The result showed that the proteins in the serum fraction are responsible for angiogenic activity. Then, the total protein content in the serum fraction and its enzymatic activity were investigated. The low protein content observed in the H. speciosa serum fraction latex suggests that this biomaterial could be used to develop new drugs with a hypoallergenic response. Despite the low protein content, there was a significant enzymatic activity of at least three enzymes in the serum fraction latex: β-1,3 glucanase, β-glucosidase, and proteases. These enzymes seem to influence the healing process, assisting debridement, extracellular matrix remodeling, and collagen deposition, and decreasing the chances of contamination by microorganisms. In conclusion, the enzymes in the H. speciosa serum latex are associated with the angiogenic activity of this biomaterial and may be used to assist the wound healing process.

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Section: The Role Of Enzymes In the Angiogenic Activity Ofmentioning

confidence: 96%

The role of enzymes in the angiogenic activity of Hancornia speciosa latex

et al. 2022

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“…Latex from this species, popularly known as mangabeira , is used as herbal medicine for treatment of dermatoses, tuberculosis, gastric ulcers, fractures, and fungal diseases 17 - 19 . Literature data report that this natural compound is biocompatible, non toxic 20 , 21 and has marked angiogenic properties 22 , 23 , as well as osteogenic 24 , anti-inflammatory 25 , antioxidant, 23 and antifungal 26 . These properties suggest that H. speciosa latex could be explored as source of new phytomedicines for wound treatment.…”

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confidence: 99%

Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation

D’Abadia

Lemes²,

Reis

et al. 2022

Acta Cir. Bras.

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Purpose: Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats’ wounds. Methods: One hundred and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen. Results: The therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues. Conclusions: H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.

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