Hancornia speciosa Gomes induces hypotensive effect through inhibition of ACE and increase on NO

Abstract

The present work demonstrated that Hancornia speciosa has a potent hypotensive effect in normotensive mice. The inhibition of ACE leading to reduction on angiotensin II and increase on NO levels might account for the hypotensive effect. These results support the use of Hancornia speciosa by traditional medicine as antihypertensive.

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

“…In the case of H. speciosa, some scientific studies have showed the pharmacological potential of different parts of this plant. The extract obtained from the leaves has a hypotensive effect (Ferreira et al, 2007;Silva et al, 2011), the bark has anti-bactericidal activity (Moraes et al, 2008), and the latex has anti-inflammatory (Marinho et al, 2011) and angiogenic activities (Almeida et al, 2014). All these studies have been important to validating popular use of the mangabeira in diverse health practices.…”

Intraspecific differentiation of Hancornia speciosa revealed by simple sequence repeat and random amplified polymorphic DNA markers

“…To date, there have been very few studies of genetic diversity in mangabeira populations, and all of them use RAPD markers as the molecular tool (Moura et al, 2005(Moura et al, , 2011Costa et al, 2011;Silva et al, 2011) due to the absence of the species genome information. As noted, only six sequences of H. speciosa appear in the GenBank database.…”

“…The primer sequences were developed by Mishra et al (2011). For RAPD experiments, we tested four oligonucleotide primers that were previously used by Silva et al (2011) in mangabeira and six oligonucleotide primers used by Lal et al (2011) (Table 1). …”

“…Although the fruits are considered the main commercial product, other products from mangabeira have commercial value or at least potential. For example, the extract obtained from the leaves can have a hypotensive effect (Ferreira et al, 2007a,b;Silva et al, 2011). Different flavonoids, catechins, anthocyanins, and tannins extracted from the bark may be used to treat the gastritis caused by Helicobacter pylori (Moraes et al, 2008) or to stimulate liver functions and help treat diabetes, hypertension, and dermatitis (Ritter et al, 2002;Macedo and Ferreira, 2004).…”

Coletânea bibliográfica acadêmica sobre a mangabeira (Hancornia speciosa Gomes)

“…A maioria (7) das pesquisas utilizou extrato de folhas de mangabeira para investigar as propriedades medicinais da espécie, o que, de certa forma, é preferível ao uso de outras partes da planta como as raízes ou casca -que podem causar danos mais significativos ao espécime vegetal quando extraídos; foi estudado, nos extratos de folhas: a atividade anti-hipertensiva (Endringer 2007), efeito hipotensor (Silva et al 2011c) e vasodilatador (Ferreira et al 2007a;Ferreira et al 2007b;Campana 2009), efeito quimiopreventivo (Endringer et al 2009) e desenvolveram um método para quantificar bornesitol, um constituinte bioativo que atua também na atividade anti-hipertensiva (Pereira et al 2012). …”