Halophilic microorganisms: Interesting group of extremophiles with important applications in biotechnology and environment

Daoud, Lobna; Ali, Mamdouh Ben

doi:10.1016/b978-0-12-818322-9.00005-8

Cited by 15 publications

(10 citation statements)

References 50 publications

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“…The G+C content (40.14%) of YC#06 is different from Bϕ-B1251 (39.05%). Compared with microorganisms commonly found on earth (temperatures between 10°C and 40°C, near-neutral pH) ( 13 ), basic characteristics of YC#06 show that the phage has strong high temperature resistance and a relatively wide pH range, which shows thatYC#06 would facilitate the development of an alternative tool to control the spread of multidrug-resistant A. baumannii . Also, the candidates of phage for biocontrol or phage therapy should be obligately lytic to bacterium and should not have integrases, where the genome of phage integrates into host DNA and coexists in it; some antibiotic-resistant genes or other host fragments would be assembled into the new synthesis phages ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Synergism between Phage YC#06 and Antibiotics: a Combination Strategy to Target Multidrug-Resistant Acinetobacter baumannii In Vitro and In Vivo

et al. 2022

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The treatment of multidrug-resistant bacterial infection is an urgent clinical problem. The combination of bacteriophages and antibiotics could produce synergistic bactericidal effects, which could reduce the emergence of antibiotic resistance and antibiotic consumption in antibiotic-sensitive bacteria, restore efficacy to antibiotics in antibiotic-resistant bacteria, and prevent the occurrence of phage-resistant bacteria.

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Section: Discussionmentioning

confidence: 99%

Bactericidal Synergism between Phage YC#06 and Antibiotics: a Combination Strategy to Target Multidrug-Resistant Acinetobacter baumannii In Vitro and In Vivo

et al. 2022

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“…Similarly, halophilic (salt-loving) species have evolved proteins to be more acidic (negatively charged) to prevent aggregation in salty environments, and this salt tolerance is crucial to bioremediation strategies such as biofuel production (Daoud & Ben Ali, 2020). Since these thermophilic and halophilic adaptations occur at the individual protein level, they provide perfect test cases to study the effects of protein design.…”

Section: Protein Design Diminishes Extremophile Propertiesmentioning

confidence: 99%

Protein language models are biased by unequal sequence sampling across the tree of life

Ding,

Steinhardt

2024

Preprint

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Protein language models (pLMs) trained on large protein sequence databases have been used to understand disease and design novel proteins. In design tasks, the likelihood of a protein sequence under a pLM is often used as a proxy for protein fitness, so it is critical to understand what signals likelihoods capture. In this work we find that pLM likelihoods unintentionally encode a species bias: likelihoods of protein sequences from certain species are systematically higher, independent of the protein in question. We quantify this bias and show that it arises in large part because of unequal species representation in popular protein sequence databases. We further show that the bias can be detrimental for some protein design applications, such as enhancing thermostability. These results highlight the importance of understanding and curating pLM training data to mitigate biases and improve protein design capabilities in under-explored parts of sequence space.

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“…In addition to obtaining bacteriorhodopsin, halophilic microorganisms are interesting from a practical point of view for wastewater treatment [13,14] and the production of biodegradable plastics and emulsifiers [15]. The most promising direction of using BR at present is the development of materials for optical processing and data storage [1].…”

Section: The Object Of This Study Is the Processes Of Interaction Of ...mentioning

confidence: 99%

Design of chemically modified bacteriorhodopsin films for information protection systems

Трикур

Баторі-Тарці

Sichka

et al. 2022

EEJET

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The object of this study is the processes of interaction of fragments of purple membranes with certain chemicals, which affect the photochromic properties of bacteriorhodopsin films. This paper considers the possibility of modifying the properties of bacteriorhodopsin films by changing their chemical composition, which will make it possible to use such films to protect information. For this purpose, it has been determined which optical properties of bacteriorhodopsin are most important for its use in the field of information protection; films were made using various chemicals as impurities. It was shown that the introduction of impurities does not affect the absorption spectrum of bacteriorhodopsin, which indicates that it retains its properties. It has been established that impurity substances are evenly distributed in films. By studying the dynamics of photoinduced changes in films with different concentrations of chemical components, the effect of chemical modification on the photocycle of bacteriorhodopsin and the properties of film structures based on it was studied. Based on the results of experimental studies, it was found that by changing the chemical composition of films, it is possible to change the time of storage of the information recorded on them in the range from several to hundreds of seconds continuously. The sensitometric sensitivity of film structures also depends on the chemical composition and can vary in the range from 3.9·10–3 to 54·10–3 m2/J. At the same time, chemical modification is simpler from a technological point and cheaper from a financial point of view compared to other methods that make it possible to achieve similar results. The reported results suggest that chemically modified films based on bacteriorhodopsin have great potential for practical application in the field of information protection and access control

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Halophilic microorganisms: Interesting group of extremophiles with important applications in biotechnology and environment

Cited by 15 publications

References 50 publications

Bactericidal Synergism between Phage YC#06 and Antibiotics: a Combination Strategy to Target Multidrug-Resistant Acinetobacter baumannii In Vitro and In Vivo

Bactericidal Synergism between Phage YC#06 and Antibiotics: a Combination Strategy to Target Multidrug-Resistant Acinetobacter baumannii In Vitro and In Vivo

Protein language models are biased by unequal sequence sampling across the tree of life

Design of chemically modified bacteriorhodopsin films for information protection systems

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