Hamartomatous inverted polyps of the rectum

Abstract

Hamartomatous inverted polyps of the rectum are benign single slightly polypoid intramural masses of the bowel wall formed by an inverted or downward growth of mucosal glands through the muscularis mucosa into the submucosa. The atypical and distorted mucous glands and the ectopic position of both mucous glands and lakes of mucus in these benign lesions may cause an erroneous diagnosis of well‐differentiated carcinoma. Three cases with a differential diagnosis are presented.

Inverted Colonic Mucosal Lesion: Is This A New Entity of Colon Lesion?

“…6 Microscopically, ectopic distorted, slightly atypical mucous glands are present in a more or less circumscribed group in the submucosa, pushing the mucosa up to form a polypoid mass. Hamartomatous inverted polyps may simulate this microscopically, but are different from this present case in terms of their gross configuration and location.…”

“…5 This growth pattern may simulate a submucosal invading cancer. "Hamartomatous inverted polyps" also were reported as nonneoplastic lesion 6 ; these are protruded lesionsoccurring in the rectum-and formed by an inverted or downward growth of mucosal glands through the muscularis mucosa into the submucosa.…”

Solitary ulcer of the rectum

“…According to Haskell and Rovner (1965) the condition was first described by Cruveilhier (1829-42). Allen (1966), Epstein, Ascari, Ablow, Seaman, and Lattes (1966), and Wayte and Helwig (1967) have described what appears to be a similar or related pathology under the title 'Hamartomatous inverted polyps of the rectum' and 'Colitis cystica profunda'. The expression 'solitary ulcer' has been used at St Mark's Hospital since before World War II (Lloyd-Davies, 1969).…”

Localized colitis cystica profunda

“…Allen [6] in 1966 favored a h a m a r t o m atous pathogenesis. He described 3 patients with rectal lesions and concluded that the a n a t o m y of the lesions and its occurrence in y o u n g adults suggest that it is developmental in origin.…”