Halting the March: Primary Prevention of Atopic Dermatitis and Food Allergies

Bawany, Fatima; Beck, Lisa A.; Järvinen, Kirsi M.

doi:10.1016/j.jaip.2019.12.005

Cited by 34 publications

(36 citation statements)

References 210 publications

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“…Atopic dermatitis (AD) is an inflammatory eczematous skin disease with a chronic course. Generally, the onset is in childhood with a prevalence of 15-30%, although adult-onset AD is possible with a prevalence of 6-10% [68][69][70]. The inflammatory process at the basis of AD is recognized as an independent risk factor for bone resorption [68].…”

Section: Atopic Dermatitismentioning

confidence: 99%

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Osteoporosis in Skin Diseases

Sirufo

Pietro

Bassino

et al. 2020

IJMS

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Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice.

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Section: Atopic Dermatitismentioning

confidence: 99%

“…Low vitamin D levels can substantially reduce bone mass, which then leads to OP. Moreover, AD is also associated with obesity, cigarette smoking, and high alcohol consumption, all of which considered risk factors for OP [68]. Another important factor in the relationship between OP and AD is the therapy that patients with AD undergo.…”

Section: Atopic Dermatitismentioning

confidence: 99%

Osteoporosis in Skin Diseases

Sirufo

Pietro

Bassino

et al. 2020

IJMS

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“…Although this promising result, the utility of probiotics is still not well understood because efficacy is likely species-dependent, it may be host-dependent as well, and, most of all, the evidence on food sensitization and allergy is inconclusive. 10 In conclusion, it is almost clear the role of the microbiome in allergy, but the essential mechanism for proper immunological stimulation, in humans, has not been clarified yet. We hope that a better knowledge of microbiome function and how the environment may influence its development could lead to novel approaches to attempt to prevent allergic diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Protective effects were only seen with microbial mixtures or with single‐species interventions of L rhamnosus or L paracasei . Although this promising result, the utility of probiotics is still not well understood because efficacy is likely species‐dependent, it may be host‐dependent as well, and, most of all, the evidence on food sensitization and allergy is inconclusive 10 …”

mentioning

confidence: 99%

Human microbiome and allergy

Montecchiani

Fanos

2020

Pediatric Allergy Immunology

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Human microbiome contributes to critical functions that impact health and disease. It influences the development of the immune system, and the pathogenesis of immunological disorders included allergy. While it is easy to understand how airway microbiome, influencing local inflammation and immune activity, could contribute to shaping asthma phenotype, it is not so obvious to understand the influence by the gut microbiome, but there is growing evidence about it. The increase of allergic disorders in western countries led to investigate the role environment is playing and how it may change our microbiome and immune system, with the hope of finding new preventive approaches for allergy.

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“…The development of AM is driven by genetic predisposition, but environmental factors may play a key role in its clinical expression. Indeed, as shown by longitudinal studies, only a minority of children follow the classic pathway of AM (starting from AD and followed by sequential development of FA, asthma, and AR) (19,20). Earlier recognition of at-risk infants, regardless of CMA temporal appearance, allows fielding effective strategies to limit the occurrence of other atopic manifestations later in the life.…”

Section: Introductionmentioning

confidence: 99%

Dietary Prevention of Atopic March in Pediatric Subjects With Cow's Milk Allergy

et al. 2020

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Cow's milk allergy (CMA) is one of the most prevalent food allergies and the most expensive allergic diseases in the pediatric age. There is no cure for CMA, and actual disease management is based on strict avoidance of cow milk protein-containing foods, access to rescue medication, and use of substitutive formulas. Early-life CMA could be one of the first steps of the "allergic march" (AM), leading to the occurrence of other atopic manifestations later in the life, including asthma and oculorhinitis, with subsequent further increase of costs for health care systems and families of affected children. In the last years, diet is emerged as a relevant strategy to prevent allergic diseases through, at least in part, epigenetic modulation of immune system. We provide an overview of studies that investigate the potential role of different dietary strategies in preventing the AM in pediatric patients with CMA.

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Halting the March: Primary Prevention of Atopic Dermatitis and Food Allergies

Cited by 34 publications

References 210 publications

Osteoporosis in Skin Diseases

Osteoporosis in Skin Diseases

Human microbiome and allergy

Dietary Prevention of Atopic March in Pediatric Subjects With Cow's Milk Allergy

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