Hamilton depression rating subscales to predict antidepressant treatment outcome in the early course of treatment

Helmreich, Isabella; Wagner, Stefanie; König, J.; Kohnen, Ralf; Szegedi, Armin; Hiemke, Christoph; Tadić, André

doi:10.1016/j.jad.2014.12.043

Cited by 9 publications

(11 citation statements)

References 83 publications

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“…Sensitivity reflects how much the scale is effective to identify correctly individuals who don't have depression (false-negative results), this way, the MADRS and HAMD 7 version are the most indicated rating scales to evaluate depressive individuals on this sample. Nonetheless, reliability results for short versions indicated that that scales has good sensitivity and specifity scores 23 and HAMD was not sensitive to specify depression symptoms as expected 12,13,17 . Addictionally, in contrast to the other subscales the McIntyre et al 8 subscale perform the best reliability and sensibility scores, and was the best version to predict results as HAMD 17, and showed the best correlation indices.…”

Section: Discussionmentioning

confidence: 91%

“…Helmreich et al 23 investigates the predictive ability for treatment outcome of HAMD-17 item and a HAMD core depressive symptoms version, which includes depressed mood, physic anxiety, low self-esteem, feeling of guilt and work and activities; other items as, suicide, agitation, retardation, somatic anxiety, general somatic symptoms and libido were included separately. The study was based on a severe 210 MDD outpatients evaluated at inclusion, baseline and after two weeks of antidepressant treatment and the improvement criteria was a reduction of equal to or more than 20% after baseline evaluation.…”

Section: Introductionmentioning

confidence: 99%

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Predicting response to treatment and discriminating bipolar and depression symptoms using Hamilton Depression Rating Scale

Carneiro

Cavalcanti

Carvalho

et al. 2017

J. bras. psiquiatr.

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Objective: The present study aims to compare the diagnostic ability of the HAMD 17 items with shorter versions of 7 and 6 items. Methods: A total of 133 patients from a 6 month clinical trial diagnosed with mood disorders (60.2% with Major Depressive Disorder and 39.8% with bipolar type I disorder) were recruited. Results: The 17 items HAMD scale showed similar results as compared with shorter versions. Furthermore, almost all patients' diagnosed with Major Depressive Disorder scored more compared to Bipolar Disorder, but the difference was not significant. Conclusion: This study allows that the use of a shorter version of HAMD might be an adequate possibility, and also that depressive symptoms were similar among groups. RESUMOObjetivo: O presente estudo tem por objetivo investigar a habilidade diagnóstica da HAMD 17 comparada a versões breves de 7 e 6 itens. Métodos: Foram selecionados 133 participantes recrutados de um ensaio clínico (60,2% com Depressão Maior e 39,8% com Transtorno Bipolar tipo I). Resultados: A versão de 17 itens da HAMD mostrou resultados similares quando comparada às versões breves. Ademais, quase todos os pacientes diagnosticados com Depressão Maior apresentaram maiores pontuações, contudo, essa diferença não foi estatisticamente significativa. Conclusão: Este estudo demonstra que o uso de uma versão breve da HAMD pode ser uma possibilidade adequada e que os sintomas depressivos se mostraram similares entre os grupos de bipolares e depressivos.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Predicting response to treatment and discriminating bipolar and depression symptoms using Hamilton Depression Rating Scale

Carneiro

Cavalcanti

Carvalho

et al. 2017

J. bras. psiquiatr.

View full text Add to dashboard Cite

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“…Nine are scored from 0-2. A HAM-D-17 score of 0-7 is considered normal, a score of 8-13 suggest mild depression, a score of 14-18 is related to a moderate depression, while a score of 19-22 has been associated with severe depression and a score above 22 is suggestive of a very severe depression [22]. Based on Mr.I, clinical presentation and psychiatric assessment his PPND met the criteria of a severe MDD requiring immediate and prompt treatment.…”

Section: Screening and Diagnostic Toolsmentioning

confidence: 99%

Vilazodone for the Treatment of Paternal Post Natal Depression

Khouzam¹

2017

Clin Depress

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Maternal postpartum depression is well recognized by clinicians as one of the psychiatric complication of delivery, conversely paternal postpartum depression or paternal postnatal depression which affects up to 10% -14% of new fathers 6 to 12 months after a child birth is rarely recognized and treated. Without proper diagnosis and prompt treatment paternal postnatal depression could lead to dire consequences including, deterioration in paternal mental health, loss of paternal bonding with the newborn child, which has been associated with long term later child psychiatric complications such as conduct disorders, hyperactivity, anxiety, depression, posttraumatic stress disorder and delays in language acquisition. It can also lead to marital conflicts, stressful family interactions and psychiatric disability leading to potential loss of income, and increase medical care costs. Like major depressive disorders the treatment of paternal postnatal depression may require psychopharmacological treatment typically with selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors. The purpose of this report is to increase clinicians awareness in recognizing and treating paternal postnatal depression as illustrated in a case of a 30 year-old new father who developed paternal postnatal depression and his progress in response to treatment with the first-of-class serotonin partial agonist reuptake inhibitor antidepressant vilazodone which basic pharmacology is summarized.

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“…A meta-analysis of eight fluoxetine studies with 1,658 patients showed that the Maier-Philip-6 and the Bech-6 subset scales were more sensitive to change than the full 17-item HAMD [ 13 ]. Use of the shorter HAMD subset scales also substantially reduces the time required for rating, about 15–20 min for the 17-item HAMD (HAMD-17) scale compared to 5 minutes for subset scales with 6–8 items [ 14 ]. Due to their good ability to detect changes in depressive symptoms and by focusing on core depressive symptoms [ 5 , 6 , 15 ], using briefer HAMD subset scales might be an economic and more precise measure of therapeutic outcomes in clinical trials and practice.✓…”

Section: Introductionmentioning

confidence: 99%

“…We did not include the Bech-6 as it does not incorporate the anxiety items ( Psychic and Somatic ) previously reported to predict treatment outcome [ 17 , 18 ]. The Evans-6 was reported to slightly outperform the Bech-6 in terms of predictive capacity in recent analyses [ 14 ] and therefore was included instead.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy

Fenton

McLoughlin

2021

PLoS ONE

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Objectives We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT. Methods This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three ‘full’ versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items. Results The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission. Conclusions Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.

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Hamilton depression rating subscales to predict antidepressant treatment outcome in the early course of treatment

Cited by 9 publications

References 83 publications

Predicting response to treatment and discriminating bipolar and depression symptoms using Hamilton Depression Rating Scale

Predicting response to treatment and discriminating bipolar and depression symptoms using Hamilton Depression Rating Scale

Vilazodone for the Treatment of Paternal Post Natal Depression

Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy

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