Haloperidol plus promethazine for psychosis-induced aggression

Huf, Gisele; Alexander, Jacob; Allen, Michael; Raveendran, Nirmal S

doi:10.1002/14651858.cd005146

Cited by 39 publications

(72 citation statements)

References 31 publications

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“…Nonetheless, recent expert guidelines recommend newer atypical antipsychotics as first-line treatments in many cases, not only because atypical antipsychotics are more effective in many instances but also because they have fewer side effects (2). These guidelines recommend that if haloperidol is given, it should be administered with a benzodiazepine such as lorazepam or an anticholinergic such as Phenergan (Wyeth Pharmaceuticals Inc., Philadelphia, PA) to increase calming and decrease these side effects (3,4).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Safety of Olanzapine and Haloperidol in Combination with Benzodiazepines in Emergency Department Patients with Acute Agitation

Wilson

MacDonald

Vilke

et al. 2012

The Journal of Emergency Medicine

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Section: Introductionmentioning

confidence: 99%

A Comparison of the Safety of Olanzapine and Haloperidol in Combination with Benzodiazepines in Emergency Department Patients with Acute Agitation

Wilson

MacDonald

Vilke

et al. 2012

The Journal of Emergency Medicine

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“…It was the aim of the guideline development group (GDG) to promote pharmacological interventions which calmed rather than sedated the service user to enable psychosocial intervention. Haloperidol with promethazine is fast and effective at tranquillising or sedating the service user (Huf et al, 2004;. However, this combination has been tested outside the UK context.…”

Section: Discussionmentioning

confidence: 99%

“…Haloperidol with midazolam has been found to be effective and fast. However, midazolam is considered to have stronger respiratory effects than lorazepam (Huf et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…These studies have also been reviewed in a Cochrane review (Huf et al, 2004), which concluded midazolam has a faster onset than lorazepam, however both benzodiazepines have potential to cause respiratory depression. Therefore Huf et al (2004) favoured haloperidol with promethazine as the combination of choice for rapid tranquillisation. Outcome measure was tranquil or asleep.…”

Section: Thiothixene and Lorazepam Vs Haloperidol And Phenobarbitalmentioning

confidence: 99%

See 1 more Smart Citation

Establishing gold standard approaches to rapid tranquillisation: A review and discussion of the evidence on the safety and efficacy of medications currently used

Pratt

Chandler-Oatts

Nelstrop

et al. 2008

JPI

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Background: Rapid tranquillisation is used when control of agitation, aggression or excitement is required. Throughout the UK there is no consensus over the choice of drugs to be used as first line treatment. The NICE guideline on the management of violent behaviour involving psychiatric inpatients conducted a systematic examination of the literature relating to the effectiveness and safety of rapid tranquillisation (NICE, 2005). This paper presents the key findings from that review and key guideline recommendations generated, and discusses the implications for practice of more recent research and information. Aims: To examine the evidence on the efficacy and safety of medications used for rapid tranquillisation in inpatient psychiatric settings. Method: Systematic review of current guidelines and phase III randomised, controlled trials of medication used for rapid tranquillisation. Formal consensus methods were used to generate clinically relevant recommendations to support safe and effective prescribing of rapid tranquillisation in the development of a NICE guideline. Findings: There is a lack of high quality clinical trial evidence in the UK and therefore a 'gold standard' medication regime for rapid tranquillisation has not been established. Rapid tranquillisation and clinical practice: The NICE guideline produced 35 recommendations on rapid tranquillisation practice for the UK, with the primary aim of calming the service user to enable the use of psychosocial techniques. Conclusions and implications for clinical practice: Further UK specific research is urgently needed that provides the clinician with a hierarchy of options for the clinical practice of rapid tranquillisation.

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“…Um beurteilen zu können, ob vom Patienten eine erhöhte Fremdgefährdung ausgeht, muss unmittelbar nach Eintreffen am Einsatzort die Gefahrenlage eingeschätzt werden. Verbale Beleidigungen oder Drohungen, die nicht selten von manischen oder erregt-psychotischen [1,7,8]. Die Dosierung richtet sich in erster Linie nach der Symptomatik und der Reaktion auf vorherige Gaben.…”

Section: Introductionunclassified

Psychose und Manie

Messer

Pajonk

2016

Notfall Rettungsmed

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Haloperidol plus promethazine for psychosis-induced aggression

Cited by 39 publications

References 31 publications

A Comparison of the Safety of Olanzapine and Haloperidol in Combination with Benzodiazepines in Emergency Department Patients with Acute Agitation

A Comparison of the Safety of Olanzapine and Haloperidol in Combination with Benzodiazepines in Emergency Department Patients with Acute Agitation

Establishing gold standard approaches to rapid tranquillisation: A review and discussion of the evidence on the safety and efficacy of medications currently used

Psychose und Manie

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