Halothane

Halothane binds in the adenine‐specific niche of crystalline adenylate kinase

“…The conditions used in vitro (2.5 mM halothane, 100"/~M AMP, pH 6.5 etc) can be assumed to be in the same range as the corresponding conditions in the muscle cells of an anaesthesized person [19]. Con, sequently our results support Schmidt's hypothesis on the aetiology of halothane-induced malignant hyperthermia [9,10].…”

“…It is indeed remarkable that all proteins for which specific interactions with halothane have been demonstrated [19] process functionally important binding sites for purine nucleotides; examples are microtubules [20], glutamate dehydrogenase [4], calcium-transport ATPases [5,21,22] and phosphoryl transferases [10,23]. This aspect could facilitate the search for the principal halothane receptors in normal anaesthesia.…”