Hamartome folliculaire basaloïde : étude anatomoclinique

Hazemann, G.; Michel, Catherine; Mahé, A.; Lipsker, Dan; Cribier, B.

doi:10.1016/j.annder.2018.12.007

Cited by 4 publications

(6 citation statements)

References 44 publications

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“…Essa anormalidade promoveria uma função regulatória inadequada, com sinalização positiva constante, resultando em divisão e crescimento celular atípicos e descontrolados. [3][4][5] As manifestações clínicas são variadas, mas a maioria dos casos de HFB apresenta-se com uma ou múltiplas pápulas de 1 a 2mm de coloração normocrômica a acastanhada na face, couro cabeludo, pescoço, axila, tronco e região pubiana. 1,5 No caso descrito, as lesões eram discretamente hipopigmentadas, múltiplas e bilaterais.…”

Section: Discussionunclassified

“…Ela também pode estar associada à síndrome de Happle-Tinschert. 4 A despeito da variabilidade das manifestações do HFB, o aspecto histopatológico é notavelmente constante. Há cordões e extensões de células epiteliais basaloides ramificadas, dispostos verticalmente na derme superficial e média, a maioria em conexão com a epiderme e com os folículos pilosos, assim como no caso relatado.…”

Section: Discussionunclassified

“…O acometimento folicular é marcado pelo arranjo vertical que substitui o folículo normal, presença de lesão com periferia basofílica e Figura 1: Pápulas discretamente hipocrômicas no dorso nasal e nas regiões malares centro eosinofílico e estroma rico em mucina. 1,4 A imuno-histoquímica não é específica, mas pode auxiliar no diagnóstico. No estroma, há positividade para CD-34 e CD-10 (que também cora células matriciais).…”

Section: Discussionunclassified

“…2 Acredita-se que o crescimento rápido ou a alteração no aspecto clínico das lesões poderia alertar quanto ao desenvolvimento de CBC. [2][3][4] A exérese profilática não está recomendada, especialmente nas apresentações múltiplas. 4 Ainda não há algoritmo estabelecido para o tratamento do HFB.…”

Section: Discussionunclassified

“…[2][3][4] A exérese profilática não está recomendada, especialmente nas apresentações múltiplas. 4 Ainda não há algoritmo estabelecido para o tratamento do HFB. As opções descritas na literatura incluem excisão cirúrgica, crioterapia, laser de CO2, terapia fotodinâmica e imiquimode.…”

Section: Discussionunclassified

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Basaloid follicular hamartoma

Moura¹,

Nogueira²,

Lucas³

et al. 2022

S&CD

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Hamartoma folicular basaloideBasaloid follicular hamartoma RESUMO O hamartoma folicular basaloide (HFB) é um tumor anexial raro e benigno, que se assemelha ao carcinoma basocelular (CBC), e pode apresentar manifestações clínicas diversas. Uma mutação no gene PTCH, envolvido na síndrome de Gorlin-Goltz, poderia estar associada à patogênese dessa neoplasia. Descreve-se caso de menina, sete anos, apresentando múltiplas pápulas na face. Palavras-chave: Hamartoma; Carcinoma basocelular; Genes supressores de tumor.

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Section: Discussionunclassified

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Basaloid follicular hamartoma

Moura¹,

Nogueira²,

Lucas³

et al. 2022

S&CD

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Multidisciplinary approach to Gorlin-Goltz syndrome: from diagnosis to surgical treatment of jawbones

Spadari

Pulicari

Pellegrini

et al. 2022

Maxillofac Plast Reconstr Surg

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Background Gorlin syndrome, also known as Gorlin-Goltz syndrome (GGS) or basal cell nevus syndrome (BCNS) or nevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant familial cancer syndrome. It is characterized by the presence of numerous basal cell carcinomas (BCCs), along with skeletal, ophthalmic, and neurological abnormalities. It is essential to anticipate the diagnosis by identifying the pathology through the available diagnostic tests, clinical signs, and radiological manifestations, setting up an adequate treatment plan. Main body In the first part, we searched recent databases including MEDLINE (PubMed), Embase, and the Cochrane Library by analyzing the etiopathogenesis of the disease, identifying the genetic alterations underlying them. Subsequently, we defined what are, to date, the major and minor clinical diagnostic criteria, the possible genetic tests to be performed, and the pathologies with which to perform differential diagnosis. The radiological investigations were reviewed based on the most recent literature, and in the second part, we performed a review regarding the existing jawbone protocols, treating simple enucleation, enucleation with bone curettage in association or not with topical use of cytotoxic chemicals, and “en bloc” resection followed by possible bone reconstruction, marsupialization, decompression, and cryotherapy. Conclusion To promote the most efficient and accurate management of GGS, this article summarizes the clinical features of the disease, pathogenesis, diagnostic criteria, differential diagnosis, and surgical protocols. To arrive at an early diagnosis of the syndrome, it would be advisable to perform radiographic and clinical examinations from the young age of the patient. The management of the patient with GGS requires a multidisciplinary approach ensuring an adequate quality of life and effective treatment of symptoms.

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Localized basaloid follicular hamartoma: A case report

Ambooken

Asokan

Binesh

et al. 2020

JSSTD

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Basaloid follicular hamartoma (BFH) is a rare benign follicular tumor with varied clinical presentation. A 64-year-old male presented with a gradually enlarging plaque on the scalp of 10 years duration, the surface of which showed a unique cobblestone like appearance and dilated follicular openings discharging keratinous material. Histology was initially reported as trichofolliculoma. As the clinical picture was not suggestive of trichofolliculoma, the histopathology was reviewed. A final diagnosis of BFH was made based on the characteristic features such as distorted hair follicles with peripheral extensions of basaloid cells in a branching and anastomosing pattern. A periodic follow-up of such lesions is essential due to the risk of malignant transformation to basal cell carcinoma.

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Hamartome folliculaire basaloïde : étude anatomoclinique

Cited by 4 publications

References 44 publications

Basaloid follicular hamartoma

Basaloid follicular hamartoma

Multidisciplinary approach to Gorlin-Goltz syndrome: from diagnosis to surgical treatment of jawbones

Localized basaloid follicular hamartoma: A case report

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