Haloperidol for delirium in critically ill patients – protocol for a systematic review

Barbateskovic, Marija; Kraus, Stefan; Collet, Marie Oxenbøll; Mathiesen, Ole; Jakobsen, Janus Christian; Perner, Anders; Wetterslev, Jørn

doi:10.1111/aas.13088

Cited by 7 publications

(14 citation statements)

References 61 publications

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“…85 86 The method has previously been applied by our group in systematic reviews with meta-analysis on a wide range of healthcare topics. [87][88][89][90][91][92][93][94] A PRISMA-P checklist file is attached (online supplementary additional file 1).…”

Section: Methods and Analysismentioning

confidence: 99%

Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis

et al. 2020

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IntroductionDiabetic foot ulcer represents a major health problem globally. Preliminary studies have indicated that systemic treatment of diabetic foot ulcer patients with hyperbaric oxygen therapy have beneficial effects on wound healing, risk of amputation, glycaemic control, atherosclerosis, inflammatory markers and other clinical and laboratory parameters. This protocol for a systematic review aims at identifying the beneficial and harmful effects of adding hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers.Methods and analysisThis protocol was performed following the recommendations of the Cochrane Collaboration and the eight-step assessment procedure suggested by Jakobsen and colleagues. We plan to include all relevant randomised clinical trials assessing the effects of hyperbaric oxygen therapy in the treatment of diabetic foot ulcer versus any control group with any intervention defined as standard wound care or similar, together with sham interventions. Our primary outcome will be: all-cause mortality, serious adverse events and quality of life. Our secondary outcomes will be: healing of index wound, major amputation and wound infection. Any eligible trial will be assessed and classified as either high risk of bias or low risk of bias, and our conclusions will be based on trials with low risk of bias. The analyses of the extracted data will be performed using Review Manager 5 and Trial Sequential Analysis. For both our primary and secondary outcomes, we will create a ‘Summary of Findings’ table and use GRADE (Grading of Recommendations Assessment, Development and Evaluation) assessment to assess the quality of the evidence.Ethics and disseminationWe use publicly accessible documents as evidence, there is no participant involvement at an individual level and an institutional ethics approval is not required. The results of the review will be sought published in a peer-reviewed journals, also in the event of insignificant results or null results, and thereby it will be disseminated to clinicians and public available.PROSPERO registration numberCRD42019139256.

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Section: Methods and Analysismentioning

confidence: 99%

Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis

et al. 2020

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“…This systematic review was conducted according to the pre-planned statistical analysis plan of the published protocol [19]. We registered the protocol in the international prospective register of systematic reviews database (PROSPERO) (CRD42017081133), used the methodology of the Cochrane Collaboration [20] and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) [17] (Electronic Supplementary Material (ESM)).…”

Section: Methodsmentioning

confidence: 99%

“…Two review authors (MB and SRK) independently extracted predefined data of the included trials using a predefined data collection form (ESM). The following data were collected: 1) Trial: country, duration of the trial, date of publication; 2 ) Participants: numbers randomised, numbers analysed, numbers lost to follow up/withdrawn, type of population, age, sex, disease severity, setting, delirium assessment, inclusion criteria, and exclusion criteria; 3) Interventions: intervention, comparator, duration and cointerventions; 4) Outcomes: predefined primary, secondary outcomes and timing of outcome measurement [19].…”

Section: Trial Selection and Data Extractionmentioning

confidence: 99%

“…We conducted a predefined sensitivity analysis by imputing missing outcome data in a best-worst case scenario and a worst-best case scenario to assess the potential impact of loss to follow-up [19,22].…”

Section: Dealing With Missing Datamentioning

confidence: 99%

“…We used the more conservative point estimate of the two, which is the point estimate closest to no effect. If the estimates from the two models were approximately equal, we used the estimate with the widest CI [19].…”

Section: Assessment Of Heterogeneitymentioning

confidence: 99%

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Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta‐analysis and Trial Sequential Analysis

Barbateskovic

Krauss²,

Collet

et al. 2019

Acta Anaesthesiol Scand

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Outcomes of critically ill children with pre‐existing mental health conditions

Krawiec,

Cash,

Ceneviva

et al. 2024

Pediatric Investigation

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ImportanceCritically ill children with pre‐existing mental health conditions may have an increased risk of poor health outcomes.ObjectiveWe aimed to evaluate if pre‐existing mental health conditions in critically ill pediatric patients would be associated with worse clinical outcomes, compared to children with no documented mental health conditions.MethodsThis retrospective observational cohort study utilized the TriNetX electronic health record database of critically ill subjects aged 12–18 years. Data were analyzed for demographics, pre‐existing conditions, diagnostic, medication, procedural codes, and mortality.ResultsFrom a dataset of 102 027 critically ill children, we analyzed 1999 subjects (284 [14.2%] with a pre‐existing mental health condition and 1715 [85.8%] with no pre‐existing mental health condition). Multivariable analysis demonstrated that death within one year was associated with the presence of pre‐existing mental health conditions (odds ratio 8.97 [3.48–23.15], P < 0.001), even after controlling for the presence of a complex chronic condition.InterpretationThe present study demonstrates that the presence of pre‐existing mental health conditions was associated with higher odds of death within 1 year after receiving critical care. However, the confidence interval was wide and hence, the findings are inconclusive. Future studies with a larger sample size may be necessary to evaluate the true long‐term impact of children with pre‐existing mental health conditions who require critical care services.

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Haloperidol for delirium in critically ill patients – protocol for a systematic review

Abstract: Our ambition with this systematic review is to provide reliable and powered evidence to better inform decision makers on the use of or future trials with haloperidol for the management of delirium in critically ill patients.

Cited by 7 publications

References 61 publications

Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis

Effects of adding adjunctive hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers: a protocol for a systematic review with meta-analysis and trial sequential analysis

Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta‐analysis and Trial Sequential Analysis

Outcomes of critically ill children with pre‐existing mental health conditions

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