Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans

Krum, Bárbara Nunes; Martins, Airton C.; Queirós, Libânia; Ferrer, Bertha Beatriz Socarrás; Milne, Ginger L.; Soares, Félix Alexandre Antunes; Fachinetto, Roselei; Aschner, Michael

doi:10.1007/s12035-020-02124-9

Cited by 7 publications

(3 citation statements)

References 72 publications

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“…Another investigation reported the repulsion due to 1-nonanol directly relates the dopamine level in C. elegans [20] so, introduction of BAK showed quick and stronger response indicating higher dopamine level in both wild type approximately to 42% and mutant strain NL5901 to 32%. Previous reports suggested that locomotary behavior is dependable on dopamine levels in worms [35], our investigation reveals both wild type and mutant strain NL5901 produced higher level of body movement and head thrash thus indicating positive effect of BAK on dopaminergic neurons thus help in reducing the aetiology of PD. To validate our ndings, qPCR analyses were conducted on lrk-1, the human ortholog being LRRK1 which encodes for synaptic vesicle transmission and plays a role in dopamine regulation.…”

Section: Discussionsupporting

confidence: 54%

Phenolic monoterpene Bakuchiol ameliorates age related Parkinsonism

Ranjan,

Khan,

Sharma

et al. 2024

Preprint

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The phenomenon of aging comes with various spontaneous physiological changes including structural, functional, molecular and cellular. whereas, deterioration from the normal physiology brings chronic changes associated with several neurodegenerative disorders. Neurodegenerative diseases related to aging are the most concerned topic due to their devitalizing conditions with lack of therapy options that simultaneously affects the economic and social status. In our study we illustrated the longevity and anti-parkinsonism activity of Bakuchiol (BAK), a phytomolecule from Psoralea corylifolia. Our result showed BAK elevate mean life span up to 38% along with the enhanced survival rate under stress. Additionally, BAK reduces ROS level via boosting anti-oxidant level through upregulating expression of anti- oxidative genes sod-3 and gst-4. Remarkably, BAK exhibits neuroprotective effects by attenuating α-synuclein levels. These findings suggest that, in addition to its antioxidant and lifespan-extending properties, BAK positively regulates neurological health. In summary, our study establishes the potential curative effects of BAK on age-related neurodegenerative disorders, positioning it as a promising nootropic drug in modern medicine with broader implications for age-related neurodegeneration.

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Section: Discussionsupporting

confidence: 54%

Phenolic monoterpene Bakuchiol ameliorates age related Parkinsonism

Ranjan,

Khan,

Sharma

et al. 2024

Preprint

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“…To understand the functional consequences of this morphological evaluation, we used a behavioral endpoint strongly dependent on DAergic signaling. We made use of the fact that worms, normally body-bending in their growth medium, move less dynamically, when they are exposed to feed ( de Bono and Maricq, 2005 ; Krum et al, 2021 ; Sawin et al, 2000 ). We assessed this “basal slowing response” (BSR) in nematodes exposed to food (bacteria) in the presence or absence of aerugine.…”

Section: Resultsmentioning

confidence: 99%

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Ückert,

Rütschlin,

Gutbier

et al. 2023

Environment International

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“…The opposite results have also been shown, i.e. changes in cholinergic and GABAergic signaling due to D2 antagonism (Krum et al, 2020). Furthermore, it was also shown that changes in DA may affect GABAergic egg release in the worms (Cermak et al, 2020).…”

Section: Discussionmentioning

confidence: 98%

Doxycycline inhibits α-synuclein-associated pathologiesin vitroandin vivo

Dominguez-Meijide

Parrales

Vasili³

et al. 2020

Preprint

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Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially proposed to be due to its anti-inflammatory properties. More recently, an additional mechanism by which doxycycline may exert its neuroprotective effects has been proposed as it has been shown that it inhibits amyloid aggregation. Here, we studied the effects of doxycycline on aSyn aggregation in vivo, in vitro and in a cell free system using real-time quaking induced conversion (RT-QuiC). Our results show that doxycycline decreases the number and size of aSyn aggregates in cells. In addition, doxycycline inhibits the aggregation and seeding of recombinant aSyn, and attenuates the production of mitochondrial-derived reactive oxygen species. Finally, we found doxycycline induces a cellular redistribution of the aggregates in an animal model of PD that is associated with a recovery of dopaminergic function. In summary, we provide strong evidence that doxycycline treatment may be an effective strategy against synucleinopathies.

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Haloperidol Interactions with the dop-3 Receptor in Caenorhabditis elegans

Cited by 7 publications

References 72 publications

Phenolic monoterpene Bakuchiol ameliorates age related Parkinsonism

Phenolic monoterpene Bakuchiol ameliorates age related Parkinsonism

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Doxycycline inhibits α-synuclein-associated pathologiesin vitroandin vivo

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