Hancornia speciosa Gomes (Apocynaceae) as a potential anti-diabetic drug

Pereira, Aline Carvalho; Pereira, Ana Bárbara Dias; Moreira, Carolina Campos Lima; Botion, Leida Maria; Lemos, Virgı́nia S.; Braga, Fernão Castro; Côrtes, Steyner F.

doi:10.1016/j.jep.2014.11.050

Cited by 61 publications

(61 citation statements)

References 25 publications

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“…This biome has a wide variety of medicinal plants used in folk medicine. Many of these plants have been investigated, and their antioxidant [2], antimicrobial [3], antidiabetic [4], anti-inflammatory [5], and cytotoxic [6] activities, among others, have been scientifically proven.…”

Section: Introductionmentioning

confidence: 99%

“…In this species, the roots have antihypertensive and wound-healing activities [7]; the bark has antidiabetic, anti-obesity, antimicrobial, and gastroprotective activities [3,8,9]; the latex has anti-inflammatory activity [10]; and the leaves have antihypertensive [11], vasodilator [12,13], anti-inflammatory [14,15], and antidiabetic [4] activities and are used for treatment of dysmenorrhea [16]. …”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

et al. 2016

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Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death. The chemical compounds were identified by liquid chromatography coupled to mass spectrometry (LC-MS/MS). The antioxidant activity of the EEHS was investigated using the method that involves the scavenging of 2,2-diphenyl-1-picrylhydrazyl free radicals as well as the inhibition of oxidative hemolysis and lipid peroxidation induced by 2,2’-azobis (2-amidinopropane) in human erythrocytes. The antimicrobial activity was determined by calculating the minimum inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration, and zone of inhibition. Kasumi-1 leukemic cells were used to assess the cytotoxic activity and mechanisms involved in cell death promoted by the EEHS. The chemical compounds identified were quinic acid, chlorogenic acid, catechin, rutin, isoquercitrin, kaempferol-rutinoside, and catechin-pentoside. The EEHS demonstrated antioxidant activity via the sequestration of free radicals, inhibition of hemolysis, and inhibition of lipid peroxidation in human erythrocytes incubated with an oxidizing agent. The antimicrobial activity was observed against American Type Culture Collection (ATCC) and hospital strains of bacteria and fungi, filamentous fungi and dermatophytes. The cytotoxic activity of the EEHS was induced by apoptosis, reduction of the mitochondrial membrane potential, and activation of cathepsins. Together, these results indicate the presence of phenolic compounds and flavonoids in the EEHS and that their antioxidant, antimicrobial, and cytotoxic activities in acute myeloid leukemia cells are mediated by apoptosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

et al. 2016

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“…The deficiencies on the knowledge on this species appear to have minimized with the increasing number of scientific articles published in recent years. This increase may be the result of the disclosure of results on the economic potential of this species, both in the area of production and fruit conservation (CAMPOS et al, 2011;CONAB, 2014) as in the area of use of compounds in pharmacology (SILVA et al 2011;MARINO et al, 2011;ALMEIDA et al, 2014;PEREIRA et al, 2015). Increased knowledge about the economic potential of this species will help disclosing its economic importance, thus contributing to increase its cultivation and conservation (CALIMAN et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

“…In addition to fruits, other important by-products with pharmacological potential can be extracted from this plant. For example, studies have shown that H. speciosa leaves have bioactive compounds that effectively control blood pressure (SILVA et al 2011) and diabetes (PEREIRA et al, 2015. ); and the latex of this species has anti-inflammatory (MARINO et al, 2011), angiogenesis action (ALMEIDA et al, 2014) and osteogenic action (FLORIANO et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

STATE OF THE ART OF SCIENTIFIC LITERATURE ON Hancornia speciosa: TRENDS AND GAPS

et al. 2016

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ABSTRACT-The economic and scientific interest in Hancornia speciosa (mangabeira) has been growing in recent years, mainly due to the marketing of fruit and extraction of natural compounds with high pharmacological potential. In this study, a scientometric survey about mangabeira was carried out in order to promote and direct future studies on the species. As a result, low scientific productivity associated with this species was found, with only 131 articles published in the last 69 years. In addition, this study identified some trends in bibliographic production on mangabeira, among them: the increasing number of articles over the years; scientific dissemination in nationwide journals; the main focus of this study is associated with agronomic studies; the experimental approach is more frequent and usually associated with populations of restricted geographical distribution; and the scientific production is mainly from education institutions. Furthermore, this study also allowed the identification of some gaps in knowledge about mangabeira, among them the difficulty in describing and characterizing botanical lines; lack of analysis of the genetic diversity of widely distributed populations; lack of management and conservation projects for the species; lack of description of cultivation, collection and preservation techniques of fruits; and lack of identification of natural compounds responsible for its pharmacological activity. It is expected that the data generated in this study will serve to direct future studies on H. speciosa. Index terms: mangabeira, native fruit, scientometrics. ESTADO DA ARTE DA LITERATURA CIENTÍFICA SOBREHancornia speciosa: TENDÊNCIAS E LACUNAS RESUMO-O interesse econômico e científico sobre Hancornia speciosa (mangabeira) vem crescendo nos últimos anos, devido principalmente à comercialização de seu fruto e extração de compostos naturais com alto potencial farmacológico. Neste estudo, foi realizado um levantamento cienciométrico sobre a mangabeira, com o objetivo de fomentar e direcionar futuras pesquisas sobre a espécie. Como resultado, verificou-se a baixa produtividade científica a respeito da espécie, com a publicação de apenas 131 artigos nos últimos 69 anos. Além disso, o presente estudo identificou algumas tendências na produção bibliográfica sobre a mangabeira, com destaque para: o aumento do número de artigos ao longo dos últimos anos; o fato de a divulgação científica ser realizada principalmente em revistas de âmbito nacional; a abordagem experimental ser mais frequente do que a abordagem teórico-descritiva; os trabalhos experimentais serem geralmente associados às populações de distribuição geográfica restrita; e a produção científica ser proveniente, principalmente, de Instituições de Ensino Superior. Por outro lado, este estudo também permitiu a identificação de algumas lacunas no conhecimento sobre a mangabeira, entre as quais se destacam: a dificuldade em descrever e caracterizar as linhagens botânicas; a falta de análise da diversidade genética de populações de ampla dist...

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“…Além de servir como alimento, as folhas H. speciosa possuem um elevado potencial farmacológico com efeito anti-hipertensivo e vasodilatador, são utilizadas para extração de substâncias ativas (esteroides, triterpenos e taninos), para controle da pressão arterial (PEREIRA et al, 2012) e diabetes (PEREIRA et al, 2015.). Já a casca é usada no tratamento de gastrite causada por Heliobacter pylori (MORAES et al, 2008).…”

Section: Introductionunclassified

FENOLOGIA DE Hancornia speciosa GOMES (APOCYNACEAE) EM MONTES CLAROS DE GOIÁS, BRASIL

Almeida¹,

Silva²,

Menino³

et al. 2018

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Hancornia speciosa Gomes (Apocynaceae) as a potential anti-diabetic drug

Abstract: Hancornia speciosa has a potential anti-diabetic effect through a mechanism dependent on inhibition of α-glucosidase and increase on glucose uptake. These results give support to the use on traditional medicine of this medicinal plant.

Cited by 61 publications

References 25 publications

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

STATE OF THE ART OF SCIENTIFIC LITERATURE ON Hancornia speciosa: TRENDS AND GAPS

FENOLOGIA DE Hancornia speciosa GOMES (APOCYNACEAE) EM MONTES CLAROS DE GOIÁS, BRASIL

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