Halothane-Epinephrine-induced Cardiac Arrhythmias and the Role of Heart Rate

Zink, J; Sasyniuk, Betty I.; Dresel, Peter E.

doi:10.1097/00000542-197511000-00012

Cited by 48 publications

(13 citation statements)

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“…Thus, the Cl area is considered to be an important area for sympathovagal vasomotor control. On the other hand, it has been demonstrated that sympathetic blockade as well as vagal stimulation can attenuate the arrhythmogenic potency of adrenaline in the presence of halothane (Zink et al, 1975;Waxman et al, 1989;Kamibayashi et al, 1995). Therefore, the present study suggests that rilmenidine attenuates sympathetic neural activity or enhances vagal input at the C1 area via activation of imidazoline receptors and thus inhibits halothane-adrenaline-induced arrhythmia.…”

Section: Discussionmentioning

confidence: 56%

Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

Mammoto

Kamibayashi

Hayashi

et al. 1996

British J Pharmacology

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To elucidate the role of central imidazoline receptors in the genesis of adrenaline‐induced arrhythmias under halothane anaesthesia, we investigated the effects of rilmenidine, a selective agonist at imidazoline receptors, on this type of arrhythmia in dogs. Rilmenidine (1, 3, 10 μg kg−1, i.v.) did not affect basal haemodynamic parameters (heart rate and blood pressure), but dose‐dependently inhibited adrenaline‐induced arrhythmias under halothane anaesthesia. Although, rilmenidine has a weak affinity for α2‐adrenoceptors, pretreatment with idazoxan (10 μg kg−1, intracistenally i.c.), an imidazoline receptor antagonist which has also α2‐adrenoceptor blocking potency, blocked the antiarrhythmic effect of rilmenidine (10 μg kg−1, i.v.). In contrast, pretreatment with rauwolscine (20 μg kg−1, i.c.), a classical α2‐adrenoceptor antagonist with little affinity for imidazoline receptors, did not affect the effect of rilmenidine (10 μg kg−1, i.v.). Furthermore, bilateral vagotomy completely blocked the antiarrhythmic action of rilmenidine (10 μg kg−1, i.v.). It is suggested that the antiarrhythmic action of rilmenidine is due to the activation of central imidazoline receptors and that vagal tone is critical for this action of rilmenidine.

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Section: Discussionmentioning

confidence: 56%

Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

Mammoto

Kamibayashi

Hayashi

et al. 1996

British J Pharmacology

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“…The antiarrhythmic effect of halothane may be, at first sight, difficult to understand, in view of its ability to potentiate the arrhythmogenic actions of catecholamines (Zink, Sasyniuk & Dresel, 1975). However, the arrhythmogenic action of ischaemia is probably different, in both magnitude and aetiology, from catecholamine arrhythmogenesis.…”

Section: Experimental Design and Statistical Analysismentioning

confidence: 99%

Effects of prostaglandin E₂, propranolol and nitroglycerine with halothane, pethidine or pentobarbitone anaesthesia on arrhythmias and other responses to ligation of a coronary artery in rats

Collins

MacLeod

et al. 1983

British J Pharmacology

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1The effects of various cardiovascular drugs (prostaglandin E2 (PGE2), propranolol and nitroglycerine) and anaesthetic regimens (halothane, pethidine and pentobarbitone), upon the outcome of coronary artery ligation in acutely prepared rats were determined. 2 Effects upon arrhythmias, blood pressure, heart rate, mortality, ECG and the size of the occluded zone were determined for each drug in the presence of each anaesthetic. 3 PGE2 and nitroglycerine had no statistically significant effects on the outcome of ligation whatever the anaesthetic. Propranolol had limited antiarrhythmic actions. 4 The anaesthetic used had major effects upon the outcome of ligation, regardless of the cardiovascular drugs administered. 5 Pentobarbitone anaesthesia resulted in the highest mortality, and most arrhythmias. 6 Pethidine-N20 anaesthesia was associated with fewer arrhythmias. 7 Halothane-N20 anaesthesia markedly decreased the incidence and severity of arrhythmias, independent of the cardiovascular drug. 8 It was concluded that the anaesthetic used can have a major influence on ligation-induced arrhythmias in acutely prepared anaesthetized rats.

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“…An arrhythmia consisting of bigemini or trigemini was titrated using increasing doses of adrenaline. The mechanisms of this arrhythmia have been described by Riker et al (1955), Reynolds et al (1975) and Zink et al (1975. By increasing doses of adrenaline both the automaticity of the myocardial fibers and the pressor response increases and extrasystoles appear when a certain critical end systolic pressure for a particular animal is reached (Reynolds et al 1975).…”

Section: Discussionmentioning

confidence: 95%

Experimental Anti‐Arrhythmic Properties of Melperone, a Neuroleptic Butyrophenone

Petersen

1978

Acta Pharmacologica et Toxicologica

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The neuroleptic butyrophenone, melperone, has been compared with antiarrhythmics, neuroleptics, α‐blockers and β‐blockers in various experimental arrhythmias. Melperone 0.01–1 mg/kg intravenously antagonized ouabain‐induced arrhythmias in conscious rabbits to the same degree as propranolol 2 mg/kg and quinidine 10 mg/kg intravenously probably mainly via a CNS depressive effect. It was found to be considerably weaker than propranolol 2 mg/kg, when anaesthetized guinea pigs were used. Melperone 0.1–10 mg/kg was inactive against aconitine‐induced arrhythmias. Melperone 1–5 mg/kg antagonized adrenaline‐induced arrhythmias in halothane‐sensitized guinea pigs like phentolamine 1–5 mg/kg intravenously and was more potent than chlorpromazine, propranolol and quinidine. This study and an electrophysiological study suggest that melperone might be a type III anti‐arrhythmic drug, which at the same time depresses CNS and reduces afterload.

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Halothane-Epinephrine-induced Cardiac Arrhythmias and the Role of Heart Rate

Cited by 48 publications

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Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

Effects of prostaglandin E₂, propranolol and nitroglycerine with halothane, pethidine or pentobarbitone anaesthesia on arrhythmias and other responses to ligation of a coronary artery in rats

Experimental Anti‐Arrhythmic Properties of Melperone, a Neuroleptic Butyrophenone

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Halothane-Epinephrine-induced Cardiac Arrhythmias and the Role of Heart Rate

Cited by 48 publications

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Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

Antiarrhythmic action of rilmenidine on adrenaline‐induced arrhythmia via central imidazoline receptors in halothane‐anaesthetized dogs

Effects of prostaglandin E2, propranolol and nitroglycerine with halothane, pethidine or pentobarbitone anaesthesia on arrhythmias and other responses to ligation of a coronary artery in rats

Experimental Anti‐Arrhythmic Properties of Melperone, a Neuroleptic Butyrophenone

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Effects of prostaglandin E₂, propranolol and nitroglycerine with halothane, pethidine or pentobarbitone anaesthesia on arrhythmias and other responses to ligation of a coronary artery in rats